Anxiety and depression in patients with chronic obstructive pulmonary disease and their relation to serum vitamin D levels

Year 2018, , 33 - 40, 26.02.2018

Derya Kocakaya Sehnaz Olgun Yıldızelı Ozan Kocakaya Huseyin Arıkan Emel Eryuksel Emel Eryuksel

https://doi.org/10.5472/marumj.398936

Cited By: 1

Abstract

Objectives: To determine whether serum vitamin D levels were

related to the prevalence of anxiety and depression among patients

with chronic obstructive pulmonary disease (COPD), as well as their

spirometry parameters, disease severity, and other clinical findings.

Materials and Methods: Ninety-two stable patients with

COPD aged over 18 years with no exacerbations in the previous

month were included. Symptom severity was assessed using the

modified Medical Research Council (mMRC) dyspnea scale and

COPD Assessment Test (CAT) scores. Spirometry tests were

performed and previous hospitalization histories were recorded

to determine ABCD groups of the patients according to their

combined COPD assessments. Their Body mass index, airflow

Obstruction, Dyspnea and Exercise capacity (BODE) indices were

calculated and the Hospital Anxiety and Depression Scale (HADS)

was administered. Serum vitamin D levels were determined using

immune electrochemiluminescence.

Results: According to the HADS scores, 16 patients (17.4%) had

the risk of anxiety and 29 (31.5%) had the risk of depression. The

risk of anxiety differed significantly (P= 0.016 Fischer’s exact test)

between the ABCD groups. Anxiety scores were positively correlated

with both mMRC (r= 0.315; P= 0.002) and CAT (r= 0.445; P= 0.000)

scores. Similarly, depression scores correlated positively with mMRC

(r= 0.249; P= 0.017) and CAT (r= 0.373; P= 0.000) scores. Neither

anxiety nor depression scores were significantly correlated with % of

predicted FEV1 (p= 0.339, P= 0.671). Serum vitamin D levels were

inversely correlated with anxiety (r= -0.215; P= 0.039) and depression

(r= -0.244; P= 0.019) scores. Anxiety scores were positively correlated

with BODE although not statistically significantly (r= 0.199; P= 0.058).

Conclusion: A negative correlation was revealed between

serum vitamin D levels and HADS scores, and symptom scores

were positively correlated to HADS scores, independent of % of

predicted FEV1.

Keywords

Anxiety, Depression, Vitamin D, Chronic obstructive pulmonary disease

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