Neoadjuvant tedavi sonrası küçük hücreli dışı akciğer kanseri olan hastaların cerrahi sonuçları

Year 2018, , 101 - 107, 31.10.2018

İlhan Ocakcıoglu Levent Alpay Nezih Onur Ermerak Hakan Kıral Cagatay Tezel Volkan Baysungur İrfan Yalcınkaya

https://doi.org/10.5472/marumj.474165

Abstract

Amaç: Neoadjuvan tedaviyi takiben küçük hücreli dışı akciğer

kanseri (KHDAK)’nin anatomik rezeksiyonu halen tartışmalı olsa

da, torasik cerrahi uygulamada yaygın kabul gören bir yaklaşımdır.

Bu çalışmanın amacı, neadjuvan tedaviyi takiben kurumumuzda

cerrahi operasyon uygulanan lokal ileri evre KHDAK’i, pancoast

tümörü ve soliter beyin metastazı olan akciğer kanseri hastalarının

klinik sonuçlarını, uzun dönem sağkalımını ve sağkalımı etkileyen

faktörleri kısaca değerlendirmektir.

Gereç ve Yöntem: Mart 2006 ve Mart 2012 tarihleri arasında

neoadjuvan tedaviyi takiben anatomik pulmoner rezeksiyon

uygulanan 70 KHDAK tanılı hasta çalışmaya alındı.

Bulgular: Üç yıllık sağkalım (% 39) ve 5 yıllık sağkalım (% 29)

sırasıyla 16±6,8 ve 37±9,89 ay idi. Ortalama sağ kalım 37,15±3,06 ay

olarak bulundu. Sağkalım oranı tümörün anatomik lokalizasyonuna

göre değerlendirildiğinde santral ve sol üst lob tümörlerinde daha

düşüktü (P=0,042). 5 yıllık ortalama sağkalım süreleri evre 0

hastalarda 50,00±5,65 ay, evre 1 hastalarda 35,39±5,85 ay, evre 2

hastalarda 37,40±6,89 ay ve evre 3 hastalarda 21,44±3,10 ay idi.

Sonuç: Neoadjuvan tedaviyi takiben anatomik pulmoner

rezeksiyon ile önemli sağkalım sonuçları elde edebiliriz.

Keywords

Küçük hücreli dışı akciğer kanseri, Neoadjuvan tedavi, Kemoterapi, Radyoterapi, Cerrahi

Surgical outcomes of patients with non-small cell lung cancer following neoadjuvant treatment

Abstract

Objective: Although, anatomical resection of non-small cell

lung cancer (NSCLC) following neoadjuvant therapy is still

controversial, it is a widely accepted approach for thoracic surgery

practice. The aim of this study is to briefly evaluate clinical results,

long term survival, and factors affecting survival of the patients

with locally advanced NSCLC, pancoast tumour and lung cancer

with solitary brain metastasis, who have been operated at our

institution following neoadjuvant therapy.

Materials and Method: Between March 2006 and March

2012, 70 patients with NSCLC diagnosis who underwent anatomic

pulmonary resection following neoadjuvant therapy were included

in the study.

Results: A three year survival (39%) and a 5-year survival

(29%) were 16±6.8 and 37±9.89 months, respectively. The mean

survival was found to be 37.15±3.06 months. When survival rate

was evaluated according to localization of tumor, it was lower in

central and left upper lobe tumors compared to other anatomical

localizations (P=0.042). The mean 5-year survival times were

50.00±5.65 months in stage 0 patients, 35.39±5.85 months in stage

1 patients, 37.40±6.89 months in stage 2 patients and 21.44±3.10

months in stage 3 patients.

Conclusion: We can achieve significant survival results by the

anatomical pulmonary resection following neoadjuvant therapy.

Keywords

Non-small cell lung cancer, Neoadjuvant therapy, Chemotherapy, Radiotherapy, Surgery

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