Efficacy of topical clobetasol propionate in the treatment of idiopathic granulomatous mastitis

Year 2018, , 108 - 111, 31.10.2018

Züleyha Yazıcı Özgen Elif Cömert Mustafa Ümit Uğurlu

https://doi.org/10.5472/marumj.474170

Abstract

Objectives: To evaluate the efficacy of topical clobetasol

propionate 0.05% pomade in the treatment of idiopathic

granulomatous mastitis.

Patients and Methods: Twenty-one idiopathic granulomatous

mastitis patients’ clinical and histopathological findings were

retrospectively reviewed. Those patients excluded from other

etiologies were categorized as idiopathic granulomatous mastitis

and treated with topical clobetasol propionate 0.05% pomade as

an initial treatment.

Results: All 21 patients with a final diagnosis of idiopathic

granulomatous mastitis were women with the average age of

36.2+/-5.2 years. Of the 21 patients; erythema, induration and pain

problems of 6 (28.5%) patients totally resolved without recurrence

in 3 months follow-up period. Erythema, induration and pain

problems of 7 (33.5%) patients were minimalized and stay stable

in 3 months follow-up period. The symptoms of 8 (38%) did not

change under topical clobetasol propionate treatment. None of the

patients developed side or adverse effects due to topical steroid

treatment and 6 of 18 patients with non-steroidal anti-inflammatory

drugs (NSAIDs) complained of gastric pain.

Conclusion:Topical steroid treatment is a safe treatment option

for idiopathic granulomatous mastitis patients before systemic

steroid and immunosuppressive treatments and also surgery.

Keywords

Idiopathic granulomatous mastitis, Granulomatous mastitis, Mastitis, Topical Steroid, Steroid

İdiyopatik granülomatöz mastit tedavisinde yerel klobetazol propionatın etkinliği

Abstract

Amaç: İdiyopatik granulomatöz mastit tedavisinde topikal

klobetazol propiyonat %0,05 pomadın etkinliğini değerlendirmek.

Hastalar ve Yöntemler: Klinik ve histopatolojik olarak

idiyopatik granülomatöz mastit tanısı konulan 21 hastanın

dosyası retrospektif olarak incelendi. Altta yatan başka patoloji

saptanmayan hastalar idiyopatik granülomatöz mastit olarak

sınıflandırıldı ve ilk tedavi olarak topikal klobetazol propiyonat %

0,05 pomad uygulandı.

Bulgular: İdiyopatik granülomatöz mastit tanılı 21 kadın

hastanın yaş ortalaması 36,2 ± 5,2 yıldı. Yirmi bir hastanın 6 (%

28,5)’sının eritem, sertlik ve ağrı problemleri tamamen geriledi ve

3 aylık takip döneminde tekrarlamadı. Hastaların 7 (% 33,5)’sinde

eritem, sertlik ve ağrı şikayetleri tama yakın geriledi ve 3 ay

süreli takiplerinde artış izlenmedi. Sekiz (%38) hastada iyileşme

gözlenmedi. Hastalarda yerel steroid tedavisine bağlı yan etki

görülmezken, ek olarak non-steroid antiinflamatuvar (NSAI) ilaç

kullanan 18 hastanın 6’sında mide ağrısı şikayetleri gelişti.

Sonuç: Yerel steroid tedavileri idiyopatik granülomatöz mastit

tedavisinde etkili ve güvenli tedavi seçenekleridir.

Keywords

İdiyopatik granülomatöz mastit, Granülomatöz mastit, Mastit, Yerel steroid, Steroid

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