ENDOKANABİNOİD SİSTEMİN , ENERJİ METABOLİZMASI VE OBEZİTEYE ETKİSİ

Year 2007, Volume: 20 Issue: 3, 202 - 214, 25.06.2015

Emel Tüfekçi Alphan , Nevin Yılmaz

Abstract

Son zamanlarda hint keneviri ve onun majör psikotropik komponenti olan, ∆9-tetrahidrokanabinol, KB1 kanabinoid reseptörleri ve endojen bağlarını içeren endokanabinoidlerin, enerji dengesini kontrol ederek iştahı stimüle ettiği ve vücut ağırlığını artırdığı belirlenmiştir. Hayvan çalışmalarında ve insanlarda yapılan klinik çalışmalarda, endokanabinoid sistemin, besin alımını santral ve periferik mekanizmalarla kontrol ettiği, lipogenez ve yağ birikimini stimüle ettiği gösterilmiştir. Bu makalede, endokanabinoid sistemin oluşumu, reseptörleri, bağları ve bu fizyolojik sistemin enerji metabolizması ve obezite üzerine olan etkisi tartışılmıştır.

Anahtar Kelimeler: Endokanabinoid system, Esrar, Obezite , Enerji metabolizması

Keywords

Endokanabinoid system, Esrar, Obezite , Enerji metabolizması

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