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Year 2005, Volume: 18 Issue: 2, 64 - 70, 29.06.2015

Nermina Jahovic Ayliz Velioğlu Öğünç Esra Güzel Derya Ars Feriha Ercan Gözde Erkanlı Berrak Ç. Yeğen A. Süha Yalçın

Abstract

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Keywords

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References

  • 1. Alphin RS, Vokac VA, Gregory RL, Bolton PM, Tawes JW. Role of intragastric pressure, pH, and pepsin in gastric ulceration in the rat. Gastroenterology 1977; 73: 495-500.
  • 2. Brooks FP. The pathophysiology of peptic ulcer disease. Dig Dis Sci 1985; 30: 15s-29s.
  • 3. Grossman MI. Peptic ulcer: the pathophysiological background. Scand J Gastroenterology 1980; 15 (Suppl. 58): 7-15.
  • 4. Eastwood GL, Kirchner JP. Changes in the fine structure of mouse gastric epithelium produced by ethanol and urea. Gastroenterology 1974; 67: 71-84.
  • 5. Szabo S. Mechanisms of mucosal injury in the stomach and duodenum: time-sequence analysis of morphologic, functional, biochemical and histochemical studies. Scand J Gastroenterol 1987; 127 (suppl.): 21-28.
  • 6. Pihan G, Regilo C, Szabo S. Free radicals and lipid peroxidation in ethanol- or aspirin-induced gastric mucosal injury. Dig Dis Sci 1987; 32: 1395-1401.
  • 7. Kim J-H, Choi S-K, Choi S-Y, Kim H-K, Chang H-I. Suppressive effect of astaxanthin isolated from the xanthophyllomyces dendrorhous mutant on ethanolinduced gastric mucosal injury in rats. Biosci Biotechnol Biochem 2005; 69: 1300-1305.
  • 8. Etzel MR. Manufacture and use of dairy protein fractions. J Nutr 2004; 134: 996-1002.
  • 9. Marshall K. Therapeutic applications of whey protein. Altern Med Rev 2004; 9: 136-156.
  • 10. Yalçın AS. Emerging therapeutic properties of whey proteins and peptides. Curr Pharm Des 2006; 12: 1637- 1643.
  • 11. Bounous G, Letourneau L, Kongshavn PAL. Influence of dietary protein type on the immune system of mice. J Nutr 1983; 113:1415-1421.
  • 12. Bounous G, Gold P. The biological activity of undenatured dietary whey proteins: role of glutathione. Clin Invest Med 1991; 14: 296-309.
  • 13. Rosaneli CF, Bigheti AE, Antonio MA, Carvalho JE, Sgarbieri VC. Efficacy of a whey protein concentrate on the inhibition of stomach ulcerative lesions caused by ethanol ingestion. J Med Food 2002; 5: 221-228.
  • 14. Matsuda H, Pongpiriyadacha Y, Morikawa T, Kashima Y, Nakano K, Yoshikawa M. Protective effects of polygoidal and related compounds on ethanol-induced gastric mucosal lesions in rats: structural requirements and mode of action. Bioorg Med Chem Lett 2002; 12: 477-482.
  • 15. Buege JA, Aust SD. Microsomal lipid peroxidation. Meth Enzymol 1978; 53: 302-311.
  • 16. Hillegass LM, Griswold DE, Brickson B, AlbrightsonWinslow C. Assessment of myeloperoxidase activity in whole rat kidney. J Pharmacol Meth 1990; 24:2 85-295.
  • 17. Ohara Y, Peterson TE, Harrison DG. Hypercholesterolemia increases endothelial superoxide production. J Clin Invest 1993; 91: 2546-2551.
  • 18. Davies GR, Simmond NJ, Stevens TRJ, et al. Helicobacter pylori stimulates antral mucosal reactive oxygen metabolite production in vivo. Gut 1994; 35: 179-185.
  • 19. Haklar G, Yüksel M, Yalçın AS. Chemiluminescence in the measurement of free radicals: theory and application on a tissue injury model. Marmara Med J 1998; 11: 56- 60.
  • 20. Bounous G, Molson J. The antioxidant system. Anticancer Res 2003; 23: 1411-1415.
  • 21. Bafna PA, Balaraman R. Anti-ulcer and anti-oxidant activity of Pepticare, a herbomineral formulation. Phytomedicine 2005; 12: 264-270.
  • 22. Repetto MG, Llesuy SF. Antioxidant properties of natural compounds used in popular medicine for gastric ulcers. Braz J Med Biol Res 2002; 35: 523-534.
  • 23. Piotrowski J, Piotrowski E, Skrodzka D, Slomiany A, Slomiany BL. Gastric mucosal apoptosis induced by ethanol: effect of antiulcer agents. Biochem Molec Biol Int 1997; 42: 247-254.
  • 24. Biswas K, Bandyopadhyay U, Chattopadhyay I, Varadaraj A, Ali E, Banerjee RK. A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical. J Biol Chem 2003; 278: 10933-11001.
  • 25. Korhonen HJ, Reiter B. Production of H2O2 by bovine blood and milk polymorphonuclear leucocytes. Acta Microbiol Pol 1983; 32: 53–64.
  • 26. Bartfay WJ, Davis MT, Medves JM, Lugowski S. Milk whey protein decreases oxygen free radical production in a murine model of chronic iron-overload cardiomyopathy. Can J Cardiol 2003; 19: 1163–1168.
  • 27. Hiraishi H, Shimada T, Ivey KJ, Terano A. Role of antioxidant defenses against ethanol-induced damage in cultured rat gastric epithelial cells. J Pharmacol Exp Ther 1999; 289: 103-109.
  • 28. Dial EJ, Lichtenberger LM. Milk protection against experimental ulcerogenesis in rats. Dig Dis Sci 1987; 32: 1145-1150.
  • 29. Kivinen A, Salminen S, Homer D, Vapaatalo H. Gastroprotective effect of milk phospholipids, butter serum lipids and butter serum on ethanol and acetylsalicylic acid induced ulcers in rats. Milchwissenschaft 1992; 47: 573–575.
  • 30. Koo MW. The effects of milk and calcium on ethanolinduced gastric mucosal damage. Pharmacol Res 1994; 29: 217-224.
  • 31. Matsumoto H, Shimokawa Y, Ushida Y, Toida T, Hayasawa H. New biological function of bovine alphalactalbumin: protective effect against ethanol- and stress-induced gastric mucosal injury in rats. Biosci Biotechnol Biochem 2001; 65: 1104-1111.
  • 32. Clarke J, Butler R, Howarth G, Read L, Regester G. Exposure of oral mucosa to bioactive milk factors reduces severity of chemotherapy-induced mucositis in the hamster. Oral Oncol 2002; 38: 478-485.
  • 33. Zimmerman BJ, Grisham MB, Granger DN. Role of oxidants in ischemia–reperfusion induced granulocyte infiltration. Amer J Physiol 1990; 258: G185–G190.
  • 34. Sullivan GW, Sarembock IJ, Linden J. The role of inflammation in vascular diseases. J Leuk Biol 2000; 67: 591–602.
  • 35. Kettle AJ, Winterbourn CC. Myeloperoxidase: a key regulator of neutrophil oxidant production. Redox Report 1997; 3: 3–15.

SÜT SERUMU PROTEİNLERİ UYGULAMASININ ETANOLLE OLUŞTURULAN MİDE ÜLSERİNDE MİDE VE KARACİĞER OKSİDATİF HASARI ÜZERİNE NÖTROFİL ARACILI ETKİSİ

Year 2005, Volume: 18 Issue: 2, 64 - 70, 29.06.2015

Nermina Jahovic Ayliz Velioğlu Öğünç Esra Güzel Derya Ars Feriha Ercan Gözde Erkanlı Berrak Ç. Yeğen A. Süha Yalçın

Abstract

Amaç: Süt serumu proteinlerinin antioksidan etkileri vardır. Bu çalışmada, süt serumu proteinlerinin etanolle oluşturulan oksidatif mide
ve karaciğer hasarındaki koruyucu etkileri değerlendirildi.
Yöntem: Mide dokusunda reaktif oksijen türlerinin oluşumu kemilüminesans yöntemiyle takip edildi. Karaciğer ve mide dokuları
histopatolojik olarak değerlendirilirken, lipit peroksidasyonu göstergesi olarak malondialdehit düzeyleri ve nötrofil infiltrasyonu için
miyeloperoksidaz aktivitesi ölçüldü.
Bulgular: Süt serumu proteinleriyle ön beslenmenin etanolle oluşturulan mide ve karaciğer hasarında nötrofil infiltrasyonunu ve
sitotoksik serbest radikal oluşumunu önleyerek koruyucu etki yaptığı gözlendi.
Sonuç: Peyniraltı suyu kaynaklı bir ürün ile beslenmenin gastrik lezyonların tedavisinda yararlı bir seçenek oluşturabileceği
düşünülmektedir.

Keywords

Süt serumu proteinleri Etanol Mide ve karaciğer oksidatif hasarı

References

  • 1. Alphin RS, Vokac VA, Gregory RL, Bolton PM, Tawes JW. Role of intragastric pressure, pH, and pepsin in gastric ulceration in the rat. Gastroenterology 1977; 73: 495-500.
  • 2. Brooks FP. The pathophysiology of peptic ulcer disease. Dig Dis Sci 1985; 30: 15s-29s.
  • 3. Grossman MI. Peptic ulcer: the pathophysiological background. Scand J Gastroenterology 1980; 15 (Suppl. 58): 7-15.
  • 4. Eastwood GL, Kirchner JP. Changes in the fine structure of mouse gastric epithelium produced by ethanol and urea. Gastroenterology 1974; 67: 71-84.
  • 5. Szabo S. Mechanisms of mucosal injury in the stomach and duodenum: time-sequence analysis of morphologic, functional, biochemical and histochemical studies. Scand J Gastroenterol 1987; 127 (suppl.): 21-28.
  • 6. Pihan G, Regilo C, Szabo S. Free radicals and lipid peroxidation in ethanol- or aspirin-induced gastric mucosal injury. Dig Dis Sci 1987; 32: 1395-1401.
  • 7. Kim J-H, Choi S-K, Choi S-Y, Kim H-K, Chang H-I. Suppressive effect of astaxanthin isolated from the xanthophyllomyces dendrorhous mutant on ethanolinduced gastric mucosal injury in rats. Biosci Biotechnol Biochem 2005; 69: 1300-1305.
  • 8. Etzel MR. Manufacture and use of dairy protein fractions. J Nutr 2004; 134: 996-1002.
  • 9. Marshall K. Therapeutic applications of whey protein. Altern Med Rev 2004; 9: 136-156.
  • 10. Yalçın AS. Emerging therapeutic properties of whey proteins and peptides. Curr Pharm Des 2006; 12: 1637- 1643.
  • 11. Bounous G, Letourneau L, Kongshavn PAL. Influence of dietary protein type on the immune system of mice. J Nutr 1983; 113:1415-1421.
  • 12. Bounous G, Gold P. The biological activity of undenatured dietary whey proteins: role of glutathione. Clin Invest Med 1991; 14: 296-309.
  • 13. Rosaneli CF, Bigheti AE, Antonio MA, Carvalho JE, Sgarbieri VC. Efficacy of a whey protein concentrate on the inhibition of stomach ulcerative lesions caused by ethanol ingestion. J Med Food 2002; 5: 221-228.
  • 14. Matsuda H, Pongpiriyadacha Y, Morikawa T, Kashima Y, Nakano K, Yoshikawa M. Protective effects of polygoidal and related compounds on ethanol-induced gastric mucosal lesions in rats: structural requirements and mode of action. Bioorg Med Chem Lett 2002; 12: 477-482.
  • 15. Buege JA, Aust SD. Microsomal lipid peroxidation. Meth Enzymol 1978; 53: 302-311.
  • 16. Hillegass LM, Griswold DE, Brickson B, AlbrightsonWinslow C. Assessment of myeloperoxidase activity in whole rat kidney. J Pharmacol Meth 1990; 24:2 85-295.
  • 17. Ohara Y, Peterson TE, Harrison DG. Hypercholesterolemia increases endothelial superoxide production. J Clin Invest 1993; 91: 2546-2551.
  • 18. Davies GR, Simmond NJ, Stevens TRJ, et al. Helicobacter pylori stimulates antral mucosal reactive oxygen metabolite production in vivo. Gut 1994; 35: 179-185.
  • 19. Haklar G, Yüksel M, Yalçın AS. Chemiluminescence in the measurement of free radicals: theory and application on a tissue injury model. Marmara Med J 1998; 11: 56- 60.
  • 20. Bounous G, Molson J. The antioxidant system. Anticancer Res 2003; 23: 1411-1415.
  • 21. Bafna PA, Balaraman R. Anti-ulcer and anti-oxidant activity of Pepticare, a herbomineral formulation. Phytomedicine 2005; 12: 264-270.
  • 22. Repetto MG, Llesuy SF. Antioxidant properties of natural compounds used in popular medicine for gastric ulcers. Braz J Med Biol Res 2002; 35: 523-534.
  • 23. Piotrowski J, Piotrowski E, Skrodzka D, Slomiany A, Slomiany BL. Gastric mucosal apoptosis induced by ethanol: effect of antiulcer agents. Biochem Molec Biol Int 1997; 42: 247-254.
  • 24. Biswas K, Bandyopadhyay U, Chattopadhyay I, Varadaraj A, Ali E, Banerjee RK. A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical. J Biol Chem 2003; 278: 10933-11001.
  • 25. Korhonen HJ, Reiter B. Production of H2O2 by bovine blood and milk polymorphonuclear leucocytes. Acta Microbiol Pol 1983; 32: 53–64.
  • 26. Bartfay WJ, Davis MT, Medves JM, Lugowski S. Milk whey protein decreases oxygen free radical production in a murine model of chronic iron-overload cardiomyopathy. Can J Cardiol 2003; 19: 1163–1168.
  • 27. Hiraishi H, Shimada T, Ivey KJ, Terano A. Role of antioxidant defenses against ethanol-induced damage in cultured rat gastric epithelial cells. J Pharmacol Exp Ther 1999; 289: 103-109.
  • 28. Dial EJ, Lichtenberger LM. Milk protection against experimental ulcerogenesis in rats. Dig Dis Sci 1987; 32: 1145-1150.
  • 29. Kivinen A, Salminen S, Homer D, Vapaatalo H. Gastroprotective effect of milk phospholipids, butter serum lipids and butter serum on ethanol and acetylsalicylic acid induced ulcers in rats. Milchwissenschaft 1992; 47: 573–575.
  • 30. Koo MW. The effects of milk and calcium on ethanolinduced gastric mucosal damage. Pharmacol Res 1994; 29: 217-224.
  • 31. Matsumoto H, Shimokawa Y, Ushida Y, Toida T, Hayasawa H. New biological function of bovine alphalactalbumin: protective effect against ethanol- and stress-induced gastric mucosal injury in rats. Biosci Biotechnol Biochem 2001; 65: 1104-1111.
  • 32. Clarke J, Butler R, Howarth G, Read L, Regester G. Exposure of oral mucosa to bioactive milk factors reduces severity of chemotherapy-induced mucositis in the hamster. Oral Oncol 2002; 38: 478-485.
  • 33. Zimmerman BJ, Grisham MB, Granger DN. Role of oxidants in ischemia–reperfusion induced granulocyte infiltration. Amer J Physiol 1990; 258: G185–G190.
  • 34. Sullivan GW, Sarembock IJ, Linden J. The role of inflammation in vascular diseases. J Leuk Biol 2000; 67: 591–602.
  • 35. Kettle AJ, Winterbourn CC. Myeloperoxidase: a key regulator of neutrophil oxidant production. Redox Report 1997; 3: 3–15.
There are 35 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Nermina Jahovic This is me

Ayliz Velioğlu Öğünç This is me

Esra Güzel This is me

Derya Ars This is me

Feriha Ercan This is me

Gözde Erkanlı This is me

Berrak Ç. Yeğen This is me

A. Süha Yalçın

Publication Date June 29, 2015
Published in Issue Year 2005 Volume: 18 Issue: 2

Cite

APA Jahovic, N., Velioğlu Öğünç, A., Güzel, E., Ars, D., et al. (2015). SÜT SERUMU PROTEİNLERİ UYGULAMASININ ETANOLLE OLUŞTURULAN MİDE ÜLSERİNDE MİDE VE KARACİĞER OKSİDATİF HASARI ÜZERİNE NÖTROFİL ARACILI ETKİSİ. Marmara Medical Journal, 18(2), 64-70.
AMA Jahovic N, Velioğlu Öğünç A, Güzel E, Ars D, Ercan F, Erkanlı G, Yeğen BÇ, Yalçın AS. SÜT SERUMU PROTEİNLERİ UYGULAMASININ ETANOLLE OLUŞTURULAN MİDE ÜLSERİNDE MİDE VE KARACİĞER OKSİDATİF HASARI ÜZERİNE NÖTROFİL ARACILI ETKİSİ. Marmara Med J. August 2015;18(2):64-70.
Chicago Jahovic, Nermina, Ayliz Velioğlu Öğünç, Esra Güzel, Derya Ars, Feriha Ercan, Gözde Erkanlı, Berrak Ç. Yeğen, and A. Süha Yalçın. “SÜT SERUMU PROTEİNLERİ UYGULAMASININ ETANOLLE OLUŞTURULAN MİDE ÜLSERİNDE MİDE VE KARACİĞER OKSİDATİF HASARI ÜZERİNE NÖTROFİL ARACILI ETKİSİ”. Marmara Medical Journal 18, no. 2 (August 2015): 64-70.
EndNote Jahovic N, Velioğlu Öğünç A, Güzel E, Ars D, Ercan F, Erkanlı G, Yeğen BÇ, Yalçın AS (August 1, 2015) SÜT SERUMU PROTEİNLERİ UYGULAMASININ ETANOLLE OLUŞTURULAN MİDE ÜLSERİNDE MİDE VE KARACİĞER OKSİDATİF HASARI ÜZERİNE NÖTROFİL ARACILI ETKİSİ. Marmara Medical Journal 18 2 64–70.
IEEE N. Jahovic, A. Velioğlu Öğünç, E. Güzel, D. Ars, F. Ercan, G. Erkanlı, B. Ç. Yeğen, and A. S. Yalçın, “SÜT SERUMU PROTEİNLERİ UYGULAMASININ ETANOLLE OLUŞTURULAN MİDE ÜLSERİNDE MİDE VE KARACİĞER OKSİDATİF HASARI ÜZERİNE NÖTROFİL ARACILI ETKİSİ”, Marmara Med J, vol. 18, no. 2, pp. 64–70, 2015.
ISNAD Jahovic, Nermina et al. “SÜT SERUMU PROTEİNLERİ UYGULAMASININ ETANOLLE OLUŞTURULAN MİDE ÜLSERİNDE MİDE VE KARACİĞER OKSİDATİF HASARI ÜZERİNE NÖTROFİL ARACILI ETKİSİ”. Marmara Medical Journal 18/2 (August 2015), 64-70.
JAMA Jahovic N, Velioğlu Öğünç A, Güzel E, Ars D, Ercan F, Erkanlı G, Yeğen BÇ, Yalçın AS. SÜT SERUMU PROTEİNLERİ UYGULAMASININ ETANOLLE OLUŞTURULAN MİDE ÜLSERİNDE MİDE VE KARACİĞER OKSİDATİF HASARI ÜZERİNE NÖTROFİL ARACILI ETKİSİ. Marmara Med J. 2015;18:64–70.
MLA Jahovic, Nermina et al. “SÜT SERUMU PROTEİNLERİ UYGULAMASININ ETANOLLE OLUŞTURULAN MİDE ÜLSERİNDE MİDE VE KARACİĞER OKSİDATİF HASARI ÜZERİNE NÖTROFİL ARACILI ETKİSİ”. Marmara Medical Journal, vol. 18, no. 2, 2015, pp. 64-70.
Vancouver Jahovic N, Velioğlu Öğünç A, Güzel E, Ars D, Ercan F, Erkanlı G, Yeğen BÇ, Yalçın AS. SÜT SERUMU PROTEİNLERİ UYGULAMASININ ETANOLLE OLUŞTURULAN MİDE ÜLSERİNDE MİDE VE KARACİĞER OKSİDATİF HASARI ÜZERİNE NÖTROFİL ARACILI ETKİSİ. Marmara Med J. 2015;18(2):64-70.