Abstract
Objectives: The ischemia-modified albumin (IMA) test is a promising indicator of myocardial ischemia in the early diagnosis of the acute coronary syndrome (ACS). Recent studies examining alterations in IMA levels caused by myocardial ischemia that develops during exercise have shown contradictory results. There has been an increase in severe exercise-related cardiac events in football. We therefore, assessed IMA levels before and after exercise in professional soccer players in order to examine the effect of the exercise on IMA levels. Methods: Blood was collected from professional soccer players before and after exercise. IMA levels were measured by using spectrophotometric methods, and the albumin levels were measured in an autoanalyzer. Results: The average pre- and post exercise IMA levels of 16 soccer players were found to be 0.438±0.071 and 0.386±0.069, respectively. The pre- and post exercise albumin levels of the same group were 4.08±0.20 g/dL and 4.21±0.19 g/dL, respectively. There was a strong negative correlation between post exercise IMA and albumin levels, which was statistically significant (r = -0.535. p = 0.033).Conclusion: IMA levels should be examined not only in noncardiac pathologies, but also in specific serum albumin concentrations and in individuals practicing vigorous sport activities
References
- 1. Roy D, Quiles J, Aldama G, et al. Ischemia Modified Albumin for the assessment of patients presenting to the emergency department with acute chest pain but normal or non-diagnostic 12-lead electrocardiograms and negative cardiac troponin T. Int J Cardiol 2004; 97: 297-301. doi:10.1016/ j.ijcard.2004.05.042
- 2. Christenson RH, Dull SH, Sanhai WR, et al. Characteristics of an Albumin Cobalt Binding Test for assessment of acute coronary syndrome patients: A Multicenter Study. Clin Chem 2001; 47: 464-70.
- 3. Lippi G, Montagnana M, Guidi GC. Predicting cardiac outcome. Can Med Assoc J 2005; 173: 1206-7. doi:10.1503/cmaj.1050168
- 4. Kurz K, Voelker R, Zdunek D, et al. Effect of stress-induced reversible ischemia on serum concentrations of ischemia-modified albumin, natriuretic peptides and placental growth factor. Clin Res Cardiol 2007; 96: 152-9. doi:10.1007/s00392-007-0469-5
- 5. Piechota WN, Wierzbowski R, Piechota WT, Bejm J, Gielerak G. N-terninal pro-brain natriuretic peptide (NT-proBNP) and ischemia modified albumin (IMA) in exercise induced ischemia in patients with stable coronary artery disease. Pol Arch Med Wewn 2006; 116: 640-7.
- 6. Bar-Or D, Lau E, Winkler JV. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia-A preliminary report. The J Emerg Med 2000; 19: 311-3. doi:10.1016/ S0736-4679(00)00255-9
- 7. Corrado D, Migliore F, Basso C, Thiene G. Exercise and the risk of sudden cardiac death. Herz 2006; 31: 553-8. doi:10.1007/s00059-006- 2885-8
- 8. Siasos G, Tousoulis D, Athanasiou D, et al. Novel risk factors related to stable angina. Curr Pharm Des 2012; 18: [Epub ahead of print].
- 9. Kehl DW, Iqbal N, Fard A, Kipper BA, De La Parra Landa A, Maisel AS. Biomarkers in acute myocardial injury. Transl Res 2012; 159: 252-64. doi:10.1016/j.trsl.2011.11.002
- 10. Zhong Y, Wang N, Xu H, Hou X, Xu P, Zhou Z. Ischemia-modified albumin in stable coronary atherosclerotic heart disease: clinica diagnosis and risk stratification. Coron Artery Dis 2012; 23: 538-41. doi: 10.1097/MCA.0b013e328358a5e9
- 11. Montagnana M, Lippi G, Regis D, et al. Evaluation of cardiac involvement following major orthopedic surgery. Clin Chem Lab Med 2006; 44: 1340-6. doi:10.1515/CCLM.2006.256
- 12. Refaai MA, Wright RW, Parvin CA, Grouowski AM, Scott MG, Eby CS. Ischemia-modified albumin increases after skeletal muscle ischemia during arlhroscopic knee surgery. Clin Chim Acta 2006; 366: 264-8. doi:10.1016/j.cca.2005.10.020
- 13. Troxler M, Thompson D, Homer-Vanniasinkam S. Ischaemic skeletal muscle increases serum ischaemia modified albumin. Eur J Vasc Endovasc Surg 2006; 31: 164-9. doi:10.1016/j.ejvs.2005.06.019
- 14. Montagnana M, Lippi G, Volpe A, et al. Evaluation of cardiac laboratory markers in patients with systemic sclerosis. Clin Biochem 2006; 39: 913-7. doi:10.1016/j.clinbiochem.2006.03.016
- 15. Apple FS, Quist HE, Otto AP, Mathews WE, Murakami MM. Release characteristics of cardiac biomarkers and ischemia-modified albumin as measured by the albumin cobalt-binding test after a marathon race. Clin Chem 2002; 48: 1097-100.
- 16. Middleton N, Shave R, George K, et al. Novel application of flow propagation velocity and ischemia-modified albumin in analysis of postexercise cardiac function in man. Exp Physiol 2006; 91: 511-9. doi:10.1113/ expphysiol.2005.032631
- 17. Roy D, Quiles J, Sharma R, et al. Ischemia-modified albumin concentrations in patients with peripheral vascular disease and exercise-induced skeletal muscle ischemia. Clin Chem 2004; 50: 1656-60. doi:10.1373/clinchem.2004. 031690
- 18. Zapico-Muniz E, Santalo-Bel M, Merce-Muntanola J, et al. Ischemiamodified albumin during skeletal muscle ıschemia. Clin Chem 2004; 50: 1063-65. doi:10.1373/clinchem.2003.027789
- 19. Van der Zee PM, Verberne HJ, Van Straalen JP, et al. Ischemia-modified albumin measurements in symptom-limited exercise myocardial perfusion scintigraphy reflect serum albumin concentrations but not myocardial ischemia. Clin Chem 2005; 51: 1744-6. doi:10.1373/ clinchem.2005. 054635
- 20. Gunduz A, Turkmen S, Turedi S, et al. Time-dependent variations in ischemia modified albumin levels in mesenteric ischemia. Acad Emerg Med 2009; 16:539-43. doi:10.1111/j.1553-2712.2009.00414.x
Abstract
Amaç: İskemi modifiye albumin (IMA), akut koroner sendromun
erken tanısında myokard iskemisinin bir belirteci olarak umud
vadeden bir testtir. Ancak egzersiz sırasında gelişen iskeminin IMA
düzeylerinde yolaçtığı değişimi inceleyen son çalışmalar çelişkili
sonuçlar saptamıştır. Öte yandan futbolcularda egzersizle ilgili ciddi
kardiyak olaylarda da artış vardır. Bu nedenle biz IMA düzeylerine
egzersizin etkisini araştırmak için profesyonel futbol oyuncularında
egzersiz öncesi ve sonrası IMA düzeylerini değerlendirdik.
Yöntem: Profesyonel futbolculardan egzersiz öncesi ve sonrası
kan örnekleri toplandı. IMA düzeyleri spektrofotometrik metodların
kullanımı ile ve albumin düzeyleri de otomatik analizör cihazında
ölçüldü.
Bulgular: On altı futbolcunun egzersiz öncesi ve sonrası
ortalama IMA düzeyleri sırasıyla 0.438±0.071 and 0.386±0.069
olarak saptandı. Aynı grubun egzersiz öncesi ve sonrası ortalama
albumin düzeyleri ise sırasıyla 4.08±0.20 g/dL and 4.21±0.19 g/dL
olarak ölçüldü. Egzersiz sonrası IMA ve albumin düzeyleri arasında
istatistiksel olarak anlamlı güçlü bir negatif korelasyon vardı
(r = -0.535. p = 0.033).
Sonuç: IMA düzeyleri sadece kardiyak olmayan patolojilerde
değil özgül serum albumin konsantrasyonlarında ve şiddetli spor
aktivitelerinde bulunan bireylerde de değerlendirilmelidir.
Keywords
References
- 1. Roy D, Quiles J, Aldama G, et al. Ischemia Modified Albumin for the assessment of patients presenting to the emergency department with acute chest pain but normal or non-diagnostic 12-lead electrocardiograms and negative cardiac troponin T. Int J Cardiol 2004; 97: 297-301. doi:10.1016/ j.ijcard.2004.05.042
- 2. Christenson RH, Dull SH, Sanhai WR, et al. Characteristics of an Albumin Cobalt Binding Test for assessment of acute coronary syndrome patients: A Multicenter Study. Clin Chem 2001; 47: 464-70.
- 3. Lippi G, Montagnana M, Guidi GC. Predicting cardiac outcome. Can Med Assoc J 2005; 173: 1206-7. doi:10.1503/cmaj.1050168
- 4. Kurz K, Voelker R, Zdunek D, et al. Effect of stress-induced reversible ischemia on serum concentrations of ischemia-modified albumin, natriuretic peptides and placental growth factor. Clin Res Cardiol 2007; 96: 152-9. doi:10.1007/s00392-007-0469-5
- 5. Piechota WN, Wierzbowski R, Piechota WT, Bejm J, Gielerak G. N-terninal pro-brain natriuretic peptide (NT-proBNP) and ischemia modified albumin (IMA) in exercise induced ischemia in patients with stable coronary artery disease. Pol Arch Med Wewn 2006; 116: 640-7.
- 6. Bar-Or D, Lau E, Winkler JV. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia-A preliminary report. The J Emerg Med 2000; 19: 311-3. doi:10.1016/ S0736-4679(00)00255-9
- 7. Corrado D, Migliore F, Basso C, Thiene G. Exercise and the risk of sudden cardiac death. Herz 2006; 31: 553-8. doi:10.1007/s00059-006- 2885-8
- 8. Siasos G, Tousoulis D, Athanasiou D, et al. Novel risk factors related to stable angina. Curr Pharm Des 2012; 18: [Epub ahead of print].
- 9. Kehl DW, Iqbal N, Fard A, Kipper BA, De La Parra Landa A, Maisel AS. Biomarkers in acute myocardial injury. Transl Res 2012; 159: 252-64. doi:10.1016/j.trsl.2011.11.002
- 10. Zhong Y, Wang N, Xu H, Hou X, Xu P, Zhou Z. Ischemia-modified albumin in stable coronary atherosclerotic heart disease: clinica diagnosis and risk stratification. Coron Artery Dis 2012; 23: 538-41. doi: 10.1097/MCA.0b013e328358a5e9
- 11. Montagnana M, Lippi G, Regis D, et al. Evaluation of cardiac involvement following major orthopedic surgery. Clin Chem Lab Med 2006; 44: 1340-6. doi:10.1515/CCLM.2006.256
- 12. Refaai MA, Wright RW, Parvin CA, Grouowski AM, Scott MG, Eby CS. Ischemia-modified albumin increases after skeletal muscle ischemia during arlhroscopic knee surgery. Clin Chim Acta 2006; 366: 264-8. doi:10.1016/j.cca.2005.10.020
- 13. Troxler M, Thompson D, Homer-Vanniasinkam S. Ischaemic skeletal muscle increases serum ischaemia modified albumin. Eur J Vasc Endovasc Surg 2006; 31: 164-9. doi:10.1016/j.ejvs.2005.06.019
- 14. Montagnana M, Lippi G, Volpe A, et al. Evaluation of cardiac laboratory markers in patients with systemic sclerosis. Clin Biochem 2006; 39: 913-7. doi:10.1016/j.clinbiochem.2006.03.016
- 15. Apple FS, Quist HE, Otto AP, Mathews WE, Murakami MM. Release characteristics of cardiac biomarkers and ischemia-modified albumin as measured by the albumin cobalt-binding test after a marathon race. Clin Chem 2002; 48: 1097-100.
- 16. Middleton N, Shave R, George K, et al. Novel application of flow propagation velocity and ischemia-modified albumin in analysis of postexercise cardiac function in man. Exp Physiol 2006; 91: 511-9. doi:10.1113/ expphysiol.2005.032631
- 17. Roy D, Quiles J, Sharma R, et al. Ischemia-modified albumin concentrations in patients with peripheral vascular disease and exercise-induced skeletal muscle ischemia. Clin Chem 2004; 50: 1656-60. doi:10.1373/clinchem.2004. 031690
- 18. Zapico-Muniz E, Santalo-Bel M, Merce-Muntanola J, et al. Ischemiamodified albumin during skeletal muscle ıschemia. Clin Chem 2004; 50: 1063-65. doi:10.1373/clinchem.2003.027789
- 19. Van der Zee PM, Verberne HJ, Van Straalen JP, et al. Ischemia-modified albumin measurements in symptom-limited exercise myocardial perfusion scintigraphy reflect serum albumin concentrations but not myocardial ischemia. Clin Chem 2005; 51: 1744-6. doi:10.1373/ clinchem.2005. 054635
- 20. Gunduz A, Turkmen S, Turedi S, et al. Time-dependent variations in ischemia modified albumin levels in mesenteric ischemia. Acad Emerg Med 2009; 16:539-43. doi:10.1111/j.1553-2712.2009.00414.x
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | September 30, 2015 |
| Published in Issue | Year 2013 Volume: 26 Issue: 1 |