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Ferhat Ekinci; Arzu Uzuner; Merder Demet; Bilge Turgut; Niyazi Tosun

doi:10.5472/MMJoa.2803.02

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Year 2015, Volume: 28 Issue: 3, 129 - 134, 28.11.2015

Ferhat Ekinci Arzu Uzuner , Merder Demet Bilge Turgut Niyazi Tosun

https://doi.org/10.5472/MMJoa.2803.02

Cited By: 2

Abstract

Keywords

References

1. WHO: Obesity Preventing And Managing The Global Epidemic. Report of WHO Technical Report Series 894. Geneva: World Health Organization 2000. http://www. who.int/nutrition/publications/obesity/WHO_TRS_894/en/ 19/04/2015.
2. Klish WJ. Comorbidities and complications of obesity in children and adolescents. http://0210c7oi7.y.http.www. uptodate.com Literature review current through: Oct 2015.
3. Torun E, Cindemir E, Tolga Özgen İ, Öktem F. Subclinical hypothyroidism in obese children. Dicle Medical Journal 2013; 40 : 5-8. doi: 10.5798/diclemedj.0921.2013.01.0215
4. Stichel H, I’Allemand D, Gruters A. Thyroid function and obesity in children and adolescents. Horm Res 2000;54:14-9. doi:10.1159/000063431
5. Dekelbab BH, Abou Ouf HA, Jain I. Prevalence of elevated thyroid-stimulating hormone levels in obese children and adolescents. Endocr Pract 2010;16:187-90. doi: 10.4158/ EP09176.
6. Günöz H, Saner G, Demirkol M, Gökçay G, Hüner G, Garibağaoğlu M. Beslenme ve Beslenme Bozuklukları, “Pediatri” içinde Olcay Neyzi, Türkan Ertuğrul, editor. 3. Baskı, 1. Cilt. Ankara: Nobel Tıp Kitapevleri, 2002: 221-6.
7. Kapelari K, Kirchlechner C, Hogler W, et al. Pediatric reference intervals for thyroid hormone levels from birth to adulthood: a retrospective study. BMC Endocr Disord 2008;27:8-15. doi: 10.1186/1472-6823-8-15.
8. Radetti G, Kleon W, Buzi F, et al. Thyroid function and structure are affected in childhood obesity. J Clin Endocrinol Metab 2008;93:4749-54. doi: 10.1210/jc.2008-0823.
9. Grandone A, Santoro N, Coppola F, Calabrò P, Perrone L, Del Giudice EM. Thyroid function derangement and childhood obesity: an Italian experience. BMC Endocr Disord 2010;10:8. doi: 10.1186/1472-6823-10-8.
10. Bhowmick SK, Dasari G, Levens KL, Rettig KR. The prevalence of elevated serum thyroid stimulating hormone in childhood/adolescent obesity and of autoimmune thyroid diseases in a subgroup. J Nat Med Ass 2007;99:773-6. http:// www.ncbi.nlm.nih.gov/pmc/articles/PMC2574343/ Accessed on 11.082015
11. Mutlu RG, Özsu E, Çizmecioğlu FM. Şişman çocuklarda hafif TSH yüksekliği: Nasıl bir sorun? Türk Ped Arş 2011;46:33-6.
12. Kumar H, Verma A, Muthukrishnan J, et al. Obesity and thyrotropinemia. Indian J Pediatr 2009;76:933-5.
13. Knudsen N, Laurberg P, Rasmussen LB, Bülow I, Perrild H, Ovesen L, Jørgensen T. Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. J. Clin Endocrinol Metab 2005;90:4019-24. doi: 10.1210/jc.2004-2225.
14. Marras V, Casini MR, Pilia S, et al. Thyroid function in obese children and adolescents. Horm Res Paediatr 2010;73:193-7. doi:10.1159/000284361
15. Reinehr T, Hinney A, de Sousa G, et al. Definable somatic disorders in overweight children and adolescents. J Pediatr 2007;150:618-22.
16. Lloyd RV, Jin L, Tsumanuma I, et al. Leptin and leptin receptor in anterior pituitary function. Pituitary 2001;4:33-47.
17. Ortiga-Carvalho TM, Oliveira KJ, Soares BA, et al. The role of leptin in the regulation of TSH secretion in the fed state: in vivo and in vitro studies, J Endocrinol. 2002;174:121-5. http://joe.endocrinology-journals.org/content/174/1/121.full. pdf Accessed on 11.08.2015
18. Fox S. C, Pencina MJ, D’Agostino RB, et al. Relations of thyroid function to body weight. Cross-sectional and longitudinal observations in a community-based sample. Arch Intern Med 2008;168:587-92. doi:10.1001/archinte.168.6.587.
19. Ross DS. Thyroid function and the metabolic syndrome. J Clin Endocrinol Metab 2007;92:491-6.
20. Reinehr T, De Sousa G, Andler W. Hyperthyrotropinemia in obese children is reversible after weight loss and is not related to lipids. J Clin Endocrinol Metab 2006;91:3088-91.
21. Holst-Schumacher I, Nuñez-Rivas H, Monge-Rojas R, Barrantes-Santamaría M. Components of the metabolic syndrome among a sample of overweight and obese Costa Rican schoolchildren. Food Nutr Bull 2009 ;30:161-70.
22. Pacifico L, Bonci E, Ferraro F, et al. Hepatic steatosis and thyroid function tests in overweight and obese children. International Journal of Endocrinology 2013:38:10-4. doi: 10.1155/2013/381014.
23. Aeberli I, Jung A, Murer SB, et al. During rapid weight loss in obese children, reductions in TSH predict improvements in insulin sensitivity independent of changes in body weight or fat. J Clin Endocrinol Metab 2010;95:5412-8. doi: 10.1210/ jc.2010-1169.
24. Eliakim A, Barzilai M, Wolach B, Nemet D. Should we treat elevated thyroid stimulating hormone levels in obese children and adolescents? Int J Pediatr Obes 2006;1:217-21.
25. Sari R, Balci MK, Altunbas H, et al. The effect of body weight and weight loss on thyroid volume and function in obese women. Clin Endocrinol 2003;59:258-62. doi: 10.1046/j.1365-2265.2003.01836.x.
26. Shalitin S, Yackobovitch-Gavan M, Phillip M. Prevalence of thyroid dysfunction in obese children and adolescents before and after weight reduction and its relation to other metabolic parameters. Horm Res 2009;71:155-61. doi: 10.1159/000197872.
27. Santos MI, Limbert C, Marques FC, Rosário F, Lopes L. Childhood obesity, thyroid function, and insulin resistance – is there a link? A longitudinal study.J Pediatr Endocrinol Metab. 2015 May;28(5-6):557-62. doi: 10.1515/jpem-2014-0319.
28. Lazar L, Frumkin RB, Battat E, Lebenthal Y, Phillip M, Meyerovitch J. Natural history of thyroid function tests over 5 years in a large pediatric cohort. J Clin Endocrinol Metab 2009;94:1678-82. doi: 10.1210/jc.2008-2615.
29. Kaptein EM, Beale E, Chan LS. Thyroid hormone therapy for obesity and nonthyroidal illnesses: a systematic review. J Clin Endocrinol Metab 2009;94:3663-75. doi: 10.1210/jc.2009- 0899

Thyroid hormones and BMI in obese children: One year follow up results

Year 2015, Volume: 28 Issue: 3, 129 - 134, 28.11.2015

Ferhat Ekinci Arzu Uzuner , Merder Demet Bilge Turgut Niyazi Tosun

https://doi.org/10.5472/MMJoa.2803.02

Cited By: 2

Abstract

Amaç: Bu çalışmanın amacı tiroid hormon düzeyleri ile obezite,
lipid düzeyleri ve ağırlık değişiklikleri arasındaki ilişkiyi
araştırmaktır.
Hastalar ve Yöntemler: Beş ve onbir yaş aralığında
normal, fazla kilolu ve obez çocukların TSH, sT4, lipid profili ve
otoimmün antikor değerlerine bakılmıştır. TSH düzeyi yüksek olan
çocuklar herhangi bir müdahale yapılmadan bir yıl sonra yeniden
değerlendirilmiştir.
Bulgular: Çalışmada 300 çocuk (126 obez, 74 fazla kilolu,
100 normal kilolu) değerlendirilmiştir. Yüksek TSH düzeyi sıklığı
normal kilolu grupta %1.0, fazla kilolu grupta %9.5 ve obez grupta
%11.9’dur (p=0.007). Bütün gruplarda sT4 düzeyleri normal
bulunmuştur. Çocukların hiçbirinde otoimmun antikorlar pozitif
değildir. Yüksek TSH’lı çocuklar normal TSH’lı çocuklara göre
daha yüksek trigliserid düzeylerine sahiptir (p=0.028). Bir yıl sonra
yapılan değerlendirmede, VKİ’de anlamlı düşüşle birlikte TSH
düzeyinde de anlamlı bir düşüş saptanmıştır.
Sonuç: TSH düzeyleri obez ve fazla kilolu çocuklarda yüksek
olabilir. TSH yüksekliği olan obez ve fazla kilolu çocukların
farmakolojik olarak tedavi edilmesine gerek yoktur, kilo vermek
TSH düzeylerinin anlamlı olarak azalmasını sağlar.

Keywords

TSH, VKİ, Çocuk, Obezite, Fazla kilolu, Tiroid

References

1. WHO: Obesity Preventing And Managing The Global Epidemic. Report of WHO Technical Report Series 894. Geneva: World Health Organization 2000. http://www. who.int/nutrition/publications/obesity/WHO_TRS_894/en/ 19/04/2015.
2. Klish WJ. Comorbidities and complications of obesity in children and adolescents. http://0210c7oi7.y.http.www. uptodate.com Literature review current through: Oct 2015.
3. Torun E, Cindemir E, Tolga Özgen İ, Öktem F. Subclinical hypothyroidism in obese children. Dicle Medical Journal 2013; 40 : 5-8. doi: 10.5798/diclemedj.0921.2013.01.0215
4. Stichel H, I’Allemand D, Gruters A. Thyroid function and obesity in children and adolescents. Horm Res 2000;54:14-9. doi:10.1159/000063431
5. Dekelbab BH, Abou Ouf HA, Jain I. Prevalence of elevated thyroid-stimulating hormone levels in obese children and adolescents. Endocr Pract 2010;16:187-90. doi: 10.4158/ EP09176.
6. Günöz H, Saner G, Demirkol M, Gökçay G, Hüner G, Garibağaoğlu M. Beslenme ve Beslenme Bozuklukları, “Pediatri” içinde Olcay Neyzi, Türkan Ertuğrul, editor. 3. Baskı, 1. Cilt. Ankara: Nobel Tıp Kitapevleri, 2002: 221-6.
7. Kapelari K, Kirchlechner C, Hogler W, et al. Pediatric reference intervals for thyroid hormone levels from birth to adulthood: a retrospective study. BMC Endocr Disord 2008;27:8-15. doi: 10.1186/1472-6823-8-15.
8. Radetti G, Kleon W, Buzi F, et al. Thyroid function and structure are affected in childhood obesity. J Clin Endocrinol Metab 2008;93:4749-54. doi: 10.1210/jc.2008-0823.
9. Grandone A, Santoro N, Coppola F, Calabrò P, Perrone L, Del Giudice EM. Thyroid function derangement and childhood obesity: an Italian experience. BMC Endocr Disord 2010;10:8. doi: 10.1186/1472-6823-10-8.
10. Bhowmick SK, Dasari G, Levens KL, Rettig KR. The prevalence of elevated serum thyroid stimulating hormone in childhood/adolescent obesity and of autoimmune thyroid diseases in a subgroup. J Nat Med Ass 2007;99:773-6. http:// www.ncbi.nlm.nih.gov/pmc/articles/PMC2574343/ Accessed on 11.082015
11. Mutlu RG, Özsu E, Çizmecioğlu FM. Şişman çocuklarda hafif TSH yüksekliği: Nasıl bir sorun? Türk Ped Arş 2011;46:33-6.
12. Kumar H, Verma A, Muthukrishnan J, et al. Obesity and thyrotropinemia. Indian J Pediatr 2009;76:933-5.
13. Knudsen N, Laurberg P, Rasmussen LB, Bülow I, Perrild H, Ovesen L, Jørgensen T. Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population. J. Clin Endocrinol Metab 2005;90:4019-24. doi: 10.1210/jc.2004-2225.
14. Marras V, Casini MR, Pilia S, et al. Thyroid function in obese children and adolescents. Horm Res Paediatr 2010;73:193-7. doi:10.1159/000284361
15. Reinehr T, Hinney A, de Sousa G, et al. Definable somatic disorders in overweight children and adolescents. J Pediatr 2007;150:618-22.
16. Lloyd RV, Jin L, Tsumanuma I, et al. Leptin and leptin receptor in anterior pituitary function. Pituitary 2001;4:33-47.
17. Ortiga-Carvalho TM, Oliveira KJ, Soares BA, et al. The role of leptin in the regulation of TSH secretion in the fed state: in vivo and in vitro studies, J Endocrinol. 2002;174:121-5. http://joe.endocrinology-journals.org/content/174/1/121.full. pdf Accessed on 11.08.2015
18. Fox S. C, Pencina MJ, D’Agostino RB, et al. Relations of thyroid function to body weight. Cross-sectional and longitudinal observations in a community-based sample. Arch Intern Med 2008;168:587-92. doi:10.1001/archinte.168.6.587.
19. Ross DS. Thyroid function and the metabolic syndrome. J Clin Endocrinol Metab 2007;92:491-6.
20. Reinehr T, De Sousa G, Andler W. Hyperthyrotropinemia in obese children is reversible after weight loss and is not related to lipids. J Clin Endocrinol Metab 2006;91:3088-91.
21. Holst-Schumacher I, Nuñez-Rivas H, Monge-Rojas R, Barrantes-Santamaría M. Components of the metabolic syndrome among a sample of overweight and obese Costa Rican schoolchildren. Food Nutr Bull 2009 ;30:161-70.
22. Pacifico L, Bonci E, Ferraro F, et al. Hepatic steatosis and thyroid function tests in overweight and obese children. International Journal of Endocrinology 2013:38:10-4. doi: 10.1155/2013/381014.
23. Aeberli I, Jung A, Murer SB, et al. During rapid weight loss in obese children, reductions in TSH predict improvements in insulin sensitivity independent of changes in body weight or fat. J Clin Endocrinol Metab 2010;95:5412-8. doi: 10.1210/ jc.2010-1169.
24. Eliakim A, Barzilai M, Wolach B, Nemet D. Should we treat elevated thyroid stimulating hormone levels in obese children and adolescents? Int J Pediatr Obes 2006;1:217-21.
25. Sari R, Balci MK, Altunbas H, et al. The effect of body weight and weight loss on thyroid volume and function in obese women. Clin Endocrinol 2003;59:258-62. doi: 10.1046/j.1365-2265.2003.01836.x.
26. Shalitin S, Yackobovitch-Gavan M, Phillip M. Prevalence of thyroid dysfunction in obese children and adolescents before and after weight reduction and its relation to other metabolic parameters. Horm Res 2009;71:155-61. doi: 10.1159/000197872.
27. Santos MI, Limbert C, Marques FC, Rosário F, Lopes L. Childhood obesity, thyroid function, and insulin resistance – is there a link? A longitudinal study.J Pediatr Endocrinol Metab. 2015 May;28(5-6):557-62. doi: 10.1515/jpem-2014-0319.
28. Lazar L, Frumkin RB, Battat E, Lebenthal Y, Phillip M, Meyerovitch J. Natural history of thyroid function tests over 5 years in a large pediatric cohort. J Clin Endocrinol Metab 2009;94:1678-82. doi: 10.1210/jc.2008-2615.
29. Kaptein EM, Beale E, Chan LS. Thyroid hormone therapy for obesity and nonthyroidal illnesses: a systematic review. J Clin Endocrinol Metab 2009;94:3663-75. doi: 10.1210/jc.2009- 0899

There are 29 citations in total.

Details

Primary Language	EN
Journal Section	Articles
Authors	Ferhat Ekinci This is me Arzu Uzuner Merder Demet This is me Bilge Turgut This is me Niyazi Tosun This is me
Publication Date	November 28, 2015
Published in Issue	Year 2015 Volume: 28 Issue: 3

Cite

APA	Ekinci, F., Uzuner, A., Demet, M., Turgut, B., et al. (2015). -. Marmara Medical Journal, 28(3), 129-134. https://doi.org/10.5472/MMJoa.2803.02
AMA	Ekinci F, Uzuner A, Demet M, Turgut B, Tosun N. -. Marmara Med J. December 2015;28(3):129-134. doi:10.5472/MMJoa.2803.02
Chicago	Ekinci, Ferhat, Arzu Uzuner, Merder Demet, Bilge Turgut, and Niyazi Tosun. “-”. Marmara Medical Journal 28, no. 3 (December 2015): 129-34. https://doi.org/10.5472/MMJoa.2803.02.
EndNote	Ekinci F, Uzuner A, Demet M, Turgut B, Tosun N (December 1, 2015) -. Marmara Medical Journal 28 3 129–134.
IEEE	F. Ekinci, A. Uzuner, M. Demet, B. Turgut, and N. Tosun, “-”, Marmara Med J, vol. 28, no. 3, pp. 129–134, 2015, doi: 10.5472/MMJoa.2803.02.
ISNAD	Ekinci, Ferhat et al. “-”. Marmara Medical Journal 28/3 (December 2015), 129-134. https://doi.org/10.5472/MMJoa.2803.02.
JAMA	Ekinci F, Uzuner A, Demet M, Turgut B, Tosun N. -. Marmara Med J. 2015;28:129–134.
MLA	Ekinci, Ferhat et al. “-”. Marmara Medical Journal, vol. 28, no. 3, 2015, pp. 129-34, doi:10.5472/MMJoa.2803.02.
Vancouver	Ekinci F, Uzuner A, Demet M, Turgut B, Tosun N. -. Marmara Med J. 2015;28(3):129-34.

Marmara Medical Journal

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Abstract

Keywords

References

Thyroid hormones and BMI in obese children: One year follow up results

Abstract

Keywords

References

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Cited By

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