Research Article
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Year 2024, Volume: 37 Issue: 3, 318 - 322, 30.10.2024
https://doi.org/10.5472/marumj.1571786

Abstract

References

  • Childress MA, Becker BA. Nonoperative management of cervical radiculopathy. Am Fam Physician 2016;93:746-54.
  • Mansfield M, Smith T, Spahr N, Thacker M. Cervical spine radiculopathy epidemiology: A systematic review. Musculoskeletal Care 2020;18:555-67. doi: 10.1002/msc.1498
  • Oh D, Cheong SH, Choi YG, Moon SH, Ko MJ. Predictive factors for favorable short-term response to interlaminar epidural block for cervical radiculopathy. J Anesth 2023;37:23-31. doi:10.1007/s00540.022.03122-y
  • Manchikanti L, Cash KA, Pampati V, Wargo WB, Malla Y. Management of chronic pain of cervical disc herniation and radiculitis with fluoroscopic cervical interlaminar epidural injections. Int J Med Sci 2012;9:424-34. doi: 10.7150/ijms.4444
  • Celenlioglu AE, Solmaz I, Eksert S, Simsek F, Ilkbahar S, Sir E. Factors associated with treatment success after interlaminar epidural steroid injection for cervical radicular pain. Turk Neurosurg 2023;33:326-33. doi: 10.5137/1019-5149.Jtn.42539- 22.2
  • Sacaklidir R, Sanal-Toprak C, Yucel FN, Gunduz OH, Sencan H. The effect of central sensitization on interlaminar epidural steroid injection treatment outcomes in patients with cervical disc herniation: An observational study. Pain Physician 2022;25:E823-e9.
  • Helde-Frankling M, Björkhem-Bergman L. Vitamin D in pain management. Int J Mol Sci 2017;18:2170. doi: 10.3390/ ijms18102170.
  • Eloqayli H, Al-Yousef A, Jaradat R. Vitamin D and ferritin correlation with chronic neck pain using standard statistics and a novel artificial neural network prediction model. Br J Neurosurg 2018;32:172 – 6.
  • Liu X, Nelson A, Wang X, et al. Vitamin D modulates prostaglandin e2 synthesis and degradation in human lung fibroblasts. Am J Respir Cell Mol Biol 2014;50:40-50. doi: 10.1165/rcmb.2013-0211OC
  • Wepner F, Scheuer R, Schuetz-Wieser B, et al. Effects of vitamin d on patients with fibromyalgia syndrome: A randomized placebo-controlled trial. Pain 2014;155:261-8. doi: 10.1016/j. pain.2013.10.002
  • Ozturk EC, Sencan S, Sacaklidir R, Albayrak O, Gunduz OH. The impact of vitamin D deficiency to treatment success of transforaminal epidural steroid injection. Pain Physician 2021;24:E619-e24.
  • Gifondorwa DJ, Thompson TD, Wiley J, et al. Vitamin D and/ or calcium deficient diets may differentially affect muscle fiber neuromuscular junction innervation. Muscle Nerve 2016;54:1120-32. doi: 10.1002/mus.25146
  • Maser RE, Lenhard MJ, Pohlig RT. Vitamin d insufficiency is associated with reduced parasympathetic nerve fiber function in type 2 diabetes. Endocr Pract 2015;21:174-81. doi: 10.4158/ ep14332.Or
  • Karras S, Rapti E, Matsoukas S, Kotsa K. Vitamin d in fibromyalgia: A causative or confounding biological interplay? Nutrients 2016;8:343. doi: 10.3390/nu8060343
  • Hewison M. Vitamin D and immune function: An overview. Proc Nutr Soc 2012;71:50-61. doi: 10.1017/ s002.966.5111001650
  • Gendelman O, Itzhaki D, Makarov S, Bennun M, Amital H. A randomized double-blind placebo-controlled study adding high dose vitamin d to analgesic regimens in patients with musculoskeletal pain. Lupus 2015;24:483-9. doi: 10.1177/096.120.3314558676
  • Qin W, Smith C, Jensen M, Holick MF, Sauter ER. Vitamin d favorably alters the cancer promoting prostaglandin cascade. Anticancer Res 2013;33:3861-6.
  • Stoker GE, Buchowski JM, Chen CT, Kim HJ, Park MS, Riew KD. Hypovitaminosis d and cervical disk herniation among adults undergoing spine surgery. Global Spine J 2013;3:231-6. doi: 10.1055/s 0033.135.4252
  • Sencan S, Edipoglu IS, Yazici G, Yucel FN, Gunduz OH. Are foraminal stenosis severity and herniation level associated with the treatment success of cervical interlaminar epidural steroid injection? Pain Physician 2020;23:325-32.
  • Sanal-Toprak C, Ozturk EC, Yucel FN, Sencan S, Gunduz OH. Does the presence of neuropathic pain affect the outcomes of the interlaminar epidural steroid injection for cervical disc herniation?: A prospective clinical study. Medicine (Baltimore) 2021;100:e25012. doi: 10.1097/md.000.000.0000025012
  • Basit A, Basit KA, Fawwad A, et al. Vitamin d for the treatment of painful diabetic neuropathy. BMJ Open Diabetes Res Care 2016;4:e000148. doi: 10.1136/bmjdrc-2015-000148

The impact of vitamin D deficiency on treatment success of cervical interlaminar epidural steroid injection

Year 2024, Volume: 37 Issue: 3, 318 - 322, 30.10.2024
https://doi.org/10.5472/marumj.1571786

Abstract

ABSTRACT
Objective: Our aim is to investigate the effect of vitamin D deficiency on treatment success of cervical interlaminar epidural steroid
injection (ILESI) in patients with cervical disc herniation-related chronic radiculopathy.
Patients and Methods: Fifty patients who had neck and unilateral extremity pain and received cervical ILESI were included. The
patients were divided into two groups according to their serum 25 (OH) D levels as Group 1 (>20 ng/mL) and Group 2 (<20 ng/
mL). Clinical and demographic data, magnetic resonance imaging (MRI) scans, pre-procedural laboratory tests, and pain scores were
recorded. The patients were assessed before procedure and at three and six months after procedure.
Results: Mean serum 25(OH)D level was 29.49±10.9 in Group 1 and 12.06±3.49 in Group 2, indicating a statistically significant
difference (p<0.001). A significant improvement in pain scores was observed in both groups at six months of follow-up (p<0.001).
Treatment success rates were significantly lower in vitamin D-deficient group at three months (p=0.024), while there was no significant
difference between the groups at six months.
Conclusions: Vitamin D level is a factor affecting short-term treatment success in patients undergoing cervical ILESI.

References

  • Childress MA, Becker BA. Nonoperative management of cervical radiculopathy. Am Fam Physician 2016;93:746-54.
  • Mansfield M, Smith T, Spahr N, Thacker M. Cervical spine radiculopathy epidemiology: A systematic review. Musculoskeletal Care 2020;18:555-67. doi: 10.1002/msc.1498
  • Oh D, Cheong SH, Choi YG, Moon SH, Ko MJ. Predictive factors for favorable short-term response to interlaminar epidural block for cervical radiculopathy. J Anesth 2023;37:23-31. doi:10.1007/s00540.022.03122-y
  • Manchikanti L, Cash KA, Pampati V, Wargo WB, Malla Y. Management of chronic pain of cervical disc herniation and radiculitis with fluoroscopic cervical interlaminar epidural injections. Int J Med Sci 2012;9:424-34. doi: 10.7150/ijms.4444
  • Celenlioglu AE, Solmaz I, Eksert S, Simsek F, Ilkbahar S, Sir E. Factors associated with treatment success after interlaminar epidural steroid injection for cervical radicular pain. Turk Neurosurg 2023;33:326-33. doi: 10.5137/1019-5149.Jtn.42539- 22.2
  • Sacaklidir R, Sanal-Toprak C, Yucel FN, Gunduz OH, Sencan H. The effect of central sensitization on interlaminar epidural steroid injection treatment outcomes in patients with cervical disc herniation: An observational study. Pain Physician 2022;25:E823-e9.
  • Helde-Frankling M, Björkhem-Bergman L. Vitamin D in pain management. Int J Mol Sci 2017;18:2170. doi: 10.3390/ ijms18102170.
  • Eloqayli H, Al-Yousef A, Jaradat R. Vitamin D and ferritin correlation with chronic neck pain using standard statistics and a novel artificial neural network prediction model. Br J Neurosurg 2018;32:172 – 6.
  • Liu X, Nelson A, Wang X, et al. Vitamin D modulates prostaglandin e2 synthesis and degradation in human lung fibroblasts. Am J Respir Cell Mol Biol 2014;50:40-50. doi: 10.1165/rcmb.2013-0211OC
  • Wepner F, Scheuer R, Schuetz-Wieser B, et al. Effects of vitamin d on patients with fibromyalgia syndrome: A randomized placebo-controlled trial. Pain 2014;155:261-8. doi: 10.1016/j. pain.2013.10.002
  • Ozturk EC, Sencan S, Sacaklidir R, Albayrak O, Gunduz OH. The impact of vitamin D deficiency to treatment success of transforaminal epidural steroid injection. Pain Physician 2021;24:E619-e24.
  • Gifondorwa DJ, Thompson TD, Wiley J, et al. Vitamin D and/ or calcium deficient diets may differentially affect muscle fiber neuromuscular junction innervation. Muscle Nerve 2016;54:1120-32. doi: 10.1002/mus.25146
  • Maser RE, Lenhard MJ, Pohlig RT. Vitamin d insufficiency is associated with reduced parasympathetic nerve fiber function in type 2 diabetes. Endocr Pract 2015;21:174-81. doi: 10.4158/ ep14332.Or
  • Karras S, Rapti E, Matsoukas S, Kotsa K. Vitamin d in fibromyalgia: A causative or confounding biological interplay? Nutrients 2016;8:343. doi: 10.3390/nu8060343
  • Hewison M. Vitamin D and immune function: An overview. Proc Nutr Soc 2012;71:50-61. doi: 10.1017/ s002.966.5111001650
  • Gendelman O, Itzhaki D, Makarov S, Bennun M, Amital H. A randomized double-blind placebo-controlled study adding high dose vitamin d to analgesic regimens in patients with musculoskeletal pain. Lupus 2015;24:483-9. doi: 10.1177/096.120.3314558676
  • Qin W, Smith C, Jensen M, Holick MF, Sauter ER. Vitamin d favorably alters the cancer promoting prostaglandin cascade. Anticancer Res 2013;33:3861-6.
  • Stoker GE, Buchowski JM, Chen CT, Kim HJ, Park MS, Riew KD. Hypovitaminosis d and cervical disk herniation among adults undergoing spine surgery. Global Spine J 2013;3:231-6. doi: 10.1055/s 0033.135.4252
  • Sencan S, Edipoglu IS, Yazici G, Yucel FN, Gunduz OH. Are foraminal stenosis severity and herniation level associated with the treatment success of cervical interlaminar epidural steroid injection? Pain Physician 2020;23:325-32.
  • Sanal-Toprak C, Ozturk EC, Yucel FN, Sencan S, Gunduz OH. Does the presence of neuropathic pain affect the outcomes of the interlaminar epidural steroid injection for cervical disc herniation?: A prospective clinical study. Medicine (Baltimore) 2021;100:e25012. doi: 10.1097/md.000.000.0000025012
  • Basit A, Basit KA, Fawwad A, et al. Vitamin d for the treatment of painful diabetic neuropathy. BMJ Open Diabetes Res Care 2016;4:e000148. doi: 10.1136/bmjdrc-2015-000148
There are 21 citations in total.

Details

Primary Language English
Subjects Surgery (Other)
Journal Section Original Research
Authors

Savaş Şencan 0000-0001-8150-0581

Rekib Sacaklidir

Asya Ozen Dogan 0009-0003-4051-0996

Oguzhan Akgunoglu This is me 0009-0001-7066-6284

Bahadir Dokumaci 0009-0003-4958-9143

Mustafa Alsadah This is me 0000-0003-4587-6404

Osman Hakan Gündüz 0000-0002-3214-803X

Publication Date October 30, 2024
Submission Date November 7, 2023
Acceptance Date January 16, 2024
Published in Issue Year 2024 Volume: 37 Issue: 3

Cite

APA Şencan, S., Sacaklidir, R., Ozen Dogan, A., Akgunoglu, O., et al. (2024). The impact of vitamin D deficiency on treatment success of cervical interlaminar epidural steroid injection. Marmara Medical Journal, 37(3), 318-322. https://doi.org/10.5472/marumj.1571786
AMA Şencan S, Sacaklidir R, Ozen Dogan A, Akgunoglu O, Dokumaci B, Alsadah M, Gündüz OH. The impact of vitamin D deficiency on treatment success of cervical interlaminar epidural steroid injection. Marmara Med J. October 2024;37(3):318-322. doi:10.5472/marumj.1571786
Chicago Şencan, Savaş, Rekib Sacaklidir, Asya Ozen Dogan, Oguzhan Akgunoglu, Bahadir Dokumaci, Mustafa Alsadah, and Osman Hakan Gündüz. “The Impact of Vitamin D Deficiency on Treatment Success of Cervical Interlaminar Epidural Steroid Injection”. Marmara Medical Journal 37, no. 3 (October 2024): 318-22. https://doi.org/10.5472/marumj.1571786.
EndNote Şencan S, Sacaklidir R, Ozen Dogan A, Akgunoglu O, Dokumaci B, Alsadah M, Gündüz OH (October 1, 2024) The impact of vitamin D deficiency on treatment success of cervical interlaminar epidural steroid injection. Marmara Medical Journal 37 3 318–322.
IEEE S. Şencan, R. Sacaklidir, A. Ozen Dogan, O. Akgunoglu, B. Dokumaci, M. Alsadah, and O. H. Gündüz, “The impact of vitamin D deficiency on treatment success of cervical interlaminar epidural steroid injection”, Marmara Med J, vol. 37, no. 3, pp. 318–322, 2024, doi: 10.5472/marumj.1571786.
ISNAD Şencan, Savaş et al. “The Impact of Vitamin D Deficiency on Treatment Success of Cervical Interlaminar Epidural Steroid Injection”. Marmara Medical Journal 37/3 (October 2024), 318-322. https://doi.org/10.5472/marumj.1571786.
JAMA Şencan S, Sacaklidir R, Ozen Dogan A, Akgunoglu O, Dokumaci B, Alsadah M, Gündüz OH. The impact of vitamin D deficiency on treatment success of cervical interlaminar epidural steroid injection. Marmara Med J. 2024;37:318–322.
MLA Şencan, Savaş et al. “The Impact of Vitamin D Deficiency on Treatment Success of Cervical Interlaminar Epidural Steroid Injection”. Marmara Medical Journal, vol. 37, no. 3, 2024, pp. 318-22, doi:10.5472/marumj.1571786.
Vancouver Şencan S, Sacaklidir R, Ozen Dogan A, Akgunoglu O, Dokumaci B, Alsadah M, Gündüz OH. The impact of vitamin D deficiency on treatment success of cervical interlaminar epidural steroid injection. Marmara Med J. 2024;37(3):318-22.