Is aortic elasticity associated with hydration status in stage of chronic renal disease in children?

Year 2024, Volume: 37 Issue: 3, 311 - 317, 30.10.2024

Özlem Sarısoy , Şule Arıcı Ece Demirci Bodur , Oguzhan Tezel Harika Alpay , Figen Akalın

https://doi.org/10.5472/marumj.1573657

Abstract

Objective: We aimed to evaluate cardiovascular risks and influencing factors by measuring aortic elasticity parameters and carotid
intima thickness in children with cronic kidney disease (CKD), and also evaluated the hydration status of patients with bioimpedance
spectroscopy (BIS) measurements and investigated the effect of hydration status on vascular functions.
Patients and Methods: The study group included an average of 13.3 ± 3.7 years (16 girls and 22 boys, 38 CKD patients), control group
on average 12.1 ± 2.9 (16 girls and 15 boys, 31 healthy children). Systolic and diastolic diameters of the aortic annulus and aorta at each
level were obtained; z-scores, aortic strain, distensibility, stiffness index were calculated. Carotid intima-media thickness and flow –
mediated dilatation were studied. Bioimpedance spectroscopy was performed to all patients.
Results: Interventricular septum and left atrial (p=0.002, p=0.013), sinus valsalva and sinotubular junction z scores (p=0.009, p=0.012)
were found to be higher and distensibility and strain decreased, stiffness index increased in the abdominal aorta of patients with CKD
(p=0.007, p=0.002, p=0.004). Patients with CKD had statistically significant over-hydration.
Conclusion: Vascular wall changes that affect the elastic properties of the aortic wall begin to develop in childhood in patients with
CKD.

Keywords

Chronic kidney disease, Aortic elasticity, Bioimpedance spectroscopy

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