Outcome of Ewing sarcoma in children: Twenty years experience from a single center

Year 2024, Volume: 37 Issue: 3, 373 - 378, 30.10.2024

Nurşah Eker , Gizem Tanali Ömer Sofulu , Zerrin Ozgen Kemal Turkoz Ayse Gulnur Tokuc

https://doi.org/10.5472/marumj.1573692

Abstract

ABSTRACT
Objective: Ewing sarcoma (ES) is a significant malignancy in pediatric patients, with a notable impact on bone health. Despite advances
in treatment, ES still poses challenges, particularly in cases of metastasis or relapse. This study aims to evaluate the outcomes of ES in
children treated at our center over a twenty-year period.
Patients and Methods: We retrospectively reviewed pediatric patients diagnosed with ES at our center between January 2004 and
February 2024. Data including demographic information, tumor characteristics, treatment modalities, and survival outcomes were
analyzed.
Results: Among 986 pediatric solid tumor cases, 137 (13.8%) were diagnosed with ES. After excluding ineligible cases, 115 ES cases
were included in the study. The most common sites of involvement were the lower extremities. Metastatic disease was observed
in 35.8% of cases, with the lungs being the most common site. Advanced age, and pelvic involvement were associated with poor
prognosis. Histopathological response to neoadjuvant chemotherapy, represented by tumor necrosis rate, metastatic and relapse
disease significantly influenced survival outcomes.
Conclusion: Despite multimodal therapies, ES in children, especially with metastatic disease or relapse, presents a challenging
prognosis. Early diagnosis and the development of novel treatment strategies are imperative to improve outcomes for these patients.

Keywords

Ewing sarcoma, Children, Survival, Prognosis

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