Determination of side effects and medication adherence in major depression patients utilized antidepressants

Year 2017, Volume: 21 Issue: 1, 177 - 182, 20.09.2016

Mesut Sancar , Emine Düzgün Betül Okuyan , Semanur Deniz Mecit Çalışkan Kadir Coşkun Fikret Vehbi İzzettin

https://doi.org/10.12991/marupj.259895

Abstract

The aim of the study is to
determine side effects, and medication  adherence
in patients who were diagnosed with major 
depression utilized antidepressants. This study was conducted  in outpatient psychiatry clinic between February
2013 and May  2013. ‘Toronto Side Effects
Scale’ and 4-item Morisky-Green-  Levine
Medication Adherence Scale were evaluated. Fifty-six  major depression patients (mean of age: 40.82
± 14.28 years  old; male/female: 13/43)
were included in this study. Patients  were
treated with escitalopram (46.4%), sertraline (26.8%),  venlafaxine (10.7%), citalopram (8.9%) and
paroxetine (7.1%).  The most common side
effects that patients reported were  drowsiness/
daytime somnolence (57.1%), dry mouth (46.4%) 
and increased sleep (46.4%), increased appetite (37.5%) and  malaise or fatigue (30.4%). The most severity
side effects that  patients experienced
were drowsiness/ daytime somnolence  (25%),
increased sleep (19.6%) and decreased libido (14.3%).  Only fifteen (26.8%) patients were found high
adherent to their  medication. It was
concluded that although the frequency and 
severity of side effects have been found high, the percentage of  patients’ medication adherence has been
obtained low. Patient  education and
monitoring regarding side effects and medication  adherence providing by pharmacists would be
contributed to  prevent possible drug
induced problems in these patients besides 
the routine services they are taken from outpatient clinic.  

Keywords

Depression, Side Effects, Patient adherence

Antidepresan Kullanan Majör Depresyon Hastalarında Yan Etkilerin ve Hasta Uyuncunun Değerlendirilmesi

Abstract

Bu çalışmanın amacı, antidepresan
kullanan majör  depresyon hastalarında
yan etkilerin ve hasta uyuncunun  değerlendirilmesidir.
Çalışma Şubat-Mayıs 2013 tarihleri  arasında
bir psikiyatri polikliniğinde yürütülmüştür. Yan  etkilerin tespiti için “Toronto Yan Etki
Ölçeği”, tedaviye  uyuncun belirlenmesi
için ise “Morisky Green Levine Uyunç  Ölçeği”
kullanılmıştır. Çalışma 56 majör depresyon tanısı alan  hasta ile (yaş ortalaması: 40,82 ± 14,28;
erkek/kadın: 13/43)  tamamlanmıştır.
Hastalar depresyon tedavisi için essitalopram 
(% 46,4), sertralin (% 26,8), venlafaksin (% 10,7), sitalopram  (% 8,9) ve paroksetin (%7,1) kullanmaktaydı.
Hastaların en  yaygın bildirdiği yan
etkilerin sersemlik/gündüz uykuya eğilim 
(% 57,1), ağız kuruluğu (% 46,4), uykuda artış (% 46,4), iştah  artması (% 37,5) ve halsizlik veya yorgunluk
(% 30,4) olduğu  tespit edilmiştir.
Hastaların yaşadıkları bu yan etkiler şiddet 
derecesine göre değerlendirildiğinde ilk sıraları sersemlik/  gündüz uykuya eğilim (% 25,0), uykuda artış
(% 19,6) ve libido  azalması (% 14,3) yan
etkilerinin aldığı gözlenmiştir. Çalışmaya 
katılan hastaların sadece % 26,8’inin ilaçlarına uyunç oranlarının  yüksek olduğu saptanmıştır. Antidepresan
kullanan hastalarda  görülen yan etki
sıklığının ve şiddetinin yüksek olduğu ve 
ayrıca hastaların ilaç uyunç oranlarının düşük olduğu sonucuna  varılmıştır. Bu hastaların poliklinikten
aldıkları rutin hizmetin  yanısıra
eczacılar tarafından yan etkiler ve uyunç konusunda  eğitilmeleri ve izlenmeleri, ilaç kaynaklı
olası sorunların önüne  geçilmesine katkı
sağlayacaktır.  

Keywords

Depresyon, Yan Etkiler, Hasta uyumu

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