Comparison of Antibiotic Sensitivity Pattern of Escherichia coli which Produce Extended Spectrum Beta-Lactamase Strains Isolated From Various Clinical Specimens In Intensive Care Unit

Year 2019, Volume: 5 Issue: 1, 33 - 38, 28.04.2019

Tuğba Cebeci , Dilek Keskin , Ahmet Ali Gökal

https://doi.org/10.19127/mbsjohs.525833

Abstract

Objective: A retrospective
analysis of the widely
used antibiotics all
susceptibility testing results from Escherichia coli (E. coli) cultured
from clinical specimens private hospital (from January
2017 to November 2018) was performed.  

Methods: The VITEK 2 Compact automated
microbiology system (bioMérieux) is designed for automated rapid antimicrobial
susceptibility testing and identification of clinically relevant bacteria. Minimum
inhibitory concentration (MIC) results previously obtained in recent clinical
isolates with well-defined in isolates with well-characterized resistance
mechanisms with the microdilution method were re-interpreted for the
susceptible, intermediate and resistant categories using the 2018 EUCAST
breakpoints. Clinical
samples are
most commonly isolated from blood, sputum and urine samples.  

Results: The results of
resistance pattern of E. coli
isolates in our locality to antimicrobial agents showed that the 64 E. coli strains tested against fifteen
antimicrobial agents. E. coli
isolates were highly resistant to piperacillin, ceftazidime and aztreonam 98%,
61% and 61% respectively. The most sensitive antibiotics were colistin, tigecycline,
imipenem and meropenem. In the
present study, 73% (47) of the isolates were resistant to at least three to
fourteen antibiotics. All of the isolates showed resistance to at least one
antibiotics. Thirty nine per cent of E.
coli isolates were extended
spectrum beta-lactamase (ESBL) producers.  

Conclusion: Considering the antibiogram, imipenem and meropenem should be preferred drugs
for E. coli infection isolated from
clinical samples.

Keywords

Esherichia coli, antibiotic sensitivity, clinical specimens, intensive care unit

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