Association of Vitamin D, IL-6, TNF-α, CRP and Periodontal Health Status in the Eastern Black Sea Region

Year 2023, Volume: 9 Issue: 3, 498 - 510, 31.08.2023

Hatice Yemenoğlu , Meltem Zihni Korkmaz , Medeni Arpa

https://doi.org/10.19127/mbsjohs.1231689

Abstract

Objective: It is well established that vitamin D deficiency may increase risk of periodontitis, and that supplementation with vitamin D can contribute to maintain periodontal health. Since the Eastern Black Sea Region receives little sunlight due to its location, individuals living in this region don’t produce enough vitamin D and these individuals generally have vitamin D deficiency. The goal of this study was to analyze that association of vitamin D and periodontal health status in a study population of the Eastern Black Sea Region.
Methods: In this study, which was planned as a case control study, it was planned to reach a total of 72 samples, with at least 24 samples in each group in the sample calculation. As a result of data collection, 29 individuals with periodontitis, 28 individuals with gingivitis and 25 periodontally healthy individuals, a total of 82 individuals were included in the study. Cytokines in inflamed periodontal tissues have a marked effect on host modulation and onset and progression of periodontal disease. Venous blood samples were collected from the individuals. Periodontal clinical parameters were measured. Serum levels of 1.25(OH)2D3, 25(OH)D, C-reactive protein (CRP), tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) were assessed.
Results: Periodontally healthy group had statistically significantly lower periodontal clinical parameter values compared to gingivitis and periodontitis group (p<0.05). The serum 1.25(OH)2D3 level was lower in the periodontitis group compared to the periodontally healthy group and gingivitis group (p<0.05). But there was no statistically significant difference in the periodontitis 10.20 (3.70-29.50) ng/mL, gingivitis 11.35 (5.60-29.50) ng/mL and periodontally healthy groups 9.10 (2.90-55.40) ng/mL in terms of serum 25(OH)D levels (p>0.05).
Conclusion: The outcomes of this study support the idea that lower serum 1.25(OH)2D3 level has a negative effect on periodontal health status. Our data suggest that vitamin D supplementation to people living in the Eastern Black Sea Region would be beneficial in reducing the risk of developing periodontal disease. Further studies are needed on this subject.

Keywords

Cytokine, gingivitis, pathogenesis of periodontal disease, periodontitis, 1.25-hydroxyvitamin D

Project Number

2015.53002.111.07.01

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