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Usability of Saturation/Respiratory Rate as a Parameter In Pulmonary Thromboembolism Risk Scoring

Year 2025, Volume: 26 Issue: 1, 78 - 85, 20.03.2025
https://doi.org/10.69601/meandrosmdj.1594468

Abstract

Objective:The first step of pulmonary thromboembolism(PTE) treatment management is the risk classification.The most commonly used scoring system for this purpose is the pulmonary embolism severity index(PESI).However, the large number of parameters it contains limits its usability.For this reason, Therefore, the need for easily accessible, fast and accurate resulting parameters continues. This study was planned to evaluate the role of Saturation/Respiratory Rate (SPO2/RR) in determining the risk group.
Materials and Methods:This study was conducted retrospectively in patients diagnosed with PTE between XXX. Sociodemographic characteristics, vitals, laboratory results and radiological images of the patients were examined through the in-hospital information management system.
Results:188 patients were included in the study. The average age of the patients was 64.97 years. 107(56.9%) of the patients in the study were women.When patients were divided into groups according to early mortality risk, 35 patients(18.6%) were high risk; 31 patients(16.4%) intermediate-high risk;65 patients(34.5%) were in the intermediate-low risk group and 57 patients(30.5%) were in the low-risk group. SpO2/RR was found 3.29±0.82;3.97±0.60;4.50±0.92;5.00±0.77 respectively(p<0.001). It was determined that SpO2/RR was a guide in determining the risk group.
Conclusions: Saturation/respiratory rate can be used to determine risk groups in acute PTE and is also a guide in determining treatment management and mortality.

References

  • 1. Lehnert P, Lange T, Møller CH, Olsen PS, Carlsen J. Acute pulmonary embolism in a national Danish cohort: increasing incidence and decreasing mortality. Thromb Haemost. 2018;118(3):539-546.
  • 2. Aujesky D, Obrosky DS, Stone RA, Auble TE, Perrier A, Cornuz J et al. Derivation and validation of a prognostic model for pulmonary embolism. Am J Respir Crit Care Med. 2005;172(8):1041-6.
  • 3. Donadini MP, Dentali F, Castellaneta M, Gnerre P, La Regina M, Masotti L et al. Pulmonary embolism prognostic factors and length of hospital stay: a cohort study. Thromb Res. 2017; 156:155-9.
  • 4. Becattini C, Vedovati MC, Pruszczyk P, Vanni S, Cotugno M, Cimini LA et al. Oxygen saturation or respiratory rate to improve risk stratification in hemodynamically stable patients with acute pulmonary embolism. J Thromb Haemost. 2018;16(12):2397-402.
  • 5. Shen Y, Zhu L, Yan J. Stability of Spo2/Fio2 and respiratory rate-oxygenation indexes in critical respiratory disorders. Crit Care Med. 2022;50(8):e694-5.
  • 6. Fuentes YV, Carvajal K, Cardona S, Montaño GS, Ibáñez-Prada ED, Bastidas A et al. The respiratory rate-oxygenation index predicts failure of post-extubation high-flow nasal cannula therapy in intensive care unit patients: a retrospective cohort study. Rev Bras Ter Intensiva. 2022;34(3):360-6.
  • 7. Myers LC, Mark D, Ley B, Guarnieri M, Hofmeister M, Paulson S et al. Validation of respiratory rate-oxygenation index in patients with COVID-19-related respiratory failure. Crit Care Med. 2022;50(7):e638-42.
  • 8. Ageno W, Haas S, Weitz JI, Goldhaber SZ, Turpie AGG, Goto S et al. Characteristics and management of patients with venous thromboembolism: the GARFIELD-VTE registry. Thromb Haemost. 2019;119(2):319-27.
  • 9. Ozsu S, Ozlü T, Bülbül Y. Pulmonary thromboembolism based on the Turkish national data. Tuberk Toraks. 2009;57(4):466-82.
  • 10. Gök G, Karadağ M, Çinar T, Nurkalem Z, Duman D. In-hospital and short-term predictors of mortality in patients with intermediate-high risk pulmonary embolism. J Cardiovasc Thorac Res. 2020;12(4):321-7.
  • 11. Wang Y, Feng Y, Yang X, Mao H. Prognostic role of elevated lactate in acute pulmonary embolism: a systematic review and meta-analysis. Phlebology. 2022;37(5):338-47.
  • 12. Keller K, Beule J, Balzer JO, Dippold W. D-Dimer and thrombus burden in acute pulmonary embolism. Am J Emerg Med. 2018;36(9):1613-8.
  • 13. Chen YL, Wright C, Pietropaoli AP, Elbadawi A, Delehanty J, Barrus B et al. Right ventricular dysfunction is superior and sufficient for risk stratification by a pulmonary embolism response team. J Thromb Thrombolysis. 2020;49(1):34-41.
  • 14. Burrowes KS, Clark AR, Tawhai MH. Blood flow redistribution and ventilation-perfusion mismatch during embolic pulmonary arterial occlusion. Pulm Circ. 2011;1(3):365-76.
  • 15. Konstantinides SV, Meyer G, Becattini C, Bueno H, Geersing GJ, Harjola VP et al. 2019 ESC guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J. 2020;41(4):543-603.
  • 16. Jenab Y, Hosseini K, Esmaeili Z, Tofighi S, Ariannejad H, Sotoudeh H. Prediction of in-hospital adverse clinical outcomes in patients with pulmonary thromboembolism, machine learning-based models. Front Cardiovasc Med. 2023;10:1087702.
  • 17. Roca O, Caralt B, Messika J, Samper M, Sztrymf B, Hernández G et al. An index combining respiratory rate and oxygenation to predict outcome of nasal high-flow therapy. Am J Respir Crit Care Med. 2019;199(11):1368-76.
  • 18. Jolobe OMP. Importance of accurate respiratory rate for triage of suspected pulmonary embolism. QJM. 2020;113(2):143.
  • 19. Vedovati MC, Cimini LA, Pierpaoli L, Vanni S, Cotugno M, Pruszczyk P et al. Prognostic value of respiratory index in haemodynamically stable patients with acute pulmonary embolism: the respiratory index model study. Eur Heart J Acute Cardiovasc Care. 2020;9(4):286-92.

Pulmoner Tromboembolizm Risk Skorlamasinda Saturasyon/Solunum Hizi Oraninin Bir Parametre Olarak Kullanilabilirliği

Year 2025, Volume: 26 Issue: 1, 78 - 85, 20.03.2025
https://doi.org/10.69601/meandrosmdj.1594468

Abstract

Amaç: Pulmoner tromboembolizm (PTE) tedavi yönetiminde ilk adım risk sınıflamasıdır. Bu amaçla en yaygın kullanılan skorlama sistemi Pulmoner Emboli Şiddet İndeksi (PESI)'dir. Ancak, içerdiği parametrelerin fazlalığı, kullanımını sınırlamaktadır. Bu nedenle, kolay erişilebilir, hızlı ve doğru sonuç veren parametrelere ihtiyaç devam etmektedir. Bu çalışma, risk grubunun belirlenmesinde Saturasyon/Solunum sayısı (SpO2/SS)'nın rolünü değerlendirmek amacıyla planlanmıştır.
Materyal ve Metot: Bu çalışma, PTE tanısı almış hastalarda retrospektif olarak yürütülmüştür. Hastaların sosyodemografik özellikleri, vital bulguları, laboratuvar sonuçları ve radyolojik görüntüleri hastane bilgi yönetim sistemi üzerinden incelenmiştir.
Bulgular: Çalışmaya toplam 188 hasta dahil edilmiştir. Hastaların yaş ortalaması 64,97 yıl olarak bulunmuştur. Çalışmadaki hastaların 107’si (%56,9) kadın idi. Hastalar erken mortalite riskine göre gruplara ayrıldığında, 35 hasta (%18,6) yüksek risk; 31 hasta (%16,4) orta-yüksek risk; 65 hasta (%34,5) orta-düşük risk; 57 hasta (%30,5) düşük risk grubunda yer aldı. SpO2/RR sırasıyla 3,29±0,82; 3,97±0,60; 4,50±0,92; 5,00±0,77 olarak bulundu (p<0,001). SpO2/SS'nin risk grubunun belirlenmesinde yol gösterici olduğu tespit edildi.
Sonuç: Saturasyon/solunum sayısı oranı, akut PTE’de risk gruplarının belirlenmesinde kullanılabilir ve tedavi yönetimi ile mortalitenin belirlenmesinde yol gösterici bir parametredir.

References

  • 1. Lehnert P, Lange T, Møller CH, Olsen PS, Carlsen J. Acute pulmonary embolism in a national Danish cohort: increasing incidence and decreasing mortality. Thromb Haemost. 2018;118(3):539-546.
  • 2. Aujesky D, Obrosky DS, Stone RA, Auble TE, Perrier A, Cornuz J et al. Derivation and validation of a prognostic model for pulmonary embolism. Am J Respir Crit Care Med. 2005;172(8):1041-6.
  • 3. Donadini MP, Dentali F, Castellaneta M, Gnerre P, La Regina M, Masotti L et al. Pulmonary embolism prognostic factors and length of hospital stay: a cohort study. Thromb Res. 2017; 156:155-9.
  • 4. Becattini C, Vedovati MC, Pruszczyk P, Vanni S, Cotugno M, Cimini LA et al. Oxygen saturation or respiratory rate to improve risk stratification in hemodynamically stable patients with acute pulmonary embolism. J Thromb Haemost. 2018;16(12):2397-402.
  • 5. Shen Y, Zhu L, Yan J. Stability of Spo2/Fio2 and respiratory rate-oxygenation indexes in critical respiratory disorders. Crit Care Med. 2022;50(8):e694-5.
  • 6. Fuentes YV, Carvajal K, Cardona S, Montaño GS, Ibáñez-Prada ED, Bastidas A et al. The respiratory rate-oxygenation index predicts failure of post-extubation high-flow nasal cannula therapy in intensive care unit patients: a retrospective cohort study. Rev Bras Ter Intensiva. 2022;34(3):360-6.
  • 7. Myers LC, Mark D, Ley B, Guarnieri M, Hofmeister M, Paulson S et al. Validation of respiratory rate-oxygenation index in patients with COVID-19-related respiratory failure. Crit Care Med. 2022;50(7):e638-42.
  • 8. Ageno W, Haas S, Weitz JI, Goldhaber SZ, Turpie AGG, Goto S et al. Characteristics and management of patients with venous thromboembolism: the GARFIELD-VTE registry. Thromb Haemost. 2019;119(2):319-27.
  • 9. Ozsu S, Ozlü T, Bülbül Y. Pulmonary thromboembolism based on the Turkish national data. Tuberk Toraks. 2009;57(4):466-82.
  • 10. Gök G, Karadağ M, Çinar T, Nurkalem Z, Duman D. In-hospital and short-term predictors of mortality in patients with intermediate-high risk pulmonary embolism. J Cardiovasc Thorac Res. 2020;12(4):321-7.
  • 11. Wang Y, Feng Y, Yang X, Mao H. Prognostic role of elevated lactate in acute pulmonary embolism: a systematic review and meta-analysis. Phlebology. 2022;37(5):338-47.
  • 12. Keller K, Beule J, Balzer JO, Dippold W. D-Dimer and thrombus burden in acute pulmonary embolism. Am J Emerg Med. 2018;36(9):1613-8.
  • 13. Chen YL, Wright C, Pietropaoli AP, Elbadawi A, Delehanty J, Barrus B et al. Right ventricular dysfunction is superior and sufficient for risk stratification by a pulmonary embolism response team. J Thromb Thrombolysis. 2020;49(1):34-41.
  • 14. Burrowes KS, Clark AR, Tawhai MH. Blood flow redistribution and ventilation-perfusion mismatch during embolic pulmonary arterial occlusion. Pulm Circ. 2011;1(3):365-76.
  • 15. Konstantinides SV, Meyer G, Becattini C, Bueno H, Geersing GJ, Harjola VP et al. 2019 ESC guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J. 2020;41(4):543-603.
  • 16. Jenab Y, Hosseini K, Esmaeili Z, Tofighi S, Ariannejad H, Sotoudeh H. Prediction of in-hospital adverse clinical outcomes in patients with pulmonary thromboembolism, machine learning-based models. Front Cardiovasc Med. 2023;10:1087702.
  • 17. Roca O, Caralt B, Messika J, Samper M, Sztrymf B, Hernández G et al. An index combining respiratory rate and oxygenation to predict outcome of nasal high-flow therapy. Am J Respir Crit Care Med. 2019;199(11):1368-76.
  • 18. Jolobe OMP. Importance of accurate respiratory rate for triage of suspected pulmonary embolism. QJM. 2020;113(2):143.
  • 19. Vedovati MC, Cimini LA, Pierpaoli L, Vanni S, Cotugno M, Pruszczyk P et al. Prognostic value of respiratory index in haemodynamically stable patients with acute pulmonary embolism: the respiratory index model study. Eur Heart J Acute Cardiovasc Care. 2020;9(4):286-92.
There are 19 citations in total.

Details

Primary Language English
Subjects Emergency Medicine, Chest Diseases
Journal Section Research Article
Authors

Maşide Arı 0000-0002-5078-3176

Eren Usul 0000-0003-3980-6768

Emrah Arı 0000-0003-4006-380X

Fatma Yıldırım 0000-0003-3715-3097

Ali Türker Çiftçi 0000-0002-0227-5273

Ömer Faruk Tüten 0009-0001-5908-4670

Publication Date March 20, 2025
Submission Date December 1, 2024
Acceptance Date February 17, 2025
Published in Issue Year 2025 Volume: 26 Issue: 1

Cite

EndNote Arı M, Usul E, Arı E, Yıldırım F, Çiftçi AT, Tüten ÖF (March 1, 2025) Usability of Saturation/Respiratory Rate as a Parameter In Pulmonary Thromboembolism Risk Scoring. Meandros Medical And Dental Journal 26 1 78–85.