Research Article
BibTex RIS Cite

Frontal QRS-T Açısı İle Ambulatuar 24 Saat Holterde Prematür Ventriküler Kontraksiyon Yükü Arasındaki İlişki

Year 2022, , 200 - 206, 20.08.2022
https://doi.org/10.30565/medalanya.1131541

Abstract

Amaç: Sık prematür ventriküler kontraksiyonlar (PVK), ventriküler fonksiyonun bozulmasına veya ventriküler kavitelerin genişlemesine neden olabilir. Frontal düzlem QRS-T [f(QRS-T)] açısı, miyokardın elektrofizyolojik özelliklerindeki kararsızlığın bir göstergesidir ve aritmilerle ilişkilidir. Bu çalışma, ventriküler repolarizasyon heterojenitesinin bir belirteci olarak f(QRS-T) açısının, ambulatuar 24 saatlik holterde prematüre ventriküler kasılma yükünü tahmin edip etmediğini araştırmayı amaçlamıştır.

Yöntem: Çalışmada 100 hasta mevcuttu. Hastalar 24 saatlik Holter izleminde PVK yüklerine göre “sık PVK” ve “nadir PVK” olarak iki gruba ayrıldı. Laboratuar ve frontal plan QRS-T açısı dahil olmak üzere bazı ambulatuar elektrokardiyografi parametreleri iki grup arasında karşılaştırıldı.

Bulgular: Frontal QRS-T açısı (63.34±37.86°’ye karşı 23.46±14.29° p<0.001) Sık PVK grubunda daha geniş bulundu. F(QRS-T) açısının ≥ 34° olması; PVK yükünü göstermede %82.2 duyarlılığa ve %80 özgüllüğe sahipti (AUC: 0.887 (0.824-0.950). Ayrıca PVK yükü ile f(QRS-T) açısı arasında pozitif korelasyon bulundu (r:0.429 p<0.001).

Sonuç: F(QRS-T) açısının genişlemesi, 24 saatlik Holter izleminde artmış PVK yükünün bir göstergesi olarak düşünülebilir. 12 derivasyonlu EKG'de PVK’sı olan hastalarda f(QRS-T) açısının ölçülmesi, artmış PVK yükü için uyarıcı bir bulgu olabilir.

References

  • 1. Saurav A, Smer A, Abuzaid A, Bansal O, Abuissa H. Premature Ventricular Contraction Induced Cardiomyopathy. Clin. Cardiol. 2015; 38, 4, 251–58 DOI: 10.1002/clc.22371
  • 2. Kennedy HL, Whitlock JA, Sprague MK, Kennedy LJ, Buckingham TA, Goldberg RJ. Longterm follow-up of asymptomatic healthy subjects with frequent and complex ventricular ectopy. N Engl J Med 1985;312:193–97. DOI: 10.1056/NEJM198501243120401
  • 3. Dukes JW, Dewland TA, Vittinghoff E, Mandyam MC , Heckbert SR , Siscovick DS et al. Ventricular ectopy as a predictor of heart failure and death. J. Am. Coll. Cardiol. 2015; 66(2), 101–09 DOI: 10.1016/j.jacc.2015.04.062
  • 4. Shvilkin A, Anter E. Cardiomyopathy-inducing premature ventricular contractions: not all animals are equal? Heart Rhythm 2012;9(9),1473–74. DOI: 10.1016/j.hrthm.2012.06.027
  • 5. Latchamsetty R, Bogun F. Premature ventricular complex induced cardiomyopathy. Rev. Esp. Cardiol. (Engl. Ed.). 2016;69(4), 365–369 DOI: 10.1016/j.rec.2015.12.015
  • 6. Lin C-Y, Chang S-L, Lin Y-J, Lo Li-W , Chung F-P, Chen Y-Y et al. Long-term outcome of multiform premature ventricular complexes in structurally normal heart. International Journal of Cardiology 2015;180:80-85. DOI: 10.1016/j.ijcard.2014.11.110.
  • 7. Ruberman W, Weinblatt E, Goldberg JD, Frank C W, Chaudhary B S, Shapiro S et al. Ventricular premature complexes and sudden death after myocardial infarction. Circulation 1981; 64(2): 297-305. DOI: 10.1161/01.cir.64.2.297
  • 8. Macfarlane PW. The frontal plane QRS-T angle. Europace. 2012;14(6):773–75. DOI: 10.1093/europace/eus057
  • 9. Oehler A, Feldman T, Henrikson CA, Tereshchenko LG. QRS-T angle: a review. Ann Noninvasive Electrocardiol. 2014;19(6):534–42. DOI: 10.1111/anec.12206
  • 10. Aro AL, Huikuri HV, Tikkanen JT, Junttila MJ, Rissanen HA, Reunanenet A al. QRS-T angle as a predictor of sudden cardiac death in a middle-aged general population. Europace. 2012;14(6):872–76. DOI: 10.1093/europace/eur393
  • 11. Raposeiras-Roubin S, Virgos-Lamela A, Bouzas-Cruz N, López-López A , Castiñeira-Busto M, Fernández-Garda R et al. Usefulness of the QRS-T angle to improve long-term risk stratification of patients with acute myocardial infarction and depressed left ventricular ejection fraction. Am J Cardiol. 2014; 113(8):1312–1319. DOI: 10.1016/j.amjcard.2014.01.406
  • 12. Jogu HR, O'Neal WT, Broughton ST, Shah AJ, Zhang Z-M, Solimanet EZ al. Frontal QRS-T angle and the risk of atrial fibrillation in the elderly. Ann Noninvasive Electrocardiol. 2017;22(2):e12388. DOI: 10.1111/anec.12388
  • 13. Lazzeroni D, Bini M, Camaiora U, Castiglioni P, Moderato L, Ugolotti TP et al. Prognostic value of frontal QRS-T angle in patients undergoing myocardial revascularization or cardiac valve surgery. J Electrocardiol. 2018;51(6):967-972. DOI: 10.1016/j.jelectrocard.2018.08.028
  • 14. Baman TS, Lange DC, Ilg KJ, Gupta SK, Liu TY, Alguire C et al. Relationship between burden of premature ventricular complexes and left ventricular function. Heart Rhythm 2010;7(7):865-9. DOI: 10.1016/j.hrthm.2010.03.036
  • 15. Zhang ZM, Rautaharju PM, Prineas RJ, Tereshchenko L, Soliman EZ. Electrocardiographic QRS-T angle and the risk of incident silent myocardial infarction in the Atherosclerosis Risk in Communities study. J Electrocardiol. 2017;50(5):661–666. DOI: 10.1016/j.jelectrocard.2017.05.001
  • 16. Massing MW, Simpson RJ Jr, Rautaharju PM, Schreiner P J, Crow R, Heiss G. Usefulness of ventricular premature complexes to predict coronary heart disease events and mortality (from the Atherosclerosis Risk in Communities Cohort). Am J Cardiol 2006;98:1609e12. DOI: 10.1016/j.amjcard.2006.06.061
  • 17. Agarwal SK, Simpson RJ Jr, Rautaharju P, Alonso A, , Shahar EC, Massing M et al. Relation of ventricular premature complexes to heart failure (from the Atherosclerosis Risk In Communities [ARIC] study). Am. J. Cardiol. 2012;109(1), 105–109. DOI: 10.1016/j.amjcard.2011.08.009
  • 18. Glancy JM, Weston PJ, Bhullar HK, Garratt CJ, Woods KL, de Bono DP. Reproducibility and automatic measurement of QT dispersion. Eur Heart J. 1996;17:1035-1039. DOI: 10.1093/oxfordjournals.eurheartj.a014999
  • 19. Malik M, Acar B, Gang Y, Yap YG, Hnatkova K, Camm AJ. QT dispersion does not represent electrocardiographic interlead heterogeneity of ventricular repolarization. J Cardiovasc Electrophysiol 2000;11(8):835–43. DOI: 10.1111/j.1540-8167.2000.tb00061.x
  • 20. Hevia JC, Castro Hevia J, Antzelevitch C, Sánchez MD, Balea FD, Molina RZ et al. Tpeak-Tend and Tpeak-Tend Dispersion as Risk Factors for Ventricular Tachycardia/Ventricular Fibrillation in Patients With the Brugada Syndrome. Journal of the American College of Cardiology 2006; 2;47(9):1828-1834. DOI:10.1016/j. jacc.2005.12.049
  • 21. Yayla Ç, Özcan F, Aras D, Turak O, Özeke Ö, Çay S et al. Tp-e interval and Tp-e/QT ratio before and after catheter ablation in patients with premature ventricular complexes. Biomark Med. 2017;11(4):339-46. DOI: 10.2217/bmm-2016-0263
  • 22. Antzelevitch C, Sicouri S, Di Diego JM, Burashnikov A, Viskin S, Shimizu W et al. Does Tpeak-Tend provide an index of transmural dispersion of repolarization? Heart Rhythm. 2007;4(8):1114–1116. Author reply 6–9. DOI: 10.1016/j.hrthm.2007.05.028
  • 23. Kardys I, Kors JA, van der Meer IM, Hofman A, van der Kuip DA, Witteman JC. Spatial QRS‐T angle predicts cardiac death in a general population. European Heart Journal. 2003;24, 1357–1364. DOI: 10.1016/s0195-668x(03)00203-3
  • 24. Zhang ZM, Prineas RJ, Case D, Soliman EZ, Rautaharju PM et al. Comparison of the prognostic significance of the electrocardiographic QRS/T angles in predicting incident coronary heart disease and total mortality (from the atherosclerosis risk in communities study). Am J Cardiol.2007;100(5):844–849. DOI: 10.1016/j.amjcard.2007.03.104
  • 25. Loring Z, Hanna P, Pellegrini CN. Longer ambulatory ECG monitoring increases the identification of clinically significant ectopy. Pacing Clin Electrophysiol. 2016;39:592–597. DOI: 10.1111/pace.12852

The relationship between frontal QRS-T angle and premature ventricular contraction burden in ambulatory 24-hour Holter

Year 2022, , 200 - 206, 20.08.2022
https://doi.org/10.30565/medalanya.1131541

Abstract

Aim: Frequent premature ventricular contractions (PVCs) can cause impaired ventricular function or dilatation of ventricular cavities. The frontal plane QRS-T [f(QRS-T)] angle is an indicator of instability in the electrophysiological properties of the myocardium and is associated with arrhythmias. The present study aimed to investigate whether f(QRS-T) angle, as a marker of ventricular repolarization heterogeneity, predicts premature ventricular contraction burden in ambulatory 24-hour Holter.

Methods: The study included 100 patients. The patients were divided into two groups as ‘frequent PVC’ and ‘seldom PVC’ according to their PVC burden in 24-hour Holter monitoring. Laboratory and some ambulatory electrocardiography parameters, including frontal plane QRS-T angle, were compared between the two groups.

Results: Frontal QRS-T angle (63.34±37.86° vs 23.46±14.29° p<0.001) was found to be wider in the Frequent PVC group. F(QRS-T) angle of ≥ 34° had a sensitivity of 82.2% and a specificity of 80% in indicating PVC load (AUC: 0.887 (0.824-0.950). In addition, a positive correlation was found between PVC burden and f(QRS-T) angle (r:0.429 p<0.001).

Conclusion: The widening of f(QRS-T) angle could perhaps be considered as a surrogate marker of increased PVC burden in 24-hour Holter monitoring. Measuring f(QRS-T) angle in 12-lead ECG in patients with PVC may be a warning sign for increased PVC burden.

References

  • 1. Saurav A, Smer A, Abuzaid A, Bansal O, Abuissa H. Premature Ventricular Contraction Induced Cardiomyopathy. Clin. Cardiol. 2015; 38, 4, 251–58 DOI: 10.1002/clc.22371
  • 2. Kennedy HL, Whitlock JA, Sprague MK, Kennedy LJ, Buckingham TA, Goldberg RJ. Longterm follow-up of asymptomatic healthy subjects with frequent and complex ventricular ectopy. N Engl J Med 1985;312:193–97. DOI: 10.1056/NEJM198501243120401
  • 3. Dukes JW, Dewland TA, Vittinghoff E, Mandyam MC , Heckbert SR , Siscovick DS et al. Ventricular ectopy as a predictor of heart failure and death. J. Am. Coll. Cardiol. 2015; 66(2), 101–09 DOI: 10.1016/j.jacc.2015.04.062
  • 4. Shvilkin A, Anter E. Cardiomyopathy-inducing premature ventricular contractions: not all animals are equal? Heart Rhythm 2012;9(9),1473–74. DOI: 10.1016/j.hrthm.2012.06.027
  • 5. Latchamsetty R, Bogun F. Premature ventricular complex induced cardiomyopathy. Rev. Esp. Cardiol. (Engl. Ed.). 2016;69(4), 365–369 DOI: 10.1016/j.rec.2015.12.015
  • 6. Lin C-Y, Chang S-L, Lin Y-J, Lo Li-W , Chung F-P, Chen Y-Y et al. Long-term outcome of multiform premature ventricular complexes in structurally normal heart. International Journal of Cardiology 2015;180:80-85. DOI: 10.1016/j.ijcard.2014.11.110.
  • 7. Ruberman W, Weinblatt E, Goldberg JD, Frank C W, Chaudhary B S, Shapiro S et al. Ventricular premature complexes and sudden death after myocardial infarction. Circulation 1981; 64(2): 297-305. DOI: 10.1161/01.cir.64.2.297
  • 8. Macfarlane PW. The frontal plane QRS-T angle. Europace. 2012;14(6):773–75. DOI: 10.1093/europace/eus057
  • 9. Oehler A, Feldman T, Henrikson CA, Tereshchenko LG. QRS-T angle: a review. Ann Noninvasive Electrocardiol. 2014;19(6):534–42. DOI: 10.1111/anec.12206
  • 10. Aro AL, Huikuri HV, Tikkanen JT, Junttila MJ, Rissanen HA, Reunanenet A al. QRS-T angle as a predictor of sudden cardiac death in a middle-aged general population. Europace. 2012;14(6):872–76. DOI: 10.1093/europace/eur393
  • 11. Raposeiras-Roubin S, Virgos-Lamela A, Bouzas-Cruz N, López-López A , Castiñeira-Busto M, Fernández-Garda R et al. Usefulness of the QRS-T angle to improve long-term risk stratification of patients with acute myocardial infarction and depressed left ventricular ejection fraction. Am J Cardiol. 2014; 113(8):1312–1319. DOI: 10.1016/j.amjcard.2014.01.406
  • 12. Jogu HR, O'Neal WT, Broughton ST, Shah AJ, Zhang Z-M, Solimanet EZ al. Frontal QRS-T angle and the risk of atrial fibrillation in the elderly. Ann Noninvasive Electrocardiol. 2017;22(2):e12388. DOI: 10.1111/anec.12388
  • 13. Lazzeroni D, Bini M, Camaiora U, Castiglioni P, Moderato L, Ugolotti TP et al. Prognostic value of frontal QRS-T angle in patients undergoing myocardial revascularization or cardiac valve surgery. J Electrocardiol. 2018;51(6):967-972. DOI: 10.1016/j.jelectrocard.2018.08.028
  • 14. Baman TS, Lange DC, Ilg KJ, Gupta SK, Liu TY, Alguire C et al. Relationship between burden of premature ventricular complexes and left ventricular function. Heart Rhythm 2010;7(7):865-9. DOI: 10.1016/j.hrthm.2010.03.036
  • 15. Zhang ZM, Rautaharju PM, Prineas RJ, Tereshchenko L, Soliman EZ. Electrocardiographic QRS-T angle and the risk of incident silent myocardial infarction in the Atherosclerosis Risk in Communities study. J Electrocardiol. 2017;50(5):661–666. DOI: 10.1016/j.jelectrocard.2017.05.001
  • 16. Massing MW, Simpson RJ Jr, Rautaharju PM, Schreiner P J, Crow R, Heiss G. Usefulness of ventricular premature complexes to predict coronary heart disease events and mortality (from the Atherosclerosis Risk in Communities Cohort). Am J Cardiol 2006;98:1609e12. DOI: 10.1016/j.amjcard.2006.06.061
  • 17. Agarwal SK, Simpson RJ Jr, Rautaharju P, Alonso A, , Shahar EC, Massing M et al. Relation of ventricular premature complexes to heart failure (from the Atherosclerosis Risk In Communities [ARIC] study). Am. J. Cardiol. 2012;109(1), 105–109. DOI: 10.1016/j.amjcard.2011.08.009
  • 18. Glancy JM, Weston PJ, Bhullar HK, Garratt CJ, Woods KL, de Bono DP. Reproducibility and automatic measurement of QT dispersion. Eur Heart J. 1996;17:1035-1039. DOI: 10.1093/oxfordjournals.eurheartj.a014999
  • 19. Malik M, Acar B, Gang Y, Yap YG, Hnatkova K, Camm AJ. QT dispersion does not represent electrocardiographic interlead heterogeneity of ventricular repolarization. J Cardiovasc Electrophysiol 2000;11(8):835–43. DOI: 10.1111/j.1540-8167.2000.tb00061.x
  • 20. Hevia JC, Castro Hevia J, Antzelevitch C, Sánchez MD, Balea FD, Molina RZ et al. Tpeak-Tend and Tpeak-Tend Dispersion as Risk Factors for Ventricular Tachycardia/Ventricular Fibrillation in Patients With the Brugada Syndrome. Journal of the American College of Cardiology 2006; 2;47(9):1828-1834. DOI:10.1016/j. jacc.2005.12.049
  • 21. Yayla Ç, Özcan F, Aras D, Turak O, Özeke Ö, Çay S et al. Tp-e interval and Tp-e/QT ratio before and after catheter ablation in patients with premature ventricular complexes. Biomark Med. 2017;11(4):339-46. DOI: 10.2217/bmm-2016-0263
  • 22. Antzelevitch C, Sicouri S, Di Diego JM, Burashnikov A, Viskin S, Shimizu W et al. Does Tpeak-Tend provide an index of transmural dispersion of repolarization? Heart Rhythm. 2007;4(8):1114–1116. Author reply 6–9. DOI: 10.1016/j.hrthm.2007.05.028
  • 23. Kardys I, Kors JA, van der Meer IM, Hofman A, van der Kuip DA, Witteman JC. Spatial QRS‐T angle predicts cardiac death in a general population. European Heart Journal. 2003;24, 1357–1364. DOI: 10.1016/s0195-668x(03)00203-3
  • 24. Zhang ZM, Prineas RJ, Case D, Soliman EZ, Rautaharju PM et al. Comparison of the prognostic significance of the electrocardiographic QRS/T angles in predicting incident coronary heart disease and total mortality (from the atherosclerosis risk in communities study). Am J Cardiol.2007;100(5):844–849. DOI: 10.1016/j.amjcard.2007.03.104
  • 25. Loring Z, Hanna P, Pellegrini CN. Longer ambulatory ECG monitoring increases the identification of clinically significant ectopy. Pacing Clin Electrophysiol. 2016;39:592–597. DOI: 10.1111/pace.12852
There are 25 citations in total.

Details

Primary Language English
Subjects Clinical Sciences, ​Internal Diseases
Journal Section Research Article
Authors

Görkem Kuş 0000-0002-6058-5501

Göksel Çağırcı 0000-0001-9768-918X

Publication Date August 20, 2022
Submission Date June 16, 2022
Acceptance Date July 19, 2022
Published in Issue Year 2022

Cite

Vancouver Kuş G, Çağırcı G. The relationship between frontal QRS-T angle and premature ventricular contraction burden in ambulatory 24-hour Holter. Acta Med. Alanya. 2022;6(2):200-6.

9705 

Bu Dergi Creative Commons Atıf-GayriTicari-AynıLisanslaPaylaş 4.0 Uluslararası Lisansı ile lisanslanmıştır.