COVID-19’lu Hastalarda Hipofosfateminin Morbidite ve Mortalitesi ile İlişkisi

Year 2023, , 137 - 144, 29.10.2023

Faruk Karandere , Deniz Yılmaz , Felemez Arslan , Ezgi Şahin , Sema Koyuncu

https://doi.org/10.30565/medalanya.1296968

Abstract

Amaç: Kritik hastalıklarda hipofosfatemi gibi elektrolit bozukluklarının mortalite ile ilişkisi gösterilmiştir. Biz de çalışmamızda COVID-19’lu hastalarda bir elektrolit bozukluğu olan hipofosfateminin mortalite ile ilişkisini incelemeyi amaçladık.

Gereç ve Yöntemler: Bu retrospektif kesitsel çalışma, hastanemizde COVID-19 tanısı alıp, yatarak tedavi gören hastaları içermektedir. Hastalar, serum fosfor düzeylerine göre iki gruba ayrılmıştır: serum fosfor düzeyi 2.5 mg/dl'nin altında olanlar (hipofosfatemi) ve bu seviyenin üzerinde olanlar (hipofosfatemi olmayanlar). İki grup arasındaki karşılaştırmalar, çeşitli istatistiksel yöntemler kullanılarak yapılmış ve sonuçlar bu veriler ışığında değerlendirilmiştir.

Bulgular: Hipofosfatemi grubuyla karşılaştırıldığında, hipofosfatemi olmayan grupta DM (p<0,001) ve KBY (p=0,015) tanıları istatistiksel olarak anlamlı yüksekti. Fosfor grupları ile mortalite ve yatış süresi arasında da istatistiksel olarak anlamlı farklılık saptandı (p<0.001). Ayrıca yaş ve yatış süreleri sağ olanlara kıyasla exitus olanlarda istatistiksel olarak anlamlı yüksek bulundu (p<0.001; p=0.002).

Sonuç: Hipofosfatemi yapılan birçok çalışmada ve bizim çalışmamızda da olduğu gibi COVID-19’lu hastalarda mortalite ile ilişkisi gösterilmiştir ve şiddetli hastalığı öngörmede bir biyobelirteç olabilir.

Keywords

COVİD-19, Fosfor, Diyabetis Mellitus, Mortalite

Supporting Institution

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Project Number

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Thanks

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Association of Hypophosphatemia with Morbidity and Mortality in Patients with COVID-19

Abstract

Aim: In critical cases, electrolyte disturbances such as hypophosphatemia have been shown to be associated with mortality and in our study, we aimed to examine the relationship between hypophosphatemia, a symptom disorder with COVID-19, and death.

Material and Methods: This study is a retrospective, cross-sectional investigation that encompasses patients diagnosed with COVID-19 and subsequently admitted for treatment at our hospital. Based on their serum phosphate levels, the patients were bifurcated into two distinct categories: those with serum phosphate levels below 2.5 mg/dl, classified as hypophosphatemic, and those with levels above this benchmark, categorized as non-hypophosphatemic. The comparisons drawn between these two cohorts were facilitated using a range of statistical methodologies, and the resulting findings were subsequently analyzed and interpreted within this framework.

Results: Compared to the hypophosphatemia group, the diagnoses of DM (p<0.001) and CKD (p=0.015) were statistically significantly higher in the group without hypophosphatemia. A statistically significant difference was found between phosphorus groups and mortality and length of stay (p<0.001). In addition, age and length of hospitalization were found to be statistically significantly higher in those who died compared to those who were alive (p<0.001; p=0.002).

Conclusions: Hypophosphatemia has been shown to be associated with mortality in patients with COVID-19, as in many studies and in our study, and it may be a biomarker in predicting severe disease.

Keywords

COVID-19, Phosphorus, Diabetes Mellitus, Mortality

Project Number

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