The Assessment of Bone Metabolısm Parameters in Paedıatrıc patıents wıth Genu varum and Genu valgus deformıtıes

Year 2024, , 56 - 61, 30.04.2024

Hüseyin Kürüm , Şükrü Demir , Sefa Key

https://doi.org/10.30565/medalanya.1452540

Abstract

Aim: There are a limited number of studies in the literature explaining the relationship between bone metabolism parameters such as vitamin D, calcium (Ca), parathormone (PTH), magnesium (Mg), and alkaline phosphatase (ALP) and pediatric lower extremity coronal plane deformities.This study aimed to examine the impact of bone metabolism parameters on the development of genu varum or genu valgus deformities.

Methods: 45 patients with genu varum and genu valgus whose vitamin D, Ca, PTH, Mg and ALP parameters were evaluated in our polyclinic were included in the study.

Results: 44 (97.8%) of the patients were bilateral and one (2.2%) was unilateral. The mean age of patients with genu varum (4.3±4.8) was significantly lower than that of patients with genu valgus (11.9±4.1) (p<0.001). Ca values were normal in 44 (97.8%), vitamin D in 23 (51.1%), PTH in 33 (73.3%), ALP in 2 (4.4%) and Mg in 43 (95.6%) patients. 3% (6.7) of the patients had comorbidities. 2 of these (66.7%) were rickets.

Conclusion: The study shows that ALP can be used as a screening test especially in the coming years. In addition, although there are no sufficient incidence and prevalence studies in the literature, we can say that genu varum is seen more frequently and mostly bilaterally than genu valgus.It is not uncommon for rickets to accompany lower extremity coronal deformities in children. In addition, McCune-Albright Syndrome (MAS) may be accompanied not only by fibrous dysplasia (FD) but also by bilateral genu valgum deformity.

Keywords

Genu varum, genu valgus, bone metabolism parameters

Ethical Statement

Approval for the study was given by the local Ethics Committee (2021/01-04).

Thanks

We would like to thank Murat Kürüm for his contribution to the conduct of the study.

Genu varum ve genu valgus deformitesi olan pediatrik hastalarda kemik metabolizmasi parametrelerinin değerlendirilmesi

Abstract

Amaç: Literatürde D vitamini, kalsiyum (Ca), parathormon (PTH), magnezyum (Mg) ve alkalen fosfataz (ALP) gibi kemik metabolizması parametreleri ile pediatrik alt ektremite koronal plan deformiteleri arasındaki ilişkiyi açıklayan sınırlı sayıda çalışma mevcuttur. Bu çalışmanın amacı, kemik metabolizması parametrelerinin genu varum veya genu valgus deformitelerinin oluşumundaki rolünü araştırmaktır.

Yöntemler: Polikliniğimizde D vitamini, Ca, PTH, Mg ve ALP parametreleri değerlendirilen 45 genu varum ve genu valguslu hasta retrospektif olarak çalışmaya dahil edildi.

Bulgular: Hastaların 44'ü (%97.8) bilateral, biri (%2.2) unilateral idi. Genu varumlu hastaların yaş ortalaması (4.3±4.8) genu valguslu hastalara (11.9±4.1) göre anlamlı derecede düşüktü (p<0.001). Ca değerleri 44 (%97,8), D vitamini 23 (%51,1), PTH 33 (%73,3), ALP 2 (%4,4) ve Mg 43 (%95,6) hastada normaldi. Hastaların 3'ünde (%6,7) ek patoloji vardı. Bunların 2'si (%66,7) raşitizmdi.

Sonuç: Çalışma, ALP'nin özellikle önümüzdeki yıllarda bir tarama testi olarak kullanılabileceğini göstermektedir. Ayrıca literatürde yeterli insidans ve prevalans çalışması olmamakla birlikte genu varumun genu valgusa göre daha sık ve çoğunlukla bilateral olarak görüldüğünü söyleyebiliriz. Riketsin çocuk alt ekstremite koronal deformitelerine eşlik etmesi nadir değildir. Ayrıca McCune-Albright Syndrome (MAS) sendorumuna sadece fibröz displazi (FD) değil bilateral genu valgum deformitesi eşlik edebilir.

Keywords

Genu varum, genu valgus, kemik metabolizması parametreleri.

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