Investigation of Mean Platelet Volume/Platelet, Neutrophil/Leucocyte Ratio And Troponin Values in Geriatric Patients Admitted to Hospital with Ischaemic Stroke

Year 2024, , 130 - 136, 30.08.2024

Gül Şahika Gökdemir

https://doi.org/10.30565/medalanya.1493400

Abstract

Aim: The aim of this study was to investigate the mean MPV/PLT ratio, NLR and troponin I levels in geriatric patients admitted to hospital with acute ischaemic stroke (AIS) and to evaluate the prognostic value of these parameters. In this way, a better clinical decision can be provided in the evaluation and treatment processes of AIS patients.

Methods: Using a retrospective design, the data of geriatric patients admitted to hospital with a diagnosis of AIS were analyzed. Demographic characteristics, clinical findings, laboratory results and radiological findings were obtained from electronic medical records. Platelet volume, platelet count, neutrophil count, leukocyte count and troponin I levels were recorded as primary data and other demographic, clinical and laboratory parameters were recorded as secondary data.

Results: MPV/PLT ratio was significantly higher in AIS patients (0.04±0.02) compared to non-ischemic stroke patients (0.03±0.02) (p<0.001). Similarly, NLR (5.29±5.09) was significantly higher in AIS patients compared to the other group (1.93±0.87) (p<0.001). In addition, Troponin I level was significantly higher in AIS patients (10.48±7.88 ng/mL) than the other group (2.18±1.11 ng/mL) (p<0.001).

Conclusion: This study demonstrates the predictive value of mean MPV/PLT ratio, NLR, and troponin I levels in geriatric patients admitted to hospital with AIS. Using these parameters in clinical evaluations may be helpful in the follow-up of AIS patients and in determining treatment strategies.

Keywords

Ischaemic stroke, Mean Platelet Volume/Platelet ratio, Neutrophil/Leukocyte ratio, Troponin I

Ethical Statement

This study was approved by the scientific research ethics committee of Mardin Artuklu University (Date: 10.07.2023, decision no 2023/7-12).

Supporting Institution

None

Thanks

I would like to thank the data processing and documentation staff of our hospital for their devoted contributions

Hastaneye İskemik inme ile Başvuran Geriatrik Hastalarda Ortalama Trombosit Hacmi/Trombosit, Nötrofil/Lökosit Oranı Ve Troponin Değerlerinin Araştırılması

Abstract

Amaç: Bu çalışmanın amacı, iskemik inme ile hastaneye başvuran geriatrik hastalarda ortalama MPV/PLT oranı, NLR ve troponin I düzeylerini araştırmak ve bu parametrelerin prognostik değerlerini değerlendirmektir. Bu şekilde, iskemik inme hastalarının değerlendirme ve tedavi süreçlerinde daha iyi bir klinik karar verme sağlanabilir.

Yöntem: Geriye dönük bir tasarım kullanılarak, iskemik inme tanısıyla hastaneye başvuran geriatrik hastaların verileri retrospektif olarak incelendi. Hastaların demografik özellikleri, klinik bulguları, laboratuvar sonuçları ve radyolojik bulguları elektronik tıbbi kayıtlardan elde edildi. Trombosit hacmi, platelet sayısı, nötrofil sayısı, lökosit sayısı ve troponin I düzeyleri primer veriler, diğer demografik, klinik ve laboratuvar parametreleri de ikincil veriler olarak kaydedildi.

Bulgular: MPV/PLT oranı, iskemik inme hastalarında (0,04±0,02) iskemik inme olmayan hastalara (0,03±0,02) göre anlamlı oranda daha yüksek olarak gözlemlendi (p<0,001). Benzer olarak iskemik inme hastalarında NLR (5,29±5,09), diğer gruba oranla (1,93±0,87) anlamlı oranda daha yüksek idi (p<0,001). Buna ek olarak Troponin I düzeyi, iskemik inme hastalarında (10,48±7,88 ng/mL) diğer gruptan (2,18±1,11 ng/mL) bariz olarak yüksek idi (p<0,001).

Sonuç: Bu çalışma, iskemik inme ile hastaneye başvuran geriatrik hastalarda ortalama MPV/PLT oranı, NLR ve troponin I düzeylerinin prognostik değerlerini ortaya koymaktadır. Bu parametrelerin klinik değerlendirmelerde kullanılması, iskemik inme hastalarının takibinde ve tedavi stratejilerinin belirlenmesinde yardımcı olabilir.

Keywords

İskemik inme, Ortalama Trombosit Hacmi /Platelet oranı, Nötrofil/Lökosit oranı, Troponin I

References

• 1. Yılmaz Avcı A, Demir AM, Utku U, Vural AÖ, Ekuklu G. The relationship between serum interleukin-6 levels with lesion size and early functional worsening in acute ischemic stroke Acta Med Alanya. 2018;2(2):102-10. doi: 10.30565/medalanya.386697
• 2. Zhu H, Hu S, Li Y, Sun Y, Xiong X, Hu X, et al. Interleukins and Ischemic Stroke. Front Immunol. 2022;13:828447. doi: 10.3389/fimmu.2022.828447
• 3. Feske SK. Ischemic Stroke. Am J Med. 2021;134(12):1457-64. doi: 10.1016/j.amjmed.2021.07.027.
• 4. Chen Z, He Y, Su Y, Sun Y, Zhang Y, Zhang Y, et al. Association of inflammatory and platelet volume markers with clinical outcome in patients with anterior circulation ischaemic stroke after endovascular thrombectomy. Neurol Res. 2021;43(6):503-10. doi: 10.1080/01616412.2020.1870359.
• 5. Guldolf K, Vandervorst F, Gens R, Ourtani A, Scheinok T, De Raedt S. Neutrophil-to-lymphocyte ratio predicts delirium after stroke. Age Ageing. 2021;50(5):1626-32. doi: 10.1093/ageing/afab133.
• 6. Lim HH, Jeong IH, An GD, Woo KS, Kim KH, Kim JM, et al. Early prediction of severity in acute ischemic stroke and transient ischemic attack using platelet parameters and neutrophil-to-lymphocyte ratio. J Clin Lab Anal. 2019;33(3):e22714. doi: 10.1002/jcla.22714.
• 7. Xu SL, Yang J, Zhang CF, Xu SY, Zhao FY, Liu LQ, et al. Serum cardiac troponin elevation predicts mortality in patients with pulmonary hypertension: A meta-analysis of eight cohort studies. Clin Respir J. 2019;13(2):82-91. doi: 10.1111/crj.12991.
• 8. Aly M, Abdalla RN, Batra A, Shaibani A, Hurley MC, Jahromi BS, et al. Follow-up neutrophil-lymphocyte ratio after stroke thrombectomy is an independent biomarker of clinical outcome. J Neurointerv Surg. 2021;13(7):609-13. doi: 10.1136/neurintsurg-2020-016342
• 9. Peng F, Zheng W, Li F, Wang J, Liu Z, Chen X, et al. Elevated mean platelet volume is associated with poor outcome after mechanical thrombectomy. J Neurointerv Surg. 2018;10(1):25-8. doi: 10.1136/neurintsurg-2016-012849.
• 10. Wada H, Dohi T, Miyauchi K, Shitara J, Endo H, Doi S, et al. Mean platelet volume and long-term cardiovascular outcomes in patients with stable coronary artery disease. Atherosclerosis. 2018;277:108-12. doi: 10.1016/j.atherosclerosis.2018.08.048.
• 11. Gao L, Zhang H, Zhang B, Zhang L, Wang C. Prognostic value of combination of preoperative platelet count and mean platelet volume in patients with resectable non-small cell lung cancer. Oncotarget. 2017;8(9):15632–41. doi: 10.18632/oncotarget.14921.
• 12. Chen CT, Li LH, Su PY, Chang YC, Lee IH, Yen DH, et al. Neutrophil-to-lymphocyte ratio in predicting neurological outcome of patients with acute ischemic stroke treated with intravenous thrombolytics. J Chin Med Assoc. 2022;85(1):102-8. doi: 10.1097/JCMA.0000000000000599.
• 13. Li L, Han Z, Wang R, Fan J, Zheng Y, Huang Y, et al. Association of admission neutrophil serine proteinases levels with the outcomes of acute ischemic stroke: a prospective cohort study. J Neuroinflammation. 2023;20(1):70. doi: 10.1186/s12974-023-02758-1.
• 14. Li LH, Chen CT, Chang YC, Chen YJ, Lee IH, How CK. Prognostic role of neutrophil-to- lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune inflammation index in acute ischemic stroke: A STROBE-compliant retrospective study. Medicine (Baltimore). 2021;100(25):e26354. doi: 10.1097/MD.0000000000026354.
• 15. Gong P, Liu Y, Gong Y, Chen G, Zhang X, Wang S, et al. The association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and lymphocyte to monocyte ratio with post- thrombolysis early neurological outcomes in patients with acute ischemic stroke. J Neuroinflammation. 2021;18(1):51. doi: 10.1186/s12974-021-02090-6.
• 16. Bsat S, Halaoui A, Kobeissy F, Moussalem C, El Houshiemy MN, Kawtharani S, et al. Acute ischemic stroke biomarkers: a new era with diagnostic promise? Acute Med Surg. 2021;8(1):e696. doi: 10.1002/ams2.696.
• 17. Sun Y. Biomarkers for Acute Ischemic Stroke: a New Era with Promise for Diagnostics. J. Experi. Stroke. Trans. Med. 2023;15(3):59-62. doi: 10.37532/ jestm.2023.15(3).59-62
• 18. Scheitz JF, Endres M, Mochmann H-C, Audebert HJ, Nolte CH. Frequency, determinants and outcome of elevated troponin in acute ischaemic stroke patients. Int J Cardiol. 2012;157(2):239-42. doi: 10.1016/j.ijcard.2012.01.055