Migren ve periferik inflamasyon

Year 2017, , 127 - 134, 15.12.2017

Aynur Yılmaz Avcı , Oktay Akalin

https://doi.org/10.30565/medalanya.336902

Cited By: 2

Abstract

Amaç: Migren inflamasyon ve  vasküler hastalıklar ile ilişkili olabilen
yaygın bir baş ağrısı türüdür. Biz genç erişkin migren hastalarında C-reaktif
protein ve periferik kandaki bağışık hücre sayısını değerlendirdik.

Hastalar ve Yöntem: Bu olgu-kontrol çalışması,
260 migren hastası (aurasız, 169 olgu, auralı, 91 olgu) ve 260 sağlıklı kontrol
katılımcı (yaş aralığı, 18-50 yıl) olmak üzere 520 kişiyi içermektedir.
Katılımcıların hiçbirinde bilinen bir anemi, vasküler risk faktörü veya
inflamatuar hastalık yoktu. Migren ve kontrol olgularında serum C-reaktif
protein ve tam kan sayımı parametrelerini değerlendirdik.

Bulgular: C-reaktif protein, lökosit, nötrofil,
lenfosit, trombosit sayıları ve ortalama trombosit hacmi migren hastalarında
kontrol grubuna (P <0.001) oranla anlamlı olarak farklıydı. Ancak bu
parametreler, C-reaktif protein hariç, auralı ve aurasız migrenlerde benzerdi.
Lojistik regresyon analizinde migren hastalığı C-reaktif protein seviyesi (OR,
2.36; 95% CI, 1.73 ile 3.23; P< 0.001), ortalama trombosit hacmi (odds ratio
[OR], 2.32; 95% confidence interval [CI], 1.78 - 3.0; P<0.001), ve lökosit
sayısı (OR, 1.61; 95% CI, 1.32 - 1.94; P< 0.001) ile anlamlı olarak
ilişkiliydi. 

Sonuç: Periferik inflamasyonun artmış seviyeleri
migren hastalarında ortaya çıkabilir ve migren patogenezinde rol oynayabilir.           

Keywords

Tam kan sayımı, C-reaktif protein, başağrısı, lökosit, lenfosit, trombosit

Migraine and peripheral inflammation

Abstract

Aim: Migraine is a common
headache disorder that may be associated with inflammation and vascular
diseases. We evaluated C-reactive protein and the number of immune cells in the
peripheral blood of young adult patients with migraine.

Patients and
Methods:
This case–control study included 520 subjects: 260 patients with migraine
(without aura, 169 patients; with aura, 91 patients) and 260 healthy control
subjects (age range, 18–50 years). Participants had no known anemia, vascular
risk factors, or inflammatory diseases. We evaluated serum C-reactive protein
and complete blood count parameters in patients with migraine and control
subjects.

Results: C-reactive protein level,
leukocyte, neutrophillymphocyte, platelet counts and mean platelet volume
significantly differed in patients with migraine compared to controls
(P<0.001). However, with the exception of C-reactive protein, these
parameters were similar in migraine with and without aura. Logistic regression
analysis showed that migraine was significantly associated with C-reactive
protein level (odds ratio [OR], 2.36; 95% confidence interval [CI],
1.73–3.23; P<0.001), MPV (OR, 2.32; 95% CI, 1.78–3.0;
P<0.001), and leukocyte count (OR, 1.61; 95% CI,
1.32–1.94;).

Conclusion: Increased levels of
peripheral inflammation may occur in patients with migraine and may be involved
in the pathogenesis of migraine.

Keywords

Complete blood count, C-reactive protein, headache, leukocyte, lymphocyte, platelet

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