Hücre İskeleti Yapıları ve Hastalıklarla Etkileşimleri

Year 2019, , 197 - 202, 23.08.2019

Abdullah Melekoğlu , Oğuz Karahan

https://doi.org/10.30565/medalanya.528070

Abstract

Araştırmacılar, ileri teknolojiye sahip farklı hastalıklar için farklı temeller bildirmişlerdir. Bu arada, son zamanlarda temel hücresel mekanizmaların etkileşimlerini netleştirmek için birçok araştırma yapılmıştır. Bu nedenle, hücre iskeleti araştırmaları bu eğilim nedeniyle önem kazanmaktadır. Hücre iskeleti yapıları, hücre çekirdeği, sitoplazma ve ayrıca hücre dışı matriks arasındaki bağlantılardan sorumludur, böylece hücresel moleküller ve sinyalizasyon iletimi arasında bir iletişim bağlantısı oluşturur. Hücre iskeleti, üç çeşit protein filamanından oluşur: aktin filamentleri, ara filamentler ve mikrotübüller. Bu makalede, bu yapıların niteliği kısaca özetlenmiştir ve hücre iskeleti bileşenleri ile yaygın hastalıklar arasındaki ilişkiyi bildiren literatür taraması sunulmuştur. 

Keywords

Hücre iskeleti, Aktin filamentleri, ara filamentler, mikrotübül, hastalık etkileşimleri

Structures of Cytoskeleton and Disease Interactions

Abstract

Researchers reported different basics for different kind of diseases with advanced technology. Meanwhile, investigators are focused on to clarify the interactions of basic cellular mechanisms recently. Therefore, cytoskeletal researches are gain importance due to this tendency. The cytoskeletal structures are responsible for interconnects between cell nucleus, cytoplasm and also extracellular matrix, whereby it creates a communication link between cellular molecules and signalization transport. The cytoskeleton is constructed from three kinds of protein filaments as: actin filaments, intermediate filaments, and microtubules. The nature of these structures is briefly outlined and the literature review that is reporting the relationship between cytoskeleton components and common disorders is presented in this paper. 

Keywords

Cytoskeleton, actin filaments, intermediate filaments, microtubules, disease interactions

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