The relationship between procalcitonin, D-dimer, ferritin, troponin and lactate levels with COVID-19

Year 2021, , 30 - 35, 23.04.2021

Levent Şahin , Ali Gür

https://doi.org/10.30565/medalanya.808806

Cited By: 2

Abstract

Aim: Coronavirus disease-2019 patients may experience an increase in inflammation or clotting disorders. It is believed that some biomarkers can be decisive in decision to hospitalize. Our aim in this study was to investigate the relationship between serum procalcitonin, troponin, D-dimer, ferritin and lactate levels, and Coronavirus disease-2019.

Methods: Patients suspected of suffering from the Coronavirus disease-2019 and whose serum biochemistry and blood gas tests were performed, were included in the study. The relationships between the blood parameters of the patients with negative or positive Polymerase Chain Reaction test results, and those who were hospitalized or non-hospitalized, were examined.

Results: Out of a total of 452 patients, 244 (54%) were male and 208 (46%) were female. There was a statistically significant difference between polymerase chain reaction test positive and test negative groups in terms of procalcitonin, D-dimer, lactate and troponin levels (p˂0.005). There was no statistically significant difference between hospitalized and non hospitalized patient in terms of ferritin (p=0.224). However, there was a significant difference in terms of procalcitonin, D-dimer and troponin levels (p˂0.005).

Conclusion: Our results revealed that high serum procalcitonin, D-dimer, lactate and troponin levels are associated with the decision to hospitalize Coronavirus disease- 2019 patients, whereas ferritin levels played no such role.

Keywords

Coronavirus disease-2019,, procalsitonin,, D-dimer,, troponin,

Prokalsitonin, D-Dimer, Ferritin, Troponin ve Laktat Düzeylerinin COVID-19 Hastalığı ile İlişkisi

Abstract

Amaç: Koronavirüs hastalığı-2019 hastalarında enflamasyon artışı veya pıhtılaşma bozukluğu artışı görülebilmektedir. Bazı biyobelirteçlerin, hastaneye yatış yapılmasında belirleyici olabileceği düşünülmektedir. Bu çalışmadaki amacımız, serum prokalsitonin, troponin, D-dimer, ferritin ve laktat düzeyleri ile Koronavirüs hastalığı-2019 arasındaki ilişkiyi araştırmaktı.

Metod: Koronavirüs hastalığı-2019 şüphesi olan, kan biyokimya ve kan gazı tetkikleri çalışılan hastalar çalışmaya dahil edildi. Polimeraz zincir reaksiyonu test sonuçları negatif veya pozitif olan hastalar ve taburcu veya servise yatışı yapılan hastaların kan sonuçları arasındaki ilişkileri incelendi.

Bulgular: Toplam 452 hastanın, 244 (% 54)‘ü erkek ve 208 (%46)’i kadın idi. Polimeraz zincir reaksiyonu testi pozitif olan grup ile negatif olan grup arasında prokalsitonin, D-dimer, laktat ve troponin düzeyleri istatistiksel olarak anlamlı bulundu (p˂0.005). Yatış yapılan hastalar ile yapılmayan hastalar arasında ferritin seviyesinde istatistiksel olarak bir anlamlılık yoktu (p=0.224). Ancak prokalsitonin, D-dimer, troponin seviyelerinde anlamlı bir farklılık çıktı (p˂0.005).

Sonuç: Elde ettiğimiz sonuçlarla yüksek serum prokalsitonin, D-dimer, laktat ve troponin düzeylerinin Koronavirüs hastalığı-2019 hastalarının hastaneye yatışı ile ilişkisinin olduğunu söyleyebiliriz. Ancak ferritin düzeylerinin hastaneye yatış endikasyonunda bir rolü yoktu.

Keywords

COVID-19, prokalsitonin, D-Dimer, troponin

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