The relationship between the second trimester screening biochemical markers and complications and anomalies in pregnant women.

Year 2017, Volume: 1 Issue: 1, 7 - 10, 23.04.2017

Hasan Basri Savaş , Seyit Ali Köse Mesut Güler Fatih Gültekin

https://doi.org/10.30565/medalanya.265994

Cited By: 1

Abstract

Aim: We aimed to
investigate the relationship between AFP, uE3, beta hCG, maternal age and Down
syndrome, NTD and trisomy 18 risk levels and prenatal maternal or fetal
complications, postnatal chromosomal anomalies, emergence of high or low
birthweight births, in pregnant with triple test.

 Method: The pregnancy complications occurred during pregnancy
of 82 patients, whose triple screens were done in our clinic during the years
of 2010-2012, were investigated retrospectively, and post pregnant chromosomal
abnormalities, neural tube defects (NTDs), high and low birth weight cases were
found out by calling the patients and by searching their files. Multiple of
median (MoM) values were calculated by measuring AFP, uE3, and beta hCG levels
with chemiluminescent method via Beckman Coulter UniCelDxI
800 device.           

Results: The average age of the women in the study group was
27.7. The risk has been identified, for Down syndrome in 8 patients, for NTD in
10 patients, for trisomy 18 in 3 patients, over 1/250. The number of patients
with preeclampsia was 2; gestational diabetes mellitus (DM) was 8 during
pregnancy. While the number of babies born with low birthweight was 13, high
birthweight infants’ number was 11.

Conclusion:
In order to determine false postivities more properly, further studies
with a higher number of cases are recommended. Advanced clinical trials are
recommended for increasing the safety of pregnancy screening tests.

Keywords

Triple screening test, chromosomal abnormalities

Gebelerde ikinci trimester tarama testinde biyokimyasal belirteçler ile gebelik komplikasyonları arasındaki ilişki

Abstract

Amaç: Downsendromu, neural tube defects (NTDs),  ve
trizomi 18 riskinin ve ayrıca AFP,uE3 ve beta hCG
seviyelerinin her biri ile doğum öncesi maternal veya fetal komplikasyonların
ve doğum sonrası kromozomal anomalilerin, NTD,
yüksek veya düşük ağırlıklı doğumların ortaya çıkması ile ilişkisini araştırmayı
amaçladık.

 Yöntem:
Kliniğimizde
2010-2012 yılları arasında üçlü tarama testi yapılmış olan 82 hastada gebelik
sırasında ortaya çıkan komplikasyonlar retrospektif olarak incelenmiş ve
gebelik sonrası kromozomal anomali, NTD, yüksek ve düşük doğum ağırlıklı doğum
olma durumu ise hasta dosyalarından ve telefonla görüşülerek öğrenilmiştir.
AFP, uE3 ve βhCG seviyeleri Beckman Coulter UniCelDxI 800 cihazında,
kemilüminesans yöntemiyle ölçülerek MoM değerleri hesaplanmıştır.

 Bulgular:
Çalışma
grubundaki gebelerin yaş ortalaması 27,7’dir. 8 hastada Downsendromu riski, 10
hastada NTD riski, 3 hastada trizomi 18 riski 1/250’nin üzerinde tespit
edilmiştir. Gebelik sırasında preeklampsisi olan hasta sayısı 2,
gestasyoneldiyabetesmellitusu (DM) olan hasta sayısı ise 8 idi. Düşük doğum
ağırlıklı doğan bebek sayısı 13 iken yüksek doğum ağırlıklı doğan bebek sayısı
11’dir.

 Sonuç: Yanlış
pozitifliklerin daha doğru belirlenmesi için olgu sayısının daha fazla olduğu
çalışmalar yapılması ve tarama testlerinin güvenirliklerinin artırılması için
gelişmiş klinik araştırmalar yapılması önerilir.

Keywords

Üçlü tarama testi, kromozomal anomaliler

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