A Case of Parathyroid Carcinoma with Presented Lung Metastases

Year 2018, Volume: 2 Issue: 3, 206 - 209, 13.11.2018

Hasret Cengiz , Süleyman Baş , Yasemin Tütüncü

https://doi.org/10.30565/medalanya.403856

Abstract

Parathyroid
carcinoma is one of the rarest endocrinologic tumors.  It covers on average  %1 of all hyperparathyroid  cases. It can be seen as a part of genetic
syndromes  or generally as sporadic
cases. Man/Woman ratio is 0,8/1 . 90% of parathyroid carcinoma is usually
hormonally active and presents with hypercalcemia clinic, and in many cases
also a palpable  or detectable big
neck  mass is  present. Our case is an exciting and rare
case due to first presentation is hypercalcemia and hyperparathyroidia with
lung methastazes without detectable parathyroid 
mass in neck.

 

Keywords

Parathyroid Carcinoma, Lung methastazes, Case report

Akciğer Metastazları ile Görülen Paratiroid Karsinomu Olgusu

Abstract

Paratiroid karsinomu en nadir görülen  endokrin tümörlerden biridir.
Hiperparatiroidi vakalarının ortalama %1 ini oluşturur.  Sporadik olarak görülebildiği gibi, genetik
bir sendromun komponenti  olarak da
görülebilir. E/K oranı 0,8/1 dir. Paratiroid 
karsinomlarının %90’ı hormonal olarak aktiftir ve  hiperkalsemi  kliniği ile prezente olurlar. Ayrıca birçok
vakada boyunda palpabl  büyük bir kitle
de bulunur. Bizim vakamız preoperatif görüntülemelerde primer tümör ile ilgili
hiçbir iz bulunamamış; akciğer metastazları ile prezente olmuş  nadir ve heyecan verici bir vakadır

Keywords

Paratiroid Karsinomu, Akciğer metastazı, Olgu sunumu

References

• 1. Wei CH, Harari A, et al. Parathyroid carcinoma:update and guidelines for management.Current Treat Options Oncol. 2012 Mar;13[1]:11-23.
• 2. Vila Duckworth L. et al. İntrathyroidal parathyroid carcinoma:report an unusual case andr eview of literature. Case Rep. Pathol. 2013;2013:198643-48.
• 3. Verges MP, Herges HI, Kleiner DE, et al.The role of prognostic markers [MIB-1,RB and bcl-2] in the diagnosis of parathyroid tumors.Modern Pathology.1997;10[1]:12-17.
• 4. Vasef MA, Brynes RK, et al. Expression of cyclin D1 in parathyroid carcinomas,adenomas and hyperplasias:a parafin immunohistochemical study .modern Pathol. 1999;12[4]:412-16.
• 5. Erickson LA, Jin L, Wollen P,T hompson GB. Paratihroid hyperplasia adenomas and carcınomas: a differential expression of P27[kip 1] protein.American Journal of Surgical Pathol.1999;23[3]:288-295.
• 6. Tan M, Morrison C, Wang P, et al. Loss of parafibromin immunoreactivity is a distinguishing feature of parathyroidcarcinoma. ClinicalCancerResearch. 2004;10[19]:6629–6637.
• 7. Owen RP ,Silver CE, Pellitteri PK et al. Parathyroid Carcinoma:areview. Head and Neck 2011;33:429.
• 8. Shaha AR, Ferlito A, et al. Distant methastasis from throid and parathyroid cancer.OrlJ.Otorhinolarangeal.Relatspec 2001 Jul-Aug;63[4]:243-9.
• 9. Obara T, Okamoto T,et al. Functioning parathroid carcinoma, clinicopathologic features and rational treatment.Semin .surg Oncol 1997 Mar-April;13[2]:134-41.
• 10. Yamamoto T, Matsumura A. Comment on ‘Clinicalreview 122:Parathyroid Carcınoma’. J Clin Endocrinol Metab 2001:86;5091.
• 11. Hundley JC, Albertson FA, et al.Resection of pulmonary methastasis from parathroid carcinoma .Am Surg 2003 Sp;69[9]:779-83.
• 12. Van Hooven ER ,Kievit J, et al. Successfull resection for hepatic and pulmonary methastazis in a patient with parathyoid carcınoma.Jpn J Clin. Oncol.1996 ap;26[2]:99-102.
• 13. Obara J,Okamoto T, et al. Surgical and medical management of patients with pulmonary methastasis from parathroid carcınoma.Surgery 1993 Dec;114[6]:1040-8.
• 14. Tochio M, Takali H, et al. A case report of 20 lung radiofrequencyablation sessions for 50 lung methastasis from parathroidcarcinoma causing hyperparathroidism.Cardiovasc. İntervent Radiol.2010 Jun;33[3]:657-9.
• 15. Kuhlencordt F, Lozano-Tonkin C, Kracht J, Bartelheimer H. Pulmonary nodüles as early sign of primary parathyroid carcinoma. Deutsch Med Wochenschr 1974 oct 4;99[40]:1957-60.