The Relationship Between Blood Neutrophil to Lymphocyte Ratio and Tumor Size, Tumor Number, Macrovascular Invasion in Patients with Hepatocellular Carcinoma

Year 2019, Volume: 3 Issue: 3, 207 - 212, 26.10.2019

Özlem Özer Çakır

https://doi.org/10.30565/medalanya.551550

Abstract

Aim: We aimed to show the relationship between blood neutrophil to lymphocyte ratio that is systemic inflammatory marker and tumor size, tumor number, macro-vascular invasion at the time of diagnosis in patients with hepatocellular carcinoma.

Methods: A total 48 patients diagnosed with hepatocellular carcinoma were included in our study. The patients were divided into two groups according to the median neutrophil to lymphocyte ratio.

Results: A total of 48 patients (11 female, 37 male) were included in our study. The mean age of the patients were 67.18±9.51 years-old. The median neutrophil to lym-phocyte ratio was 3.17. There were significant association between neutrophil to lym-phocyte ratio > 3.17 and macrovascular invasion, the tumor number> 3, the tumor size> 5 cm, Child-Turcot-Pugh score, Model for End-stage Liver Disease- Sodium score, C-reactive protein and blood sodium level (p: 0.005, p: 0.009, p< 0.001, p: 0.003, p:0.008, p: 0.035 and p < 0.001, respectively). Multiple logistic lineer regres-sion analysis showed that NLR> 3.17 was an independent predictor of tumor size> 5 cm and hyponatremia in patients with hepatocellular carcinoma (p: 0.010, p: 0.012, respectively).

Conclusions: The value of blood neutrophil to lymphocyte ratio at the time of diag-nosis in patients with hepatocellular carcinoma was a good predictor of tumor size and grade of disease. 

Keywords

Neutrophil to lymphocyte ratio, Tumor size, Hepatocellular carcinoma

Hepatosellüler Karsinomalı Hastalarda Kan Nötrofil Lenfosit Oranı ile Tümör Boyutu, Tümör Sayısı ve Makrovasküler İnvazyon Arasındaki İlişki

Abstract

Amaç: Hepatosellüler Karsinomu olan hastalarda tanı anındaki tümör boyutu, tümör sayısı ve makrovasküler invazyon ile kan nötrofil lenfosit oranı arasındaki ilişkiyi göstermeyi amaçladık. 

Hastalar ve Method: Çalışmaya toplam 48 hepatosellüler karsinomalı hasta dahil edildi. Hastalar ortalama nötrofil lenfosit oranına göre ikiye bölündü. 

Bulgular: Toplam 48 hastanın 11’i kadın, 37’si erkek idi. Hastaların ortalama yaşı 67,18±9,51 idi. Ortalama nötrofil lenfosit oranı 3,17 idi. Nötrofil lenfosit oranı (NLR)>3,17 olan hastalarda makrovasküler invazyon, tümör sayısının>3, tümör boyutu>5 cm, Child-Turcot-Pugh skor, Model for End-stage Liver Disease- Sodyum skor, C-reaktif protein and kan sodyum seviyesi ile arasında istatistiksel olarak anlamlı birliktelik izlendi (p: 0.005, p: 0.009, p< 0.001, p: 0.003, p:0.008, p: 0.035 ve p < 0.001, sırasıyla). Multiple lojistik lineer regresyon analizİ; hepatosellüler karsinomlu hastalarda NLR> 3.17 olması tumor boyutu> 5 cm and hiponatreminin bağımsız bir belirteci olduğunu gösterdi (p: 0.010, p: 0.012, sırasıyla). 

Sonuç: Hepatosellüler karsinomalı hastalarda tanı anındaki kan nötrofil lenfosit oranının değeri, tümör boyutunun ve hastalık evresinin iyi bir belirtecidir. 

Keywords

Nötrofil lenfosit oranı, Tümör boyutu, Hepatoselüler karsinoma

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