Effects of Tumor Necrosis Factor Alpha Blocker Adalimumab in Experimental Brain Injury

Year 2019, Volume: 3 Issue: 3, 306 - 310, 26.10.2019

Mehmet Yalçın Günal , Seyda Cankaya , Sukru Burak Tonuk , Ekrem Musa Ozdemir Ayse Arzu Sayın Sakul

https://doi.org/10.30565/medalanya.632455

Abstract

Aim: We aimed to investigate the neuroprotective role of adalimumab based on the hypothesis that "TNF-alpha inhibitor Adalimumab may affect inflammation-related neuronal injury due to its anti-inflammatory effect". 

Methods: To investigate the effects of Adalimumab, we induced brain injury in mice using a cold trauma model and evaluated the underlying cell survival/ death mechanisms via cresyl violet and calculated infarct/edema volume with image analyze system. 

Results: Although our data indicated a tendency to decreased infarct and edema volume, these findings are not significant statistically. 

Conclusion: To the best of our knowledge, this is the first study evaluating the neuroprotective effect of Adalimumab on injured neurons. 

Keywords

brain injury, Adalimumab, neural protection

Tümör Nekroz Faktörü Alfa Blokeri Adalimumabın Deneysel Beyin Hasarında Etkileri

Abstract

Amaç: “TNF-alfa inhibitörü Adalimumab’ın, anti-inflamatuvar etkisi nedeniyle inflamasyonla ilişkili nöronal hasarı etkileyebileceği” hipotezine dayanarak Adalimumab’ın nöroprotektif rolünü araştırmayı amaçladık. 

Metotlar: Adalimumab’ın etkilerini araştırmak için soğuk travma modelini kullanarak farelerde beyin hasarı oluşturduk ve krezil viyole boyasıyla hücre sağ-kalım/ölüm oranları ile görüntü analiz sistemi ile hesaplanan infarktüs/ödem hacmini değerlendirdik. 

Bulgular: Verilerimiz infarkt ve ödem hacminde azalma eğilimi göstermesine rağmen istatistiksel olarak anlamlı değildir. 

Sonuç: Bildiğimiz kadarıyla çalışmamız Adalimumab’ın hasarlı nöronlar üzerindeki nöroprotektif etkisini değerlendiren ilk çalışmadır. 

Keywords

beyin hasarı, Adalimumab, nöroprotektif etki

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