Investigation of the Endothelial Response of Super Elastic Braided Stent: An Experimental Evaluation

Year 2020, Volume: 4 Issue: 3, 236 - 241, 29.10.2020

Oğuz Karahan , Naci Öcal , Tuğçe Sümer , Erhan Hafız , Emced Khalil

https://doi.org/10.30565/medalanya.745576

Abstract

Aim: This study aimed to experimentally investigate the vascular biocompatibility of the new super elastic braided stents and ultrasonographically follow up the mid-term outcomes on the blood flow of stent-implanted vessels.

Method: After designation of the study steps, stents were implanted into the iliac arteries of two ewes. The preoperative and postoperative blood flow and local findings were noted. The ewes were inspected periodically for abnormal body changes, and the stent-implanted vessels were checked with Doppler ultrasonography. The subjects were sacrificed at six months, and the iliac arteries were examined histopathologically.

Results: During follow up an occlusive pattern was not observed in the stent-implanted vessels. The histopathological analysis revealed that both two stent area had no significant neointimal hyperplasia, despite sufficient re-endothelisation at the stent surface. Occlusive or stenotic patterns were not detected in both macroscopic and microscopic findings.

Conclusion: According to the mid-term findings, our results show that the new super elastic bare stents have good vascular biocompatibility with high patency rates.

Keywords

Super elastic bare stent, vascular biocompatibility, neointimal hyperplasia, experimental model

Süper Elastik Örgülü Stentin Endotel Yanıtının İncelenmesi: Deneysel Bir Değerlendirme

Abstract

Amaç: Bu çalışmada yeni süper elastik çıplak stentlerin vasküler biyoyararlanımının deneysel olarak araştırılması ve stent implante edilen damarların kan akışındaki orta dönem sonuçlarının ultrasonografik olarak izlenmesi amaçlandı.

Yöntem: Çalışma adımlarının belirlenmesinden sonra stentler iki koyun ilyak arterlerine implante edildi. Ameliyat öncesi ve sonrası kan akışı ve lokal bulgular kaydedildi. Denekler anormal vücut değişiklikleri açısından periyodik olarak takip edildi ve stent implante edilen damarlar Doppler Ultrasonografi ile kontrol edildi. Denekler 6. ayda sakrifiye edildi ve iliak arterler histopatolojik olarak incelendi.

Bulgular: Takip sırasında stent implante edilmiş damarlarda herhangi bir oklüzyon paterni gözlenmedi. Histopatolojik analiz, stent yüzeyinde yeterli yeniden endotelizasyona rağmen, her iki stent bölgesinin de belirgin neointimal hiperplazi olmadığını ortaya koydu. Makroskopik veya mikroskopik bulgularda oklüzif veya stenotik patern saptanmadı.

Sonuç: Sonuçlarımız, yeni süper elastik çıplak stentlerin, orta dönem bulgularına göre yüksek açıklık oranları ile iyi vasküler biyoyararlılığa sahip olduğunu göstermiştir.

Keywords

Super elastic çıplak stent, vasküler biyouyumluluk, neointimal hiperplazi, deneysel model

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