Gaucher Hastalığı olan Olgularda SARS-CoV-2 enfeksiyonu

Year 2023, Volume: 5 Issue: 2, 231 - 6, 15.05.2023

Burcu Civelek Ürey , Çiğdem Seher Kasapkara , Aslı İnci , Mehmet Gündüz , Aslınur Özkaya Parlakay , Leyla Tumer , Asburce Olgac

https://doi.org/10.37990/medr.1139421

Abstract

COVID-19 Infection in Patients with Gaucher Disease

Abstract

Aim: Coronavirus disease 2019 (COVID-19) is a severe acute respiratory syndrome with a high mortality rate and has been labeled a global pandemic in March 2020. Gaucher Disease (GD) is one of the rare inherited lysosomal storage diseases (LSDs). We aimed to call attention to the frequency, susceptibility of COVID-19 infection, and the factors that prevent this infection in patients with GD as compared to other LSDs.
Material and Methods: The study was conducted retrospectively between September and December 2020. Participants were divided into two groups: GD group (19 patients) and the control group (19 patients, those with other LSDs). All patients were contacted by phone to collect data about their health status, and any possible contact with Covid-19 patients.
Results: Six of the GD patients (36.8%) had contacted a confirmed COVID-19 infected person but only three (15.8%) had developed a mild COVID-19 with fever and fatigue that did not require hospital admission. Four of the control group patients (21.1%) had experienced contact with a person with a confirmed COVID-19 infection. Three of the control group patients, that comprised of patients with various LSDs other than GD (15.8%) were positive on COVID-19 PCR tests and two of them had developed a mild COVID-19 infection. One of these (with Mucopolysaccharidosis type 1) had severe symptoms and required hospitalization.
Conclusion: There is no consensus on the management of rare diseases such as lysosomal storage diseases during the COVID-19 pandemic. Developing plans regarding the management of COVID-19 infections in LSDs will be useful when drawing up consensus guidelines.

Keywords

Gaucher disease, lysosomal storage disorders, COVID-19

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