Cellular Response of Cancer to Music: Mirror, Mirror, on the Wall, Which is the Most Effective of Them All?

Year 2023, Volume: 5 Issue: 2, 237 - 43, 15.05.2023

Ceren Elbe , Melike Özgül Önal , Gürkan Yiğittürk , Seda Gelen Turan , Hülya Elbe

https://doi.org/10.37990/medr.1173999

Abstract

Aim: Cancer is one of the most common health problems in the world. Music is a therapy method that creates positive changes in human behavior. This study aims to examine the effects of Turkish and Western classical music on MCF-7, SKOV-3, PC-3, U87, and COLO741 cancer cell lines.
Material and Methods: Group 1: No sound, Group 2: Turkish classical music (ney), Group 3: Western classical music (piano), and Group 4: Western classical music (violin). After listening to the cancer cells for 40 min, the audio files were interrupted for 1h, and then music was played for another 40 min. The effect of music on the proliferation of cancer cells was determined by WST-1 cell viability analysis. Statistical analyzes were performed with the SPSS program.
Results: There was no statistically significant difference between the groups that were applied music once in only the MCF-7 breast cancer cells and the control group (p>0.05). A statistically significant decrease was detected in cell viability when the control group and the other groups that were applied to music twice were compared (p<0.05). For other cancer cell lines except (please the SKOV-3 ovarian cancer cells, it was determined that music application once also caused a statistically significant decrease in cell viability (p<0.05).
Conclusion: We determined that classical music effectively reduced and suppressed the number of cancer cells. According to the data, Turkish and Western classical music can be used to support the treatment in of cancer patients.

Keywords

Breast cancer, prostate cancer, colon cancer, ovarian cancer, glioblastoma, turkish classical music, western classical music

References

• Referans 1. Ministry of Health of the Republic of Turkey. Turkey Cancer Statistics. 2017.
• Referans 2. Ferlay J, Ervik M, Lam F, Colombet M, Mery L, Piñeros M, Znaor A, Soerjomataram I, Bray F. Global cancer observatory: Cancer today. Lyon: International Agency for Research on Cancer. 2020.
• Referans 3. Lafci D, Oztunc G. The effect of music on the sleep quality of breast cancer patients. International Journal of Caring Sciences. 2015; 8 : 633-640.
• Referans 4. Akpinar NB, Ceran MA, Özkalp B. The effect of classical Turkish and Western music on university students’ exam stress level, blood pressure and pulse rate: a randomized controlled trial. J Health Sci Med. 2020; 3 : 216-220. doi: 10.32322/jhsm.681640.
• Referans 5. Somakcı P. Türklerde müzikle tedavi. Erciyes Üniversitesi Sosyal Bilimler Enstitüsü Dergisi. 2003; 15 : 131-140.
• Referans 6. Lestard NR, Capella MA. Exposure to music alters cell viability and cell motility of human nonauditory cells in culture. Evid Based Complement Alternat Med. 2016;2016:6849473. doi: 10.1155/2016/6849473.
• Referans 7. Sezer F. The psychological impact of Ney music. The Arts in Psychotherapy. 2012; 39: 423-427. doi:10.1016/j.aip.2012.07.003.
• Referans 8. Lestard NR, Valente RC, Lopes AG, Capella MA. Direct effects of music in non-auditory cells in culture. Noise Health. 2013; 15: 307-314. doi: 10.4103/1463-1741.116568.
• Referans 9. Karamızrak N. Healing effects of sound and music on the organs. Kosuyolu Heart Journal. 2014; 17: 54-57. doi: 10.4274/khj.4775.
• Referans 10. Marshall OW, Tomcala M. Effects of different genres of music on stress levels. East Texas State University. 1981.
• Referans 11. Yıldırım S, Gurkan A. The influence of music on anxiety and the side effects of chemotherapy. Anatolian Journal of Psychiatry. 2007; 8: 37‑45.
• Referans 12. Ramirez-River S, Bernal G. Music is capable of inducing changes in gene expression in gastric cancer cells. J Gastrointest Cancer. 2019; 50: 175-180. doi: 10.1007/s12029-019-00203-2.