Helikobakter Pilori Enfeksiyonu ile Nötrofil-Lenfosit Oranı, Trombosit-Lenfosit Oranı Ve Nötrofil-Monosit Oranları Arasındaki İlişki

Year 2023, Volume: 5 Issue: 2, 349 - 54, 15.05.2023

Ferit Çelik , Aslı Kılavuz

https://doi.org/10.37990/medr.1249261

Abstract

Amaç: Çalışmamızda nötrofil-lenfosit oranı, trombosit-lenfosit oranı, nötrofil-monosit oranı ve ortalama trombosit hacmi ile Helikobakter pilori pozitifliği ve şiddeti arasındaki ilişkiyi göstermeyi amaçladık.
Yöntem ve Gereçler: Çalışmaya Temmuz 2021 ile Temmuz 2022 tarihleri arasında bir devlet hastanesinde dispeptik şikâyetleri nedeniyle üst gastrointestinal sistem endoskopisi yapılmış, aktif ve/veya kronik hastalığı olmayan 596 hasta dahil edildi. Demografik ve laboratuvar verileri hasta kayıtlarından retrospektif olarak elde edildi. Hastalar patoloji raporuna göre Helikobakter pilori pozitif ve negatif olarak iki gruba ayrıldı. Helikobakter pilori varlığı; yok, hafif, orta ve şiddetli olarak tanımlandı. Gruplar arasında hemogram parametreleri karşılaştırıldı.
Bulgular: Hastaların (n=596) yaş ortalaması 41,8 ± 13,57 yıl, 374 (%62,8)’ü kadın ve 331 (%55,5)’i Helikobakter pilori pozitifti. Helikobakter pilori pozitif ve negatif hasta grupları arasında yaş, cinsiyet, lökosit, lenfosit, monosit, trombosit, hemoglobin, nötrofil-lenfosit oranı, trombosit-lenfosit oranı, nötrofil-monosit oranı ve ortalama trombosit hacmi değerleri açısından istatistiksel olarak anlamlı fark saptanmadı. Helikobakter pilori şiddetine göre hemogram parametreleri değerlendirildiğinde gruplar arasında sadece lenfosit düzeyleri açısından istatistiksel olarak anlamlı farklılık saptanmıştır (p = 0,028). Fakat bu farklılık klinik olarak anlamlı kabul edilmemiştir.
Sonuç: Nötrofil-lenfosit oranı, trombosit-lenfosit oranı, nötrofil-monosit oranı ve ortalama trombosit hacminin son zamanlarda popüler olan ve birçok sistemik hastalıkta teşhis ve inflamasyonun derecesi konusunda kolay, erişilebilir ve ucuz parametreler olduğu düşünülüyor, ancak bizim çalışmamızda Helikobakter pilori pozitifliği ve şiddeti ile hemogram parametreleri arasında istatistiksel olarak anlamlı bir ilişki bulunmamıştır. Helikobakter pilori enfeksiyonu için bu parametrelerin prediktör olarak kabul edilebilmesi için daha fazla sayıda olgu içeren prospektif çalışmalara ihtiyaç vardır.

Keywords

Helikobakter pilori, nötrofil-lenfosit oranı, trombosit-lenfosit oranı, nötrofil-monosit oranı.

Project Number

None

Association of Helicobacter Pylori Infection with Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Neutrophil-to-Monocyte Ratio

Abstract

Aim: In our study, we aimed to show the relationship between neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, neutrophil-monocyte ratio and mean platelet volume, and Helicobacter pylori positivity and severity.
Material and Methods: In this study, we included 596 patients without active and/or chronic disease who underwent upper gastrointestinal system endoscopy due to dyspeptic complaints in a state hospital between July 2021 and July 2022. Demographic and laboratory data were obtained retrospectively from electronic patient records. The patients were divided into two groups as positive and negative for Helicobacter pylori according to the pathology report. Helicobacter pylori presence was defined as none, mild, moderate and severe. Hemogram parameters were compared between the groups.
Results: Mean age of the patients (n=596) was 41.8±13.57 years, 374 (62.8%) were female, and 331 (55.5%) were Helicobacter pylori positive. There was no statistically significant difference between Helicobacter pylori positive and negative patient groups in terms of age, gender, leukocytes, lymphocytes, monocytes, platelets, hemoglobin, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, neutrophil-monocyte ratio and mean platelet volume values. When the hemogram parameters were evaluated according to the severity of Helicobacter pylori, a statistically significant difference was found between the groups only in terms of lymphocyte levels (p=0.028). However, this difference was not considered clinically significant.
Conclusion: Neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, neutrophil-monocyte ratio and mean platelet volume are thought to be popular recently and easy, accessible and inexpensive parameters for diagnosis and degree of inflammation in many systemic diseases, but in our study, no statistically significant relationship was found between Helicobacter pylori positivity and severity and hemogram parameters. Prospective studies with larger numbers of cases are needed to accept these parameters as predictors for Helicobacter pylori infection.

Keywords

Helicobacter pylori, neutrophil-lymphocyte ratio, thrombocyte-lymphocyte ratio, neutrophil-monocyte ratio

Supporting Institution

None

Project Number

None

Thanks

None

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