Investigation of the Sox-9 and Caspase-6 Immune Activity in Placentas of Pregnant Women with GDM

Year 2023, Volume: 5 Issue: 3, 445 - 8, 18.09.2023

Ece Öcal , Senem Alkan Akalın , Engin Deveci

https://doi.org/10.37990/medr.1252256

Abstract

Aim: In this study, we investigated the immunohistochemical staining of Sox-9 and Caspase-6 expression in placentas of pregnant woman with gestational diabetes mellitus (GDM).
Material and Methods: Placentas of 20 healthy and 20 women with GDM were processed for routine histological tissue processing. The biochemical and clinical parameters of patients were recorded. Placentas were stained with hematoxylin-eosin and Sox-9 and Caspase-6 immunostaining.
Results: In control group, Sox-9 expression was negative in decidual and connective cells and endothelial cells. In GDM group, Sox-9 expression was increased especially in the decidual cells. For the Caspase-6 expression, Caspase-6 reaction was mainly in maternal region in control group. In GDM group, Caspase-6 reaction was increased in decidual cells, in endothelial cells and in the syncytial nodes.
Conclusion: Expression of Sox-9 transformed the decidua cells and lead to apoptotic pathway via Caspase-6 expression.

Keywords

Sox-9, caspase-6, GDM, placenta

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