The Effect of Vagus Nerve Stimulation Applications on Taste and Smell Loss in COVID-19 Syndrome: Case Report

Year 2023, Volume: 5 Issue: 3, 655 - 8, 18.09.2023

Berkay Eren Pehlivanoğlu , Sanem Güven , Sefa Haktan Hatık , Ali Veysel Özden

https://doi.org/10.37990/medr.1262924

Abstract

Loss of the sense of taste and smell is a common side effect of Covid 19. It is thought that transcutaneous ear vagus nerve stimulation may affect taste and smell as a result of neural connections. We present a 27-year-old female participant diagnosed with loss of taste and smell for more than 1 year. The Connecticut Chemosensory Clinical Research Center (CCCRC) olfactory test was used to test the sense of smell. To test the sense of taste, 3 drops of taste test were applied. It was found that during the application period of 1 session per day for 15 days, there was a progressive improvement in the sense of taste and smell. However, it was found that the effect was not significant in restoring the sense of smell and the ability to distinguish odors.

Keywords

Covid 19, Vagus Nerve Stimulation, Anosmia, Ageusia

Supporting Institution

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Project Number

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Thanks

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References

• 1. Umakanthan S, Sahu P, Ranade A V, et al. Origin, transmission, diagnosis and management of coronavirus disease 2019 (COVID-19). Postgrad Med JPostgrad Med J. 2020;96:753- 8.
• 2. Najafloo R, Majidi J, Asghari A, et al. Mechanism of anosmia caused by symptoms of COVID-19 and emerging treatments. ACS Chem Neurosci. 2021;12:3795-805.
• 3. Khani E, Khiali S, Beheshtirouy S, Entezari-Maleki T. Potential pharmacologic treatments for COVID-19 smell and taste loss: a comprehensive review. Eur J Pharmacol. 2021;912:174582.
• 4. Cain WS, Goodspeed RB, Gent JF, et al. Evaluation of olfactory dysfunction in the Connecticut chemosensory clinical research center. The Laryngoscope. 1998;98:83-8.
• 5. Veyseller B, Ozucer B, Karaaltin AB, et al. Connecticut (CCCRC) olfactory test: normative values in 426 healthy volunteers. Indian J Otolaryngol Head Neck Surg. 2014;66:31-4.
• 6. Sperling W, Biermann T, Spannenberger R, et al. Changes in gustatory perceptions of patients with major depression treated with vagus nerve stimulation (VNS). Pharmacopsychiatry. 2011;44:67–71.
• 7. Whitcroft KL, Hummel T. Olfactory Dysfunction in COVID-19: diagnosis and management. JAMA. 2020;323:2512-4.
• 8. Haehner A, Draf J, Dräger S, De With K, Hummel T. Predictive value of sudden olfactory loss in the diagnosis of COVID-19. ORL. 2020;82:175–80.
• 9. Moein ST, Hashemian SMR, Mansourafshar B, et al. Smell dysfunction: a biomarker for COVID-19. Int Forum Allergy Rhinol. 2020;10:944-50.
• 10. Mueller C, Temmel AFP, Quint C, Rieger A, Hummel T. Olfactory function in HIV-positive subjects. Acta Otolaryngol. 2002;122:67-71.
• 11. Kaniusas E, Szeles JC, Kampusch S, et al. Non-invasive auricular vagus nerve stimulation as a potential treatment for COVID19-Originated acute respiratory distress syndrome. Front Physiol. 2020;11:890.
• 12. Kirchner A, Landis BN, Haslbeck M, et al. Chemosensory function in patients with vagal nerve stimulators. J Clin Neurophysiol. 2004;21:418-25.