Investigation of the Effect of Propolis on Penicillin Induced Epileptiform Activity in Rats

Year 2023, Volume: 5 Issue: Supplement (1) - Innovations in Medicine and Healthcare in the 100th Year of the Republic, 97 - 103, 19.10.2023

Ersin Beyazçiçek

https://doi.org/10.37990/medr.1348722

Cited By: 1

Abstract

Aim: The aim of this study was to investigate the effects of propolis (PP), which has antioxidant and neuroprotective effects, on penicillin-induced epileptiform activity in rats.
Material and Methods: Forty-two adult male Wistar rats were divided into 6 groups as control (CONT), penicillin (PEN), diazepam (DZM), only propolis (OPP), 50 mg/kg propolis (PP50), and 100 mg/kg propolis (PP100). ECoG recording was taken from rats. At the end of the experiment, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and malondialdehyde (MDA) levels were determined from serum samples. Moreover, the latency of the first epileptiform activity, spike-wave frequency (SWF), and spike-wave amplitude (SWA) of the epileptiform activity were analyzed.
Results: The latency of the DZM and PP100 groups was found to be longer than the CONT groups. The time-dependent SWF and total SWF of the PP50 and PP100 groups were lower than the CONT group. No significant difference was found between the groups in terms of SWA. SOD, CAT, and GPx levels were found to be higher, but the MDA level was lower in PP50 and PP100.
Conclusion: As a result, propolis may be a potential antiepileptic drug candidate in the future with its antioxidant activity as well as prolonging latency and reducing SWF in epilepsy models.

Keywords

Epilepsy, Propolis, Oxidative Stress, Penicillin, Electrocorticography

Supporting Institution

Düzce University Research Fund

Project Number

2021.04.01.1233

Thanks

We thank Ozge BEYAZÇİÇEK and Ali GOK for their help and support at Duzce University Experimental Animals Application and Research Center.

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