Clinical Research
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The Effect of Bilateral Intravitreal Ranibizumab Administration on Pain in Diabetic Retinopathy

Year 2024, Volume: 6 Issue: 1, 138 - 140, 31.01.2024
https://doi.org/10.37990/medr.1405514

Abstract

Aim: To investigate the effect of bilateral intravitreal ranibizumab (IVR) on pain in diabetic patients.
Material and Method: Of the 42 patients who underwent bilateral IVR for diabetic retinopathy and macular edema, 42 eyes injected first were considered as group 1 and 42 eyes injected second were considered as group 2. During the injection, pain was assessed using a numerical scale (NS) and a verbal category scale (VCS) .
Results: The mean age of 20 male (47.7%) patients in the groups was 59.90±6.03 years, and the mean age of 22 female (52.3%) patients was 60.72±3.88 years (p=0.52). In Group 1, the NS was 3.78±1.11, while in Group 2 it was 4.14±1.37, the difference was statistically significant (p=0.01). In group 1, VCS was 2.30±0.71, while in group 2, VCS was 2.73±0.93, the difference was statistically significant (p=0.01).
Conclusion: In diabetic patients who underwent bilateral IVR in the same session, pain sensation in the first injected eye was found to be less. This should be taken into consideration in bilateral IVR application.

References

  • Wild S, Roglic G, Green A, et al. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047-53.
  • Küçükerdönmez C, Gelisken F, Yoeruek E, et al. Switching intravitreal anti-VEGF treatment in neovascular age-related macular degeneration. Eur J Ophthalmol. 2015;25:51-6.
  • Raj PP Ağri Taksonomisi. In: Erdine S, ed., Ağrı. Nobel Tıp Kitabevleri, İstanbul. 2000;12-9.
  • Black JM, Matasarrin-Jacobs E. Medical-surgical nursing, 4th edition, WB Saunders Co., London 1993;313-58.
  • Boccard E, Garbior JL. Pain and its expression in six European Countries: a survey. Pain Clin. 1996;9:77-88.
  • Aiello LP, Brucker AJ, Chang S et al. Evolving guidelines for intravitreous injections. Retina. 2004;24:S3-19.
  • Cintra LP, Lucena LR, Da Silva JA et al. Comparative study of analgesic effectiveness using three different anesthetic techniques for intravitreal injection of bevacizumab. Ophthalmic Surg Lasers Imaging. 2009;40:13-8.
  • Ertan E, Duman R, Duman R. Comparison of pain during intravitreal dexamethasone, ranibizumab and aflibercept injection. Clin Exp Optom. 2020;103:630-3.
  • Shin SH, Park SP, Kim YK. Factors associated with pain following intravitreal injections. Korean J Ophthalmol. 2018;32:196-203.
  • Georgakopoulos CD. Tsapardoni F, Makri OE. Effect of bromfenac on paın related to intravitreal injections: a Randomized Crossover Study. Retina. 2017;37:388-95.
Year 2024, Volume: 6 Issue: 1, 138 - 140, 31.01.2024
https://doi.org/10.37990/medr.1405514

Abstract

References

  • Wild S, Roglic G, Green A, et al. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047-53.
  • Küçükerdönmez C, Gelisken F, Yoeruek E, et al. Switching intravitreal anti-VEGF treatment in neovascular age-related macular degeneration. Eur J Ophthalmol. 2015;25:51-6.
  • Raj PP Ağri Taksonomisi. In: Erdine S, ed., Ağrı. Nobel Tıp Kitabevleri, İstanbul. 2000;12-9.
  • Black JM, Matasarrin-Jacobs E. Medical-surgical nursing, 4th edition, WB Saunders Co., London 1993;313-58.
  • Boccard E, Garbior JL. Pain and its expression in six European Countries: a survey. Pain Clin. 1996;9:77-88.
  • Aiello LP, Brucker AJ, Chang S et al. Evolving guidelines for intravitreous injections. Retina. 2004;24:S3-19.
  • Cintra LP, Lucena LR, Da Silva JA et al. Comparative study of analgesic effectiveness using three different anesthetic techniques for intravitreal injection of bevacizumab. Ophthalmic Surg Lasers Imaging. 2009;40:13-8.
  • Ertan E, Duman R, Duman R. Comparison of pain during intravitreal dexamethasone, ranibizumab and aflibercept injection. Clin Exp Optom. 2020;103:630-3.
  • Shin SH, Park SP, Kim YK. Factors associated with pain following intravitreal injections. Korean J Ophthalmol. 2018;32:196-203.
  • Georgakopoulos CD. Tsapardoni F, Makri OE. Effect of bromfenac on paın related to intravitreal injections: a Randomized Crossover Study. Retina. 2017;37:388-95.
There are 10 citations in total.

Details

Primary Language English
Subjects Ophthalmology
Journal Section Original Articles
Authors

Mehmet Coşkun 0000-0001-7315-2994

Publication Date January 31, 2024
Submission Date December 15, 2023
Acceptance Date January 28, 2024
Published in Issue Year 2024 Volume: 6 Issue: 1

Cite

AMA Coşkun M. The Effect of Bilateral Intravitreal Ranibizumab Administration on Pain in Diabetic Retinopathy. Med Records. January 2024;6(1):138-140. doi:10.37990/medr.1405514

17741

Chief Editors

Assoc. Prof. Zülal Öner
Address: İzmir Bakırçay University, Department of Anatomy, İzmir, Türkiye

Assoc. Prof. Deniz Şenol
Address: Düzce University, Department of Anatomy, Düzce, Türkiye

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