Bilateral Ortak Karotis Arter Ligasyonu Sonrası Kraniyofacioservikal Resirkülasyon Sırasında Trigeminal Ağ ve Karotiko-vertebrobaziler Vaskülatürü Arasındaki Sihirli İlişki: Ön Çalışma

Year 2022, Volume: 6 Issue: 1, 9 - 15, 28.04.2022

Abdulkerim Olğun , Rabia Demirtaş , Aslıhan Alpaslan Duman , Mehmet Kürşat Karadağ , Mehmet Hakan Şahin , Sevilay Özmen , Mehmet Aydin

https://doi.org/10.29058/mjwbs.1082490

Abstract

Amaç: Steno-tıkayıcı karotid arter hastalığı, intralüminal basınç artışına, retrograd kan akışına, intralüminal genişlemeye, damar duvarı incelmesine, konvolüsyona, vasküler yeniden şekillenmeye, anjiyogenez ve anevrizma oluşumuna yol açar. Bu çalışmada bilateral ortak karotis arter ligasyonu (BCCAL) sonrası eksteral/internal karotis arterlerin (ECA/ICA) luminal yüzey alanı değerleri ile trigeminal ganglion (TGG) iskemisi arasında bir ilişki olup olmadığını ortaya koymayı amaçladık.
Gereç ve Yöntemler: Bu çalışma, kontrol (GA;n=5), SHAM (GB;n=5) ve çalışma grubu (GC,n=10) olmak üzere 20 melez erkek tavşan üzerinde gerçekleştirildi. Anterior mid-servikal insizyonu takiben, sadece GC için kalıcı BCCAL uygulandı ve denekler üç ay sonra genel anestezi altındasakrifiye edildi. TGG'lerin dejenere nöron (DN) yoğunluğu ve ECA/ICA'ların luminal yüzey değerleri Cavalieri ve Stereolojik yöntemler ile tahmin edildi. Karotis arter vaskülatüründe lümen genişlemesi, duvar incelmesi, uzama, konvolüsyon ve dolikoektazi varlığı tespit edildi.
Bulgular: TGG'nin ortalama DN yoğunluğu GA'da 12±4, GB'de 53±11 ve GC'de 960±112 idi. ECA’nı ortalama dal sayısı 4±1/GA, 7±2/GB ve 11±3/GC olarak hesaplandı. ECA/ICA'nın toplam yüzey değerleri (mm2 olarak) 4,8±1,2/GA; 3,9±0,8/GB ve 3,6±0,4/GC şeklinde hesaplandı.
Sonuç: TGG'deki düşük DN yoğunluğunun, çalışma grubunda, neovaskülarizasyon, kollateral gelişimi, karotis dolaşımının yeniden normalleşmesi ve çalışma grubunda ECA/ICA nedeniyle oluşan iskemik hasarın önlenmesi üzerinde faydalı bir etkisi olabilir.

Keywords

Karotis ligasyonu, trigeminal ganglion, eksteral karotis arter, internal karotis arter, revaskülarizasyon

A Magic Relationship Between Trigeminal Network and Carotico-vertebrobasilar Vasculature During Craniofaciocervical Recirculation Following Bilaterally Common Carotid Artery Ligation: Preliminary Study

Abstract

Aim: Steno-occlusive carotid artery disease causes increased intraluminal pressure, retrograde blood flow, intraluminal enlargement, vessel wall thinning, convolution, vascular remodelling, angiogenesis, and aneurysm formation. We investigated whether there is a relationship between trigeminal ganglion (TGG) ischemia and luminal surface area values of external/internal carotid arteries (ECA/ICA) after common carotid artery ligation (BCCAL).
Material and Methods: This study was conducted in 20 hybrid male rabbits as control (GA;n=5), SHAM (GB;n=5), and study group (GC,n=10). Following anterior mid-cervical incision, permanent BCCAL was performed for only GC and animals sacrificed under general anaesthesia after three months. Degenerated neuron (DN) density of TGGs and ECAs/ICAs' luminal surface values were estimated by Cavalieri and Stereological methods. Lumen enlargement, wall thinning, elongation, convolution, and dolichoectasia were detected in the carotid artery vasculature.
Results: The mean DN density of TGG was 12±4 in GA, 53±11 in GB, and 960±112 in GC. The mean number of ECA branches was calculated as 4±1/GA, 7±2/GB, and 11±3/GC. Total surface values of ECA/ICA (as mm2): 4.8±1.2/GA; 3.9±0.8/GB and 3.6±0.4/GC.
Conclusion: The low density of DN in TGG could have a beneficial effect on neovascularization, collateral development, a renormalization of carotid circulation, and prevention of ischemic damage supplied by ECA/ICA of study group.

Keywords

Carotid ligation, trigeminal ganglion, external carotid artery, internal carotid artery, revascularisation

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