Obstrüktif Uyku Apne Sendromu ve Ağrı: Kesitsel Bir Çalışma

Year 2023, Volume: 7 Issue: 3, 364 - 371, 31.12.2023

Nihal Yılmaz , Meryem Kösehasanoğulları , İzzet Göker Küçük

https://doi.org/10.29058/mjwbs.1378175

Abstract

Amaç: Bu çalışma, obstrüktif uyku apne sendromu (OUAS) tanısı alan hastalarda kronik yaygın kasiskelet
sistemi ağrısı (KYKİSA) ile nöropatik ağrı (NA) arasındaki ilişkiyi araştırmayı amaçlamaktadır..
Gereç ve Yöntemler: Bu kesitsel çalışma, 1 Mayıs 2017-1 Şubat 2018 tarihleri arasında Uşak
Üniversitesi Tıp Fakültesi Hastanesi uyku polikliniğinde gerçekleştirildi. Uyku polikliniğine uyku
bozukluğu şikayeti ile başvuran ve polisomnografi ile obstrüktif uyku apne sendromu tanısı konulan
ancak henüz bu amaçla tedavi görmemiş hastalar çalışmaya alındı.
Bulgular: Olguların polisomnografi sonuçları incelendiğinde 16 olguda hafif, 15 olguda orta ve 26
olguda ağır düzeyde obstrüktif uyku apne sendromu saptandı. Olguların %89'unda en az 1 bölgede
ağrı saptanırken, olguların %38,5'inde nöropatik ağrı (NA) saptandı. NA'nin obstrüktif uyku apne
sendromu derecesi arttıkça lineer olarak arttığı bulundu (p=0,049). Pittsburgh Uyku Kalitesi İndeksi
(PUKİ) puanlarına göre olguların %54'ünün (n=31) uyku kalitesi kötüydü, Sağlık Değerlendirme Ölçeği
puanlarına göre ise olguların %36'sının (n=21) yaşam kalitesi düşüktü
Sonuç: Obstrüktif uyku apne sendromu olanlarda KYKİSA ve NA'nın birbirine eşlik ettiği saptandı. Obstrüktif uyku apne sendromu derecesi
arttıkça NA prevalansı artmaktaydı. Obstrüktif uyku apne sendromu ile beraber ağrısı olanlarda yaşam kalitesi ve uyku kalitesi skorları daha
kötü bulundu. Obstrüktif uyku apne sendromu'lu kadınların erkeklere göre ağrı skorları daha yüksek ve yaşam kalitesi skorları daha düşük
bulundu.

Keywords

Uyku Apnesi, Obstrüktif, Kas İskelet Ağrısı, Nöropatik ağrı

Ethical Statement

Uşak Universitesi Girişimsel Olmayan Etik Kurulu (Onay tarihi: 07.06.2017, Onay numarası:: 2017-40).

Supporting Institution

Yok

Thanks

Yok

Obstructive Sleep Apnea Syndrome and Pain: A Cross-sectional Study

Abstract

Aim: The present study aims to investigate the relationship between chronic widespread musculoskeletal
system pain (CWP) and neuropathic pain (NP) among patients, who were diagnosed with obstructive
sleep apnea syndrome (OSAS).
Material and Methods: For this cross-sectional study, the study was carried out in sleep polyclinic of
Uşak University’s Medical Faculty Hospital between 1 May 2017 and 1 February 2018. The patients,
who applied to the sleep polyclinic for the complaint of sleep disorder and were diagnosed with OSAS by
using polysomnography (PSG) but haven’t had a treatment for this purpose yet, were involved..
Results: Examining the PSG results of participants, mild OSAS was detected in 16 cases, moderate
OSAS in 15 cases, and severe OSAS in 26 cases. Pain was detected in minimum 1 region in 89% of
the cases, whereas 38.5% of participants were found to have neuropathic pain (NP). NP was found to
linearly increase with an increase in degree of OSAS (p=0.049). According to Pittsburgh Sleep Quality
Index (PSQI) scores, 54% (n=31) of the participants had poor sleep quality, and according to Health
Assessment Questionnaire (HAQ) scale scores, 36% (n=21) of the participants had low quality of
life (QoL). When examining the differences between groups, due to the variables not being normally
distributed, the Mann Whitney U and Kruskal Wallis-H Tests were utilized. to investigate the relationships
among variables that do not follow a normal distribution, Spearman’s Correlation Coefficient was
employed.
Conclusion: CWP and NP were found to accompany each other among those with OSAS. The
prevalence of NP increases with an increase in degree of OSAS. The QoL and quality of sleep among
those with OSAS with pain were poorer than those having no pain. Women with OSAS were found to
have higher pain and lower QoL when compared to men.

Keywords

Sleep Apnea, Obstructive, Musculoskeletal Pain, Neuropathic pain

Ethical Statement

Upon the ethics committee approval was obtained from Uşak University’s Non-Interventional Researches Ethics Committee (Approval date: 07.06.2017, Approval number: 2017-40).

Supporting Institution

None

Thanks

None

References

• 1. UpToDate. Clinical presentation and diagnosis of obstructive sleep apnea in adults. Available from: URL: https://www.uptodate. com/contents/clinical-presentation-and-diagnosis-of-obstructive- sleep-apnea-in-adults. Accesed May 27, 2020.
• 2. Demir A, Ursavaş A, Tana Aslan A, Gülbay B, Çiftçi B, Çuhadaroğlu Ç, et al. Türk Toraks Derneği Obstrüktif Uyku Apne Sendromu Tanı Ve Tedavi Uzlaşı Raporu. Türk Toraks Dergisi 2012; 13(1):1-73.
• 3. Nicholas M, Vlaeyen JWS, Rief W, Barke A, Aziz Q, Benoliel R, et al. The IASP classification of chronic pain for ICD-11: chronic primary pain. Pain, 2019;160:28–37.
• 4. Aytekin E, Demir SE, Akyol Komut EA, Okur SÇ, Burnaz Ö, Çağlar SN, et al. Chronic widespread musculoskeletal pain in patients with obstructive sleep apnea syndrome and the relationship between sleep disorder and pain level, quality of life, and disability. J. Phys. Ther. Sci. 2015;27:2951–54.