Evaluation of the efficacy of isotretinoin treatment on neutrophil/lymphocyte ratio and the other hemogram parameters

Year 2013, Volume: 4 Issue: 13, 9 - 14, 03.03.2015

Pınar Özuğuz , Seval Kaçar Serap Polat Sena Ulu Şemsettin Karaca

Abstract

Aim: There are reports of various side effects of isotretinoin. Recent studies have controversial results about the necessity of laboratory investigation including hemogram and blood chemistry of patients during the follow up periodon isotretinoin.We aimed to investigate the effects of isotretinoin on Neutrophil/lymhocyte ratio (NLR) a systemic inflammation marker and the other hemogram parameters. Material and methods: Sixty seven patients with moderate to severe acne vulgaris aged between 18 to 25, who were prescribed 0.5mg/kg isotretinoin, were included to the study. Patients’ hemogram parameters before treatment and at the third month of treatment were recorded on SPSS 20.0 programme retrospectively. The difference between two values <0.05 was considered as statistically significant. Results: There were 37 female and 30 male patients, with a mean age of 21.12±3.54 years. There were no differences between the two groups by means of white blood count, neutrophil, lymphocyte counts and NLR. Among the other parameters, there was a statistically significant increase in monocyte count whereas basophil, eosinophil, platelet counts and hematocrit values revealed no differences. Red blood cells, hemoglobin, mean corpuscular volume and plateletocrit values revealed a statistically significant decrease (p<0.01). Conclusion: Isotretinoin, which is used as a miracle drug and favorable treatment of acne, may cause changes in hemogram parameters. It may lead to decreased hemoglobin values and increase of monocyte count during treatment. Patients with prominent iron deficiency may require close monitorization. Besides the unchanged NLR values may support no inflammatory reactions occur during muticentered studies, evaluating these parameters with larger sample sizes are required. isotretinoin treatment. Obviously

Keywords

Isotretinoin, hemogram parameters, hemoglobulin, neutrophil/lymphocyte ratio monocyte, eosinophil

İSOTRETİNOİN TEDAVİSİNİN NÖTROFİL/LENFOSİT ORANI VE DİĞER HEMOGRAM PARAMETRELERİNE ETKİSİNİN DEĞERLENDİRİLMESİ

Abstract

Amaç: Akne vulgariste sıklıkla kullanılan
isotretinoin tedavisi sırasında pek çok farklı yan
etki gelişebildiği bildirilmektedir. Son zamanlarda
yapılan çalışmalarda isotretinoin kullanan hastaların
kontrollerinde biyokimya ve hemogram gibi
laboratuvar tetkiklerinin gerekliliği konusunda
tartışmalı görüşler bulunmaktadır. Bu çalışmada
isotretinoin tedavisi alan hastalarda sistemik
inflamatuvar durumu göstermede kullanılan
nötrofil/lenfosit oranı ve diğer hemogram
parametrelerindeki değişimi araştırmayı amaçladık.
Gereç ve yöntemler: İsotretinoin tedavisi kullanan,
18-25 yaş aralığında, orta ve şiddetli akne vulgarisi
olan 67 hasta çalışmaya dahil edildi. Retrospektif
olarak hastaların tedavi öncesi ve tedavinin 3.
ayından sonraki hemogram parametreleri SPSS
20.0 programına kaydedildi.

Bulgular: Yaş ortalaması 21.12 ± 3.54 olan
hastaların 37’si bayan, 30’u erkek idi. Hemogram
parametrelerinden beyaz küre, nötrofil sayısı,
lenfosit sayısı ve nötrofil / lenfosit oranında 2 değer
arasında istatistiksel olarak farklılık saptanmadı.
Diğer parametrelerden monosit düzeylerinde
istatistiksel olarak anlamlı bir artış saptanırken,
bazofil, eozinofil, platelet ve hemotokrit
düzeylerinde fark görülmedi. Kırmızı hücreler,
hemoglobin, kırmızı hücrelerin ortalama volumü ve
plateletokrit düzeyleri arasında istatistiksel olarak
anlamlı azalma gözlendi.
Sonuç: İsotretinoin tedavisi hemogram
parametrelerinde değişikliklere yol açabilir. İlaç
kullanım süresince özellikle hemoglobin
düşüklüğüne, monosit artışına neden olabilir.
Anemisiolan hastaları isotretinoin tedavisi
altındayken yakın takip etmek gerekebilir.
Buparametrelerin değerlendirildiği, çok sayıda
hastanın yer aldığı çok merkezli çalışmalara ihtiyaç
duyulmaktadır.

Keywords

Anahtar hemogram parametreleri, hemoglobin, monosit, nötrofil/lenfosit oranı kelimeler: Eozinofil, isotretinoin

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