Predicting Severe Preeclampsia Importance of Hemogram Inflammatory Markers

Year 2022, Volume: 13 Issue: 45, 86 - 96, 07.04.2022

Umut Kudret , Mustafa Doğan Özçil

https://doi.org/10.17944/mkutfd.1034264

Abstract

Objective: In our study, we evaluated the neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and monocyte/lymphocyte ratio (MLR) among the inflammation markers in the hemogram results of patients diagnosed with preeclampsia in pregnancy and compared the pregnant women with the possibility of developing mild, severe preeclampsia It is aimed to determine its place in predicting mild, severe preeclampsia.
Method: The demographic data and laboratory tests of 308 preeclampsia and 308 healthy normotensive pregnant cases, 148 severe preeclampsia, 160 mild preeclampsia, were evaluated retrospectively. Groups were examined in terms of NLR, PLR and MLR.
Results: There was no difference for age between the groups. In the preeclampsia group, parity, gestational age, birth weight and APGAR scores were lower than the control group (p<0.001). The NLR was found to be significantly higher (p<0.001) and PLR was significantly lower in the preeclampsia group compared to the control group (p<0.001). There was no significant difference between the groups in MLR.
Conclusion: NLR and PLR can be used as a parameter to show the presence of preeclampsia. There was no statistically significant result for MLR.

Keywords

Pregnancy, Preeclampsia, Nötrophil, Lenphocyte, Monocyte, İnflamation.

Project Number

yoktur

Ağır preeklampsiyi öngörmede hemogram inflamatuar belirteçlerin önemi

Abstract

Amaç: Çalışmamızda, gebeliğinde preeklampsi tanısı alan hastaların hemogram sonuçlarındaki inflamasyon belirteçlerden nötrofil/lenfosit oranı (NLR), platelet/lenfosit oranı (PLR) ve monosit/lenfosit oranı (MLR) nın değerlendirilmesi ve hafif-ağır preeklampsi gelişme ihtimali olan gebeleri, normal gebelerle karşılaştırarak hafif-ağır preeklampsiyi öngörebilmedeki yerinin belirlenmesi amaçlanmıştır.
Yöntem: 148 ağır preeklampsili, 160 hafif preeklampsili olmak üzere toplam 308 preeklampsili ve 308 sağlıklı normotansif gebe olgusunun demografik verileri ve laboratuar testleri retrospektif olarak incelendi. Gruplar NLR, PLR ve MLR açısından incelendi.
Bulgular: Gruplar arasında yaş bakımından fark bulunmadı. Preeklampsi grubunda parite, gestasyonel yaş, doğum kilosu ve APGAR skorları kontrol grubuna kıyasla düşüktü (p<0.001). NLR preeklampsi grubunda kontrol grubuna kıyasla istatistiksel anlamlı derecede yüksek bulundu (p<0.001). PLR’ de anlamlı derecede düşük olarak bulundu (p<0.001). MLR de gruplar arasında anlamlı fark saptanmadı.
Sonuç: NLR ve PLR preeklampsi varlığının gösterilmesinde bir parametre olarak kullanılabilir. MLR için istatistiksel anlamlı sonuç saptanmadı.

Keywords

Gebelik, Preeklampsi, Nötrofil, Lenfosit, Monosit, İnflamasyon

Supporting Institution

yoktur

Project Number

yoktur

Thanks

Bu çalışmaya katkısı olan başta Anabilim Dalı Başkanımız Prof.Dr.Ali Ulvi Hakverdi olmak üzere tüm öğretim üyelerimize, İstatistik bölümünde bize yardımcı olan Dr.Öğretim Üyesi Memet Karadağa teşekkür ederiz.

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