Case Report
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Peripheral neuropathy as a rare syndrome related to metronidazole usage: Metronidazole may lead to persistent neuropathy

Year 2016, Volume: 3 Issue: 5, 239 - 41, 15.05.2016

Mehmet Aydin , Refah Sayin Mehmet Hamamci

https://doi.org/10.17546/msd.16987

Abstract

Metronidazole is a potent drug used against some protozoa like Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis and Balantidium coli, and anaerobic bacteria. It is used for the treatment of alcoholism, Crohn’s disease, exophthalmos, rheumatoid arthritis, rosea and acne as well. It is a well-tolerated drug with some kinds of side effects like abdominal pain, headache, nausea and metallic taste. Rarely but severely, pseudomembranous colitis, epileptic seizure, encephalopathy and peripheral neuropathy might be seen. These side effects are generally self-limited. Drug administration should be stopped immediately in case of these side effects’ existence. In this article, we presented a case which used metronidazole for hepatic ameobiasis in a time period of 4 and a half months, and developed peripheral neuropathy.

Keywords

Adverse effect; ameobiasis; metronidazole; peripheral neuropathy

References

  • Rustscheff S, Hulten S. An unexpected and severe neurological disorder with permanent disability acquired during short course treatment with metronidazole. Scand J Infect Dis 2003; 53:279-280.
  • Goodwin, D W, and Reinhard, J, Quarterly J'ournal of Studies of Alcohol. 1972, 33, 734.
  • Ozturk F, Burakgazi G, Akyol M. Metronidazole-induced encephalopathy in a patient with pons abscess: a case report. Abant Med J 2015; 4(3):293-294.
  • Park KI, Chung JM, Kim JY. Metronidazole neurotoxicity: sequential neuroaxis involvement. Neurol India. 2011; 59(1):104-107.
  • Cantador AA, Meschia JF, Freeman WD and Tatum WO. Nonconvulsive status with metronidazole. Neurohospitalist. 2013; 3(4):185-189.
  • Retamal-Riquelme E, Soto-San Martín H, Vallejos-Castro J, Galdames-Poblete D. Reversible neurotoxicity secondary to metronidazole: report of one case. RevMed Chil. 2014 Mar;142(3):386-390.
  • Heaney CJ, Campeau NG, and Lindell EP: MR imaging and diffusion-weighted imaging changes in metronidazole (Flagyl)-induced cerebellar toxicity, AJNR Am J Neuroradiol 2003; 24(8):1615-1617.
  • Boyce EG, Cookson ET, and Bond WS: Persistent metronidazole - induced peripheral neuropathy. DICP 1990; 24:19-21.
  • Takeuchi H, Yamada A, Touge T et al: Metronidazole neuropathy - a case report. Japanese Journal of Psychiatry and Neurology 1988; 42:291-295.
  • Bradley WG, Karlsson IJ, and Rassol CG: Metronidazole neuropathy, Br Med J 1977; 2(6087):610-611.
  • Pais P, Balasubramaniam KR: Metronidazole-peripheral neuropathy, J Assoc Physicians India 1982; 30(12):918-919.
  • Sarma GR, Kamath V: Acute painful peripheral neuropathy due to metronidazole, Neurol India 2005; 53(3):372-373.
  • Duffy LF, Daum F, Fisher SE et al: Peripheral neuropathy in Crohn’s disease patients treated with metronidazole, Gastroenterology 1985; 88(3):681-684.
  • Turan H, Horasanlı B, Şerefhanoğlu K, Ünler GK, Timurkaynak F, Arslan H: Peripheral Neuropathy Due to Metronidazole Treatment, ANKEM Derg 2007;21(2):98-100.

Year 2016, Volume: 3 Issue: 5, 239 - 41, 15.05.2016

Mehmet Aydin , Refah Sayin Mehmet Hamamci

https://doi.org/10.17546/msd.16987

Abstract

References

  • Rustscheff S, Hulten S. An unexpected and severe neurological disorder with permanent disability acquired during short course treatment with metronidazole. Scand J Infect Dis 2003; 53:279-280.
  • Goodwin, D W, and Reinhard, J, Quarterly J'ournal of Studies of Alcohol. 1972, 33, 734.
  • Ozturk F, Burakgazi G, Akyol M. Metronidazole-induced encephalopathy in a patient with pons abscess: a case report. Abant Med J 2015; 4(3):293-294.
  • Park KI, Chung JM, Kim JY. Metronidazole neurotoxicity: sequential neuroaxis involvement. Neurol India. 2011; 59(1):104-107.
  • Cantador AA, Meschia JF, Freeman WD and Tatum WO. Nonconvulsive status with metronidazole. Neurohospitalist. 2013; 3(4):185-189.
  • Retamal-Riquelme E, Soto-San Martín H, Vallejos-Castro J, Galdames-Poblete D. Reversible neurotoxicity secondary to metronidazole: report of one case. RevMed Chil. 2014 Mar;142(3):386-390.
  • Heaney CJ, Campeau NG, and Lindell EP: MR imaging and diffusion-weighted imaging changes in metronidazole (Flagyl)-induced cerebellar toxicity, AJNR Am J Neuroradiol 2003; 24(8):1615-1617.
  • Boyce EG, Cookson ET, and Bond WS: Persistent metronidazole - induced peripheral neuropathy. DICP 1990; 24:19-21.
  • Takeuchi H, Yamada A, Touge T et al: Metronidazole neuropathy - a case report. Japanese Journal of Psychiatry and Neurology 1988; 42:291-295.
  • Bradley WG, Karlsson IJ, and Rassol CG: Metronidazole neuropathy, Br Med J 1977; 2(6087):610-611.
  • Pais P, Balasubramaniam KR: Metronidazole-peripheral neuropathy, J Assoc Physicians India 1982; 30(12):918-919.
  • Sarma GR, Kamath V: Acute painful peripheral neuropathy due to metronidazole, Neurol India 2005; 53(3):372-373.
  • Duffy LF, Daum F, Fisher SE et al: Peripheral neuropathy in Crohn’s disease patients treated with metronidazole, Gastroenterology 1985; 88(3):681-684.
  • Turan H, Horasanlı B, Şerefhanoğlu K, Ünler GK, Timurkaynak F, Arslan H: Peripheral Neuropathy Due to Metronidazole Treatment, ANKEM Derg 2007;21(2):98-100.
There are 14 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Case Reports
Authors

Mehmet Aydin

Refah Sayin This is me

Mehmet Hamamci

Publication Date May 15, 2016
Published in Issue Year 2016 Volume: 3 Issue: 5

Cite

APA Aydin, M., Sayin, R., & Hamamci, M. (2016). Peripheral neuropathy as a rare syndrome related to metronidazole usage: Metronidazole may lead to persistent neuropathy. Medical Science and Discovery, 3(5), 239-41. https://doi.org/10.17546/msd.16987
AMA Aydin M, Sayin R, Hamamci M. Peripheral neuropathy as a rare syndrome related to metronidazole usage: Metronidazole may lead to persistent neuropathy. Med Sci Discov. May 2016;3(5):239-41. doi:10.17546/msd.16987
Chicago Aydin, Mehmet, Refah Sayin, and Mehmet Hamamci. “Peripheral Neuropathy As a Rare Syndrome Related to Metronidazole Usage: Metronidazole May Lead to Persistent Neuropathy”. Medical Science and Discovery 3, no. 5 (May 2016): 239-41. https://doi.org/10.17546/msd.16987.
EndNote Aydin M, Sayin R, Hamamci M (May 1, 2016) Peripheral neuropathy as a rare syndrome related to metronidazole usage: Metronidazole may lead to persistent neuropathy. Medical Science and Discovery 3 5 239–41.
IEEE M. Aydin, R. Sayin, and M. Hamamci, “Peripheral neuropathy as a rare syndrome related to metronidazole usage: Metronidazole may lead to persistent neuropathy”, Med Sci Discov, vol. 3, no. 5, pp. 239–41, 2016, doi: 10.17546/msd.16987.
ISNAD Aydin, Mehmet et al. “Peripheral Neuropathy As a Rare Syndrome Related to Metronidazole Usage: Metronidazole May Lead to Persistent Neuropathy”. Medical Science and Discovery 3/5 (May 2016), 239-41. https://doi.org/10.17546/msd.16987.
JAMA Aydin M, Sayin R, Hamamci M. Peripheral neuropathy as a rare syndrome related to metronidazole usage: Metronidazole may lead to persistent neuropathy. Med Sci Discov. 2016;3:239–41.
MLA Aydin, Mehmet et al. “Peripheral Neuropathy As a Rare Syndrome Related to Metronidazole Usage: Metronidazole May Lead to Persistent Neuropathy”. Medical Science and Discovery, vol. 3, no. 5, 2016, pp. 239-41, doi:10.17546/msd.16987.
Vancouver Aydin M, Sayin R, Hamamci M. Peripheral neuropathy as a rare syndrome related to metronidazole usage: Metronidazole may lead to persistent neuropathy. Med Sci Discov. 2016;3(5):239-41.
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