Effects of melatonin and agomelatine on doxorubicin induced anxiety and depression-like behaviors in rats

Year 2018, Volume: 5 Issue: 7, 253 - 259, 30.07.2018

Hatice Aygun , Serdar Savas Gul

https://doi.org/10.17546/msd.433289

Cited By: 1

Abstract

Objective:  Doxorubicin (DOX) is a
chemotherapeutic agent used to treat several cancer types; however, it
exhibits severe side effects in the nervous system which DOX treatment evoked
neurobehavioral alterations such as anxiety and depressive-like behavior. We
investigated the use of melatonin and agomelatine to prevent neurobehavioral
alterations caused by DOX.

Material and Methods: Forty-nine Wistar albino rats were
randomly divided into 7 groups, namely control (CON, n=7), doxorubicin (DOX,
n=7), melatonin (MEL, n=7), agomelatine (AGO, n=7), melatonin + doxorubicin
(MEL + DOX, n=7), agomelatine + doxorubicin (AGO + DOX, n=7) melatonin +
agomelatine + doxorubicin (MEL + AGO + DOX, n=7) groups. Doxorubicin (18 mg/kg)
was injected intraperitoneally (i.p) on the 5th, 6th, 7th day of the study.
Animals were treated with melatonin (40 mg/kg/i.p), agomelatine (40
mg/kg/i.p), melatonin (40 mg/kg/i.p) + agomelatine (40 mg/kg/i.p), for 7 days
and then doxorubicin (18 mg/kg/i.p) was injected on the 5th, 6th, 7th day. On
the 8th day of the experiment, all animal evaluated open field test (OFT) and
forced swim test (FST) respectively.

Results: The only DOX-treated rats exhibited the reduced
exploration, grooming, and locomotor activity in the open field test and
increased immobility time, reduced swimming time. Our data showed that the
rats treated with DOX exhibited anxiety and depressive-like behavior.
Melatonin and agomelatine treatment reduced all the parameters of DOX-induced
anxiety and depressive-like behavior in rats.

Conclusions: Melatonin and agomelatine have a protective
effect of against DOX-induced neurobehavioral alterations in rats.

Keywords

: doxorubicin, melatonin, agomelatine, rat, anxiety, depression

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