Injectable platelet-rich fibrin: a new material in medicine and dentistry
Year 2020,
, 27 - 33, 30.06.2020
Zeliha Betül Özsağır
,
Mustafa Tunalı
Abstract
Blood concentrates have been used in medicine and dentistry for many years as a wide variety of products. However, injectable platelet-rich fibrin (i-PRF), an autogenous blood concentrate found three years ago, is noteworthy. It is not difficult to predict that this completely autogenous blood concentrate, which can be used with minimally invasive methods and has many indications, will be used very widely in the future.
References
- 1. Kingsley CS. Blood coagulation; evidence of an antagonist to factor VI in platelet-rich human plasma. Nature 1954;173:723-4.
- 2. Anfossi G, Trovati M, Mularoni E, Massucco P, Calcamuggi G, Emanuelli G. Influence of propranolol on platelet aggregation and thromboxane B2 production from platelet-rich plasma and whole blood. Prostaglandins, leukotrienes and essential fatty acids 1989;36:1-7.
- 3. Fijnheer R, Pietersz R, De Korte D, et al. Platelet activation during preparation of platelet concentrates: a comparison of the platelet-rich plasma and the buffy coat methods. Transfusion 1990;30:634-8.
- 4. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;85:638-46.
- 5. Borzini P, Balbo V, Mazzucco L. Platelet concentrates for topical use: bedside device and blood transfusion technology. Quality and versatility. Curr Pharm Biotechnol 2012; 13:1138-44.
- 6. Jameson CA. Autologous platelet concentrate for the production of platelet gel. Laboratory Medicine 2007;38:39-42.
- 7. Marx RE. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg 2004;62:489-96.
- 8. Reinke JM, Sorg H. Wound repair and regeneration. Eur Surg Res 2012;49:35-43.
- 9. Freire MO, Van Dyke TE. Natural resolution of inflammation. Periodontology 2000 2013;63:149-64.
- 10. Kasnak G, Tunali M, Firatli HE. Geçmişten günümüze kan kaynaklı ürünler ve trombositten zengin fibrinler. Turkiye Klinikleri J Periodontol-Special Topics 2017;3:109-12.
- 11. Dohan DM, Choukroun J, Diss A, et al. Plateletrich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e37-e44.
- 12. Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte and platelet-rich fibrin (L-PRF). Trends Biotechnol 2009;27:158-67.
- 13. Dohan Ehrenfest DM, Del Corso M, Diss A, Mouhyi J, Charrier J-B. Three-dimensional architecture and cell composition of a Choukroun’s platelet rich fibrin clot and membrane. J Periodontol 2010;81:546-55.
- 14. Choukroun J, Diss A, Simonpieri A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e56-60.
- 15. O’Connell SM. Safety issues associated with platelet-rich fibrin method. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;103:587.
- 16. Tunali M, Ozdemir H, Kucukodaci Z, Akman S, Firatli E. In vivo evaluation of titanium-prepared platelet-rich fibrin (T-PRF): a new platelet concentrate. Br J Oral Maxillofac Surg 2013;51:438-43.
- 17. Tunali M, Ozdemir H, Kucukodaci Z, et al. A novel platelet concentrate for guided bone regeneration: Titanium prepared platelet-rich fibrin (T-PRF). Gulhane Med J 2015; 57:102-6.
- 18. Ghanaati S, Booms P, Orlowska A, et al. Advanced platelet-rich fibrin: a new concept for cell-based tissue engineering by means of inflammatory cells. J Oral Implantol 2014;40:679-89.
- 19. El Bagdadi K, Kubesch A, Yu X, et al. Reduction of relative centrifugal forces increases growth factor release within solid platelet-rich-fibrin (PRF)-based matrices: a proof of concept of LSCC (low speed centrifugation concept). Eur J Trauma Emerg Surg 2017:1-13.
- 20. Choukroun J, Ghanaati S. Reduction of relative centrifugation force within injectable platelet-rich fibrin (PRF) concentrates advances patients’ own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept. Eur J Trauma Emerg Surg 2018;44:87-95.
- 21. Peck M, Hiss D, Stephen L. Factors affecting the preparation, constituents, and clinical efficacy of leukocyte-and platelet-rich fibrin (L-PRF). SADJ 2016;71:298-302.
- 22. Tunali M, Ozdemir H, Kucukodaci Z, et al. A novel platelet concentrate: titanium-prepared platelet rich fibrin. Biomed Res Int 2014;2014:209548.
- 23. Wend S, Kubesch A, Orlowska A, et al. Reduction of the relative centrifugal force influences cell number and growth factor release within injectable PRF-based matrices. J Mater Sci Mater Med 2017;28:188.
- 24. Miron RJ, Fujioka-Kobayashi M, Hernandez M, et al. Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry? Clin Oral Investig 2017;21:2619-27.
- 25. Wang X, Zhang Y, Choukroun J, Ghanaati S, Miron RJ. Behavior of gingival fibroblasts on titanium implant surfaces in combination with either Injectable-PRF or PRP. Int J Mol Sci 2017;18:331.
- 26. Abd El Raouf M, Wang X, Miusi S, et al. Injectable-platelet rich fibrin using the low speed centrifugation concept improves cartilage regeneration when compared to platelet-rich plasma. Platelets 2019;30:213-21.
- 27. Karde PA, Sethi KS, Mahale SA, Khedkar SU, Patil AG, Joshi CP. Comparative evaluation of platelet count and antimicrobial efficacy of injectable platelet-rich fibrin with other platelet concentrates: An in vitro study. J Indian Soc Periodontol 2017;21:97-101.
- 28. Wang X, Zhang Y, Choukroun J, Ghanaati S, Miron RJ. Effects of an injectable platelet-rich fibrin on osteoblast behavior and bone tissue formation in comparison to platelet-rich plasma. Platelets 2018;29:48-55.
- 29. Varela HA, Souza JCM, Nascimento RM, et al. Injectable platelet rich fibrin: cell content, morphological, and protein characterization. Clin Oral Investig 2019;23:1309-18.
- 30. Albilia JB, Vizcaino CH, Weisleder H, Choukroun J, Ghanaati S. Liquid platelet-rich fibrin injections as a treatment adjunct for painful temporomandibular joints: preliminary results. Cranio 2018:1-13.
- 31. Kour P, Pudakalkatti PS, Vas AM, Das S, Padmanabhan S. Comparative evaluation of antimicrobial efficacy of platelet-rich plasma, platelet-rich fibrin, and injectable platelet-rich fibrin on the standard strains of porphyromonas gingivalis and aggregatibacter actinomycetemcomitans. Contemp Clin Dent 2018;9:325-30.
- 32. Tunali M, Ozsagir ZB, Unver T, Saglam E, Alinca SB, Toprak A. A new treatment approach for patients with oral lichen planus; I-PRF. J Clin Periodontol 2018;45:84-5.
- 33. Gode S, Ozturk A, Berber V, Kismali E. Effect of injectable platelet-rich fibrin on diced cartilage’s viability in rhinoplasty. Facial Plast Surg 2019;35:393-6.
- 34. Xie H, Xie YF, Liu Q, Shang LY, Chen MZ. Bone regeneration effect of injectable-platelet rich fibrin (I-PRF) in lateral sinus lift: a pilot study. Shanghai Kou Qiang Yi Xue 2019;28:71-5.
- 35. Ucak Turer O, Ozcan M, Alkaya B, Surmeli S, Seydaoglu G, Haytac MC. Clinical evaluation of injectable platelet rich fibrin with connective tissue graft for the treatment of deep gingival recession defects: A controlled randomized clinical trial. J Clin Periodontol 2020;47:72-80.
- 36. Ozsagir ZB, Saglam E, Sen Yilmaz B, Choukroun J, Tunali M. Injectable platelet-rich fibrin and microneedling for gingival augmentation in thin periodontal phenotype: A randomized controlled clinical trial. J Clin Periodontol 2020;47:489-99.
- 37. Jain NK, Gulati M. Platelet-rich plasma: a healing virtuoso. Blood Res 2016;51:3-5.
- 38. Maria-Angeliki G, Alexandros-Efstratios K, Dimitris R, Konstantinos K. Platelet-rich plasma as a potential treatment for noncicatricial alopecias. Int J Trichology 2015;7:54-63.
Enjekte edilebilen trombositten zengin fibrin: Tıpta ve diş hekimliğinde yeni bir materyal
Year 2020,
, 27 - 33, 30.06.2020
Zeliha Betül Özsağır
,
Mustafa Tunalı
Abstract
Kan konsantreleri tıpta ve diş hekimliğinde uzun yıllardır çok çeşitli ürünler olarak kullanılmaktadır. Buna rağmen, üç yıl önce bulunan bir otojen kan konsantresi olan enjekte edilebilen trombositten zengin fibrin (i-PRF) dikkati çekmektedir. Minimal invazif yöntemlerle kullanılabilen ve şimdiden birçok endikasyonu olan bu tamamen otojen kan konsantresinin gelecekte çok yaygın kullanılacağını tahmin etmek güç değil.
References
- 1. Kingsley CS. Blood coagulation; evidence of an antagonist to factor VI in platelet-rich human plasma. Nature 1954;173:723-4.
- 2. Anfossi G, Trovati M, Mularoni E, Massucco P, Calcamuggi G, Emanuelli G. Influence of propranolol on platelet aggregation and thromboxane B2 production from platelet-rich plasma and whole blood. Prostaglandins, leukotrienes and essential fatty acids 1989;36:1-7.
- 3. Fijnheer R, Pietersz R, De Korte D, et al. Platelet activation during preparation of platelet concentrates: a comparison of the platelet-rich plasma and the buffy coat methods. Transfusion 1990;30:634-8.
- 4. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;85:638-46.
- 5. Borzini P, Balbo V, Mazzucco L. Platelet concentrates for topical use: bedside device and blood transfusion technology. Quality and versatility. Curr Pharm Biotechnol 2012; 13:1138-44.
- 6. Jameson CA. Autologous platelet concentrate for the production of platelet gel. Laboratory Medicine 2007;38:39-42.
- 7. Marx RE. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg 2004;62:489-96.
- 8. Reinke JM, Sorg H. Wound repair and regeneration. Eur Surg Res 2012;49:35-43.
- 9. Freire MO, Van Dyke TE. Natural resolution of inflammation. Periodontology 2000 2013;63:149-64.
- 10. Kasnak G, Tunali M, Firatli HE. Geçmişten günümüze kan kaynaklı ürünler ve trombositten zengin fibrinler. Turkiye Klinikleri J Periodontol-Special Topics 2017;3:109-12.
- 11. Dohan DM, Choukroun J, Diss A, et al. Plateletrich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e37-e44.
- 12. Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte and platelet-rich fibrin (L-PRF). Trends Biotechnol 2009;27:158-67.
- 13. Dohan Ehrenfest DM, Del Corso M, Diss A, Mouhyi J, Charrier J-B. Three-dimensional architecture and cell composition of a Choukroun’s platelet rich fibrin clot and membrane. J Periodontol 2010;81:546-55.
- 14. Choukroun J, Diss A, Simonpieri A, et al. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:e56-60.
- 15. O’Connell SM. Safety issues associated with platelet-rich fibrin method. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;103:587.
- 16. Tunali M, Ozdemir H, Kucukodaci Z, Akman S, Firatli E. In vivo evaluation of titanium-prepared platelet-rich fibrin (T-PRF): a new platelet concentrate. Br J Oral Maxillofac Surg 2013;51:438-43.
- 17. Tunali M, Ozdemir H, Kucukodaci Z, et al. A novel platelet concentrate for guided bone regeneration: Titanium prepared platelet-rich fibrin (T-PRF). Gulhane Med J 2015; 57:102-6.
- 18. Ghanaati S, Booms P, Orlowska A, et al. Advanced platelet-rich fibrin: a new concept for cell-based tissue engineering by means of inflammatory cells. J Oral Implantol 2014;40:679-89.
- 19. El Bagdadi K, Kubesch A, Yu X, et al. Reduction of relative centrifugal forces increases growth factor release within solid platelet-rich-fibrin (PRF)-based matrices: a proof of concept of LSCC (low speed centrifugation concept). Eur J Trauma Emerg Surg 2017:1-13.
- 20. Choukroun J, Ghanaati S. Reduction of relative centrifugation force within injectable platelet-rich fibrin (PRF) concentrates advances patients’ own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept. Eur J Trauma Emerg Surg 2018;44:87-95.
- 21. Peck M, Hiss D, Stephen L. Factors affecting the preparation, constituents, and clinical efficacy of leukocyte-and platelet-rich fibrin (L-PRF). SADJ 2016;71:298-302.
- 22. Tunali M, Ozdemir H, Kucukodaci Z, et al. A novel platelet concentrate: titanium-prepared platelet rich fibrin. Biomed Res Int 2014;2014:209548.
- 23. Wend S, Kubesch A, Orlowska A, et al. Reduction of the relative centrifugal force influences cell number and growth factor release within injectable PRF-based matrices. J Mater Sci Mater Med 2017;28:188.
- 24. Miron RJ, Fujioka-Kobayashi M, Hernandez M, et al. Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry? Clin Oral Investig 2017;21:2619-27.
- 25. Wang X, Zhang Y, Choukroun J, Ghanaati S, Miron RJ. Behavior of gingival fibroblasts on titanium implant surfaces in combination with either Injectable-PRF or PRP. Int J Mol Sci 2017;18:331.
- 26. Abd El Raouf M, Wang X, Miusi S, et al. Injectable-platelet rich fibrin using the low speed centrifugation concept improves cartilage regeneration when compared to platelet-rich plasma. Platelets 2019;30:213-21.
- 27. Karde PA, Sethi KS, Mahale SA, Khedkar SU, Patil AG, Joshi CP. Comparative evaluation of platelet count and antimicrobial efficacy of injectable platelet-rich fibrin with other platelet concentrates: An in vitro study. J Indian Soc Periodontol 2017;21:97-101.
- 28. Wang X, Zhang Y, Choukroun J, Ghanaati S, Miron RJ. Effects of an injectable platelet-rich fibrin on osteoblast behavior and bone tissue formation in comparison to platelet-rich plasma. Platelets 2018;29:48-55.
- 29. Varela HA, Souza JCM, Nascimento RM, et al. Injectable platelet rich fibrin: cell content, morphological, and protein characterization. Clin Oral Investig 2019;23:1309-18.
- 30. Albilia JB, Vizcaino CH, Weisleder H, Choukroun J, Ghanaati S. Liquid platelet-rich fibrin injections as a treatment adjunct for painful temporomandibular joints: preliminary results. Cranio 2018:1-13.
- 31. Kour P, Pudakalkatti PS, Vas AM, Das S, Padmanabhan S. Comparative evaluation of antimicrobial efficacy of platelet-rich plasma, platelet-rich fibrin, and injectable platelet-rich fibrin on the standard strains of porphyromonas gingivalis and aggregatibacter actinomycetemcomitans. Contemp Clin Dent 2018;9:325-30.
- 32. Tunali M, Ozsagir ZB, Unver T, Saglam E, Alinca SB, Toprak A. A new treatment approach for patients with oral lichen planus; I-PRF. J Clin Periodontol 2018;45:84-5.
- 33. Gode S, Ozturk A, Berber V, Kismali E. Effect of injectable platelet-rich fibrin on diced cartilage’s viability in rhinoplasty. Facial Plast Surg 2019;35:393-6.
- 34. Xie H, Xie YF, Liu Q, Shang LY, Chen MZ. Bone regeneration effect of injectable-platelet rich fibrin (I-PRF) in lateral sinus lift: a pilot study. Shanghai Kou Qiang Yi Xue 2019;28:71-5.
- 35. Ucak Turer O, Ozcan M, Alkaya B, Surmeli S, Seydaoglu G, Haytac MC. Clinical evaluation of injectable platelet rich fibrin with connective tissue graft for the treatment of deep gingival recession defects: A controlled randomized clinical trial. J Clin Periodontol 2020;47:72-80.
- 36. Ozsagir ZB, Saglam E, Sen Yilmaz B, Choukroun J, Tunali M. Injectable platelet-rich fibrin and microneedling for gingival augmentation in thin periodontal phenotype: A randomized controlled clinical trial. J Clin Periodontol 2020;47:489-99.
- 37. Jain NK, Gulati M. Platelet-rich plasma: a healing virtuoso. Blood Res 2016;51:3-5.
- 38. Maria-Angeliki G, Alexandros-Efstratios K, Dimitris R, Konstantinos K. Platelet-rich plasma as a potential treatment for noncicatricial alopecias. Int J Trichology 2015;7:54-63.