Retrospective evaluation of 106 Behçet’s disease patients in Giresun province

Year 2020, Volume: 3 Issue: 1, 12 - 17, 31.03.2020

Burak Akşan , Sevgi Kulaklı , Işıl Deniz Oğuz

https://doi.org/10.33204/mucosa.654798

Abstract

Background Behçet’s disease (BD) is a multisystem inflammatory disorder which is an important cause of morbidity in Turkey.

Objective We aimed to investigate the demographical and clinical features of patients with BD followed up in our department in Faculty of Medicine in Giresun University Training and Research Hospital.

Methods The hospital records of patients with BD who attended the dermatology department between 2006-2019 were retrospectively evaluated. One hundred and six patients who met the diagnostic criteria of International Study Group for BD were included in the study. The clinical and demographic characteristics, including the age of onset, disease duration, mucocutaneous findings and systemic involvements were recorded.

Results Of the 106 patients in the study, 64 (60.4%) were female, 42 (39.6%) were male, and the female-to-male ratio was 1.52:1. The median age at the onset of the disease was 38 years, and the median disease duration was 9 years (range 1-40 years). The most common finding was recurrent oral ulcers (100%) followed by genital ulcers (86.6%), ocular involvement (52.8%), erythema nodosum (49.1%), articular involvement (45.3%), papulopustular lesions (34%), positive pathergy test (21.7%), vascular involvement (14.2%), gastrointestinal involvement (9.4%), neurologic (2.8%) and genitourinary involvement (2.8%). Papulopustular lesions were seen statistically significantly more frequent in men (P=0.047).

Conclusion In our study, we presented the demographical and clinical features of patients with BD in a single center in Giresun. Major findings were mucocutaneous ones and most common extracutaneous involvements were eyes and joints.

Keywords

Behçet’s disease, epidemiology, demographical characteristics, turkey

Giresun ilindeki 106 Behçet hastasının retrospektif değerlendirilmesi

Abstract

Amaç Behçet hastalığı (BH) Türkiye’de önemli morbiditelere neden olan, multisistemik inflamatuvar bir hastalıktır. Bu çalışmada Giresun Üniversitesi Tıp Fakültesi Eğitim ve Araştırma Hastanesi dermatoloji kliniğinde BH tanısı ile takip edilen hastaların demografik ve klinik özelliklerinin belirlenmesi amaçlandı.

Yöntem 2006-2019 yılları arasında hastanemiz dermatoloji kliniğinde BH tanısı ile izlenen hastaların kayıtları geriye dönük olarak incelendi. Uluslararası Behçet hastalığı Çalışma Grubu’nun tanı kriterlerini karşılayan toplam 106 hasta çalışmaya dâhil edildi. Başlangıç yaşı, hastalık süresi, mukokütanöz bulgular ve sistemik tutulumlar dâhil olmak üzere klinik ve demografik özellikler kaydedildi.

Bulgular Çalışmaya alınan 106 hastanın 64’ü kadın (%60.4), 42’si erkekti (%39.6). Kadın/erkek oranı 1.52:1 idi. Ortalama başlangıç yaş ortancası 38 yaş, hastalık süresi ortancası 9 yıl (1-40) olarak saptandı. En sık görülen klinik bulgu tekrarlayan oral ülserlerdi, hastaların tamamında mevcuttu. Oral ülserleri sırasıyla genital ülser (%81.1), göz tutulumu (%52.8), eritema nodozum (%49.1), eklem tutulumu (%45.3), papülopüstüler lezyonlar (%34), pozitif paterji testi (%21.7), damar tutulumu (%14.2), gastrointestinal tutulum (%9.4), nörolojik (%2.8) ve genitoüriner tutulum (%2.8) takip etmekteydi. Erkeklerde papülopüstüler lezyon sıklığı kadınlara göre anlamlı oranda daha yüksek saptandı (P=0.047).

Sonuç Çalışmamızda Giresun’da tek merkezli olarak takip edilen Behçet hastalarının demografik ve klinik verileri sunuldu. Mukokütanöz bulguların ön planda olduğu hastalarda göz ve eklem en sık tutulan deri dışı organlar olarak saptandı.

Keywords

Behçet hastalığı, demografik özellikler, epidemiyoloji, Türkiye

References

• 1. Tuzun Y, Fresko I, Mat MC, et al. Behçet Sendromu. In: Dermatoloji, 3rd ed. İstanbul, Nobel Tıp Kitabevleri 2008;913-28.
• 2. Sallakci N, Bacanli A, Coskun M, Yavuzer U, Alpsoy E, Yegin O. CTLA-4 gene 49A/G polymorphism in Turkish patients with Behcet’s disease. Clin Exp Dermatol 2005;30:546-50.
• 3. Alpsoy E, Zouboulis CC, Ehrlich CE. Mucocutaneous lesions of Behcet’s disease. Yonsei Med J 2007;48:573-85.
• 4. Azizlerli G, Kose AA, Sarica R et al. Prevalence of Behcet’s disease in Istanbul, Turkey. Int J Dermatol 2003;42:803-6.
• 5. Sakane T, Takeno M, Suzuki N, Inaba G. Behcet’s disease. N Engl J Med 1999;341:1284-91.
• 6. Cho SB, Cho S, Bang D. New insights in the clinical understanding of Behcet’s disease. Yonsei Med J 2012; 53:35-42.
• 7. Yurdakul S, Hamuryudan V, Yazıcı H. Behçet syndrome. Curr Op Rheum 2004;16:38-42.
• 8. International study group for Behçet’s disease. Criteria for diagnosis of Behçet’s disease. Lancet 1990;335:1078-80.
• 9. Onder M, Gurer MA. Behçet’s disease: an enigmatic vasculitis. Clin Dermatol 1999;42:803-6.
• 10. Verity DH, Marr JE, Ohno S, Wallace GR, Stanford MR. Behçet’s disease, the Silk Road and HLA-B51: historical and geographical perspectives. Tissue Antigens 1999;54:213-20.
• 11. Hegab S, Mutava S. Immunopathogenesis of Behçet’s disease. Clin Immunol 2000;42:803-6.
• 12. Bang DS, Oh SH, Lee KH, Lee ES, Lee SN. Influence of sex on patients with Behçet’s disease in Korea. J Korean Med Sci 2003;18:231-5.
• 13. Teter MS, Hochberg MC. Diagnostic criteria and epidemiology. In: Plotkin GR, Calabro JJ, O’Duffy JD, editors, Behçet’s disease: A contemporary synopsis. New York Futura Publishing 1988;9-21.
• 14. Karincaoglu Y, Coskun BK, Seyhan M, Aki T. Demographical and clinical characteristics of Behçet’s disease patients in Malatya and Elazig. Turkiye Klinikleri J Dermatol 2005;15:65-70.
• 15. Gurler A, Boyvat A, Tursen U. Clinical manifestations of Behcet’s disease: an analysis of 2147 patients. Yonsei Med J 1997;38:423-7.
• 16. Alpsoy E, Donmez L, Bacanli A, Apaydin C, Butun B. Review of the chronology of clinical manifestations in 60 patients with Behçet’s disease. Dermatology 2003;207:354-6.
• 17. Tursen U, Gurler A, Boyvat A. Evaluation of clinical findings according to sex in 2313 Turkish patients with Behçet’s disease. Int J Dermatol 2003;42:346-51.
• 18. Yazici H, Tuzun Y, Pazarli H, et al. Influence of age of oncet and patient’s sex on the prevalence and severity of manifestations of Behçet’s syndrome. Ann Rheum Dis 1984;43:783-9.
• 19. Madanat W, Fayyad F, Verity D, Zureikat H. Influence of sex on Behçet’s disease. In: Bang D, Lee ES, Lee S, editors, Behçet’s disease: Proceeding of the 8th and 9th International Conference on Behçet’s disease. Seol: Design Mecca Publishing 2001;90-3.
• 20. Uslu M, Karaman G, Savk E, Şendur N, Yılmaz E Aydın’da Behçet hastalığı deneyimi:67 hastanın retrospektif değerlendirilmesi. ADU Tıp Fakultesi Dergisi 2008;9:21-6.
• 21. Dogan B, Taskapan O, Harmanyeri Y. Prevalance of pathergy test positivity in Behçet’s disease in Turkey. J Eur Acad Dermatol Venereol 2003;17:228-9.
• 22. Karabacak E, Aydin E, Dogan B, et al. Behçet hastalığı: 182 hastanın klinik ve demografik özellikleri Turkderm 2014;48:121-6.
• 23. Ozyazgan Y. Behçet Hastalığında Göz Tutulumu. Turkderm 2009;43:48-53.
• 24. Zouboulis CC, Kotter I, Djawari D, et al. Epidemiological features of Adamantiades-Behçet’s disease in Germany and in Europe. Yonsei Med J 1997;38:411-22.
• 25. Saylan T, Mat C, Fresko I, Melikoglu M. Behçet’s disease in Middle East. Clin Dermatol 1999;17:209-23.
• 26. Can M, Direskeneli H: Behçet hastalığında kas, iskelet sistemi ve damar tutulumu. Turkderm 2009;43 Özel Sayı:54-60.
• 27. Cheng TK, Thong BY, Chng HH. Behçet’s disease: experience in a tertiary rheumatology center in Singapore and a review of the literature. Ann Acad Med Singapore 2004;33:510-4.
• 28. Seaman G, Pearce RA. Behcet’s Disease manifestation in a population drawn from the UK Behcet’s Syndrome Society. Behcet’s Disease. Ed. Hamza M. Tunisia, Pub Adhoua 1997;196-9.
• 29. Al-Araji A, Sharquie K, Al-Rawi Z. Prevalence and pattern of neurological involvement in Behcet’s disease: a prospective study from Iraq. J Neurol Neurosurg Psychiatry 2003;7:608-13.
• 30. Akman-Demir G. Behçet Hastalığında Nörolojik Tutulum. Turkderm 2009;43 Özel Sayı:61-4.
• 31. Davatchi F, Shahram F, Chams C, Chams H, Nadji A. Behçet’s disease. Acta Medica Iranica 2005;43:233-42.
• 32. Pipitone N, Boiardi L, Olivieri I, et al: Clinical manifestations of Behçet’s disease in 137 Italian patients: results of a multicenter study. Clin Exp Rheumatol 2004;22:46-5