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The Presence of Dry Eye Syndrome in Patients with Fibromyalgia: A Cross-sectional Controlled Study

Year 2021, Volume: 8 Issue: 3, 184 - 188, 28.12.2021
https://doi.org/10.47572/muskutd.786962

Abstract

Our aim is to investigate the presence of dry eye in fibromyalgia (FM) patients with using a self-reported questionnaire and objective tests. This study included 20 patients who were newly diagnosed FM and 20 healthy controls. Both groups were evaluated with ocular surface disease scale (OSDI), non-anesthetized Schirmer-I test, meibography, tear meniscus assessment, fluorescein tear break time (FBUT), non-invasive tear break time (NITBUT) and corneal fluorescein staining (CFS) tests. OSDI questions were significantly higher, FBUT values were significantly lower and FBUT values were significantly correlated with OSDI in FM patients. (p<0.05, p=0.007). There was no significant difference in other parameters.
In this context, it was observed in this study that FM patients had significantly more ocular discomfort than healthy controls. Early recognition of comorbidities by physicians ensures the success of FM treatment with comorbidities.

References

  • 1. Bucourt E, Martaillé V, Goupille P, et al. A Comparative Study of Fibromyalgia, Rheumatoid Arthritis, Spondyloarthritis, and Sjögren's Syndrome; Impact of the Disease on Quality of Life, Psychological Adjustment, and Use of Coping Strategies. Pain med. 2019:20(2):255.
  • 2. Bazzichi L, Giacomelli C, Consensi A, et al. One year in review 2016: fibromyalgia. Clin Exp Rheumatol. 2016;34(2):145-9.
  • 3. Cavalcante AB, Sauer JF, Chalot SD, et al. The prevalence of fibromyalgia: a literature review. Rev Bras de Reumatol. 2006;46(1):40–8.
  • 4. Wolfe F, Clauw D, Fitzcharles M, et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res. 2010;62(5):600–10.
  • 5. Shimazaki J, Seika D, Saga M, et al. A prospective, randomized trial of two mucin secretogogues for the treatment of dry eye syndrome in office workers. Sci Rep. 2017;7(1):15210.
  • 6. Ulusoy MO, Kal A. Ön Segment Optik Koherans Tomografi Kullanarak Farklı Romatolojik Hastalıklarda Kuru Göz Değerlendirmesi. MN Oftalmoloji 2017;24(4): 192-7.
  • 7. Stern ME, Schaumburg CS, Pflugfelder SC. Dry eye as a mucosal autoimmune disease. Int Rev Immunol. 2013;32(1):19-41.
  • 8. Kırağ N. Temel AB. Yaşlı Bireylerde Kuru Göz Semptomu Sıklığı ve İlişkili Faktörler. Anadolu Hemş Sağ Bil Derg. 2016;19(4):243-51.
  • 9. Utine CA. Kuru Göz Oluşum Mekanizması ve Sınıflandırılması. MN Oftalmoloji. 2016;23(11):1-8.
  • 10. Uchino M, Schaumberg DA. Dry eye disease: impact on quality of life and vision. Curr Ophthalmol Rep. 2013;1(2):51–7.
  • 11. Gallar J, Morales C, Freire V, et al. Decreased corneal sensitivity and tear production in fibromyalgia. Invest Ophthalmol Vis Sci. 2009;50(9):4129-34.
  • 12. Vehof J, Smitt-Kamminga NS, Kozareva D, et al. Hammond Clinical Characteristics of Dry Eye Patients With Chronic Pain Syndromes. Am J Ophthalmol. 2016;162(2):59-65.
  • 13. Karakoyun A, Yaşar E, Gürlevik U, et al. Fibromiyalji Hastalarında Göz Bulgularının Değerlendirilmesi. Turk J Osteoporos. 2019;25(1):19-22.
  • 14. Schuster AK, Wettstein M, Gerhardt A, et al. Eye pain and dry eye in patients with fibromyalgia. Pain Med. 2018;19(12):2528‐35.
  • 15. Türkyilmaz K, Türkyilmaz AK, Kurt EE, et al. Dry eye in patients with fibromyalgia and its relevance to functional and emotional status. Cornea. 2013;32(6):862-6.
  • 16. Chen CH, Yang TY, Lin CL, et al. Dry Eye Syndrome Risks in Patients With Fibromyalgia. Medicine. 2016;95(4):2607.
  • 17. Shimazaki J. Definition and diagnostic criteria of dry eye disease: historical overview and future directions. Invest Ophthalmol Vis Sci. 2018;59(1):7–12.
  • 18. Schiffman RM, Christianson MD, Jacobsen G, et al. Reliability and validity of the ocular surface disease index. Arch Ophthalmol. 2000;118(5):615–21.
  • 19. Benlidayi IC. Role of inflammation in the pathogenesis and treatment of fibromyalgia. Rheumatol Int. 2019;39(2):781–91.
  • 20. Turan KE, Kocabeyoglu S, Unal-Cevik I, et al. Ocular surface alterations in the context of corneal in vivo confocal microscopic characteristics in patients with fibromyalgia. Cornea. 2018;37(2):205‐10.
  • 21. Üçeyler N, Zeller D, Kahn AK et al. Small fibre pathology in patients with fibromyalgia syndrome. Brain. 2013;136(6):1857–67.
  • 22. Ramírez M, Martínez-Martínez LA, Hernández-Quintela E, et al. Small fiber neuropathy in women with fibromyalgia. An in vivo assessment using corneal confocal bio-microscopy. Semin Arthritis Rheum. 2015;45(2):214–9.
  • 23. Hoffman DL, Dukes EM. The health status burden of people with fibromyalgia: A review of studies RFBUT ile that assessed health status with the SF-36 or the SF-12. Int J Clin Pract. 2008;62(1):115–2.

Fibromiyalji Hastalarında Kuru Göz Sendromu Varlığı: Kesitsel Kontrollü Bir Çalışma

Year 2021, Volume: 8 Issue: 3, 184 - 188, 28.12.2021
https://doi.org/10.47572/muskutd.786962

Abstract

Amacımız birçok objektif testle fibromiyalji (FM) hastalarında kuru göz varlığını araştırmaktır. Bu çalışmaya yeni FM tanısı konmuş 20 hasta ve 20 sağlıklı kontrol dahil edildi. Her iki grup oküler yüzey hastalık indeksi (OSDI), anestezisiz Schirmer testi, meibografi, gözyaşı menisküs ölçümü, floresein gözyaşı kırılma süresi (FBUT), invaziv olmayan gözyaşı kırılma süresi (NBUT) ve korneal floresan boyama testleri (CFS) ile değerlendirildi. FM hastalarında OSDI skorları anlamlı olarak yüksek, FBUT değerleri anlamlı olarak düşük ve FBUT değerleri OSDI skorları korele idi (p<0.05, p=0.007). Diğer parametrelerde anlamlı bir fark yoktu. Bu çalışmada FM hastalarının sağlıklı kontrollerden önemli ölçüde daha fazla oküler rahatsızlığa sahip olduğu gözlenmiştir. Komorbiditelerin doktorlar tarafından erken tanınması, fibromiyalji tedavisinde daha etkin bir başarı sağlar. 

References

  • 1. Bucourt E, Martaillé V, Goupille P, et al. A Comparative Study of Fibromyalgia, Rheumatoid Arthritis, Spondyloarthritis, and Sjögren's Syndrome; Impact of the Disease on Quality of Life, Psychological Adjustment, and Use of Coping Strategies. Pain med. 2019:20(2):255.
  • 2. Bazzichi L, Giacomelli C, Consensi A, et al. One year in review 2016: fibromyalgia. Clin Exp Rheumatol. 2016;34(2):145-9.
  • 3. Cavalcante AB, Sauer JF, Chalot SD, et al. The prevalence of fibromyalgia: a literature review. Rev Bras de Reumatol. 2006;46(1):40–8.
  • 4. Wolfe F, Clauw D, Fitzcharles M, et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res. 2010;62(5):600–10.
  • 5. Shimazaki J, Seika D, Saga M, et al. A prospective, randomized trial of two mucin secretogogues for the treatment of dry eye syndrome in office workers. Sci Rep. 2017;7(1):15210.
  • 6. Ulusoy MO, Kal A. Ön Segment Optik Koherans Tomografi Kullanarak Farklı Romatolojik Hastalıklarda Kuru Göz Değerlendirmesi. MN Oftalmoloji 2017;24(4): 192-7.
  • 7. Stern ME, Schaumburg CS, Pflugfelder SC. Dry eye as a mucosal autoimmune disease. Int Rev Immunol. 2013;32(1):19-41.
  • 8. Kırağ N. Temel AB. Yaşlı Bireylerde Kuru Göz Semptomu Sıklığı ve İlişkili Faktörler. Anadolu Hemş Sağ Bil Derg. 2016;19(4):243-51.
  • 9. Utine CA. Kuru Göz Oluşum Mekanizması ve Sınıflandırılması. MN Oftalmoloji. 2016;23(11):1-8.
  • 10. Uchino M, Schaumberg DA. Dry eye disease: impact on quality of life and vision. Curr Ophthalmol Rep. 2013;1(2):51–7.
  • 11. Gallar J, Morales C, Freire V, et al. Decreased corneal sensitivity and tear production in fibromyalgia. Invest Ophthalmol Vis Sci. 2009;50(9):4129-34.
  • 12. Vehof J, Smitt-Kamminga NS, Kozareva D, et al. Hammond Clinical Characteristics of Dry Eye Patients With Chronic Pain Syndromes. Am J Ophthalmol. 2016;162(2):59-65.
  • 13. Karakoyun A, Yaşar E, Gürlevik U, et al. Fibromiyalji Hastalarında Göz Bulgularının Değerlendirilmesi. Turk J Osteoporos. 2019;25(1):19-22.
  • 14. Schuster AK, Wettstein M, Gerhardt A, et al. Eye pain and dry eye in patients with fibromyalgia. Pain Med. 2018;19(12):2528‐35.
  • 15. Türkyilmaz K, Türkyilmaz AK, Kurt EE, et al. Dry eye in patients with fibromyalgia and its relevance to functional and emotional status. Cornea. 2013;32(6):862-6.
  • 16. Chen CH, Yang TY, Lin CL, et al. Dry Eye Syndrome Risks in Patients With Fibromyalgia. Medicine. 2016;95(4):2607.
  • 17. Shimazaki J. Definition and diagnostic criteria of dry eye disease: historical overview and future directions. Invest Ophthalmol Vis Sci. 2018;59(1):7–12.
  • 18. Schiffman RM, Christianson MD, Jacobsen G, et al. Reliability and validity of the ocular surface disease index. Arch Ophthalmol. 2000;118(5):615–21.
  • 19. Benlidayi IC. Role of inflammation in the pathogenesis and treatment of fibromyalgia. Rheumatol Int. 2019;39(2):781–91.
  • 20. Turan KE, Kocabeyoglu S, Unal-Cevik I, et al. Ocular surface alterations in the context of corneal in vivo confocal microscopic characteristics in patients with fibromyalgia. Cornea. 2018;37(2):205‐10.
  • 21. Üçeyler N, Zeller D, Kahn AK et al. Small fibre pathology in patients with fibromyalgia syndrome. Brain. 2013;136(6):1857–67.
  • 22. Ramírez M, Martínez-Martínez LA, Hernández-Quintela E, et al. Small fiber neuropathy in women with fibromyalgia. An in vivo assessment using corneal confocal bio-microscopy. Semin Arthritis Rheum. 2015;45(2):214–9.
  • 23. Hoffman DL, Dukes EM. The health status burden of people with fibromyalgia: A review of studies RFBUT ile that assessed health status with the SF-36 or the SF-12. Int J Clin Pract. 2008;62(1):115–2.
There are 23 citations in total.

Details

Primary Language English
Subjects ​Internal Diseases
Journal Section Original Article
Authors

Nihal Tezel 0000-0002-7623-7827

Aysun Şanal Dogan 0000-0002-7401-8903

Ebru Umay 0000-0002-4137-7731

Canan Gürdal 0000-0003-3017-3853

Aytül Çakcı 0000-0002-4137-7731

Publication Date December 28, 2021
Submission Date August 28, 2020
Published in Issue Year 2021 Volume: 8 Issue: 3

Cite

APA Tezel, N., Şanal Dogan, A., Umay, E., Gürdal, C., et al. (2021). The Presence of Dry Eye Syndrome in Patients with Fibromyalgia: A Cross-sectional Controlled Study. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, 8(3), 184-188. https://doi.org/10.47572/muskutd.786962
AMA Tezel N, Şanal Dogan A, Umay E, Gürdal C, Çakcı A. The Presence of Dry Eye Syndrome in Patients with Fibromyalgia: A Cross-sectional Controlled Study. MMJ. December 2021;8(3):184-188. doi:10.47572/muskutd.786962
Chicago Tezel, Nihal, Aysun Şanal Dogan, Ebru Umay, Canan Gürdal, and Aytül Çakcı. “The Presence of Dry Eye Syndrome in Patients With Fibromyalgia: A Cross-Sectional Controlled Study”. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 8, no. 3 (December 2021): 184-88. https://doi.org/10.47572/muskutd.786962.
EndNote Tezel N, Şanal Dogan A, Umay E, Gürdal C, Çakcı A (December 1, 2021) The Presence of Dry Eye Syndrome in Patients with Fibromyalgia: A Cross-sectional Controlled Study. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 8 3 184–188.
IEEE N. Tezel, A. Şanal Dogan, E. Umay, C. Gürdal, and A. Çakcı, “The Presence of Dry Eye Syndrome in Patients with Fibromyalgia: A Cross-sectional Controlled Study”, MMJ, vol. 8, no. 3, pp. 184–188, 2021, doi: 10.47572/muskutd.786962.
ISNAD Tezel, Nihal et al. “The Presence of Dry Eye Syndrome in Patients With Fibromyalgia: A Cross-Sectional Controlled Study”. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 8/3 (December 2021), 184-188. https://doi.org/10.47572/muskutd.786962.
JAMA Tezel N, Şanal Dogan A, Umay E, Gürdal C, Çakcı A. The Presence of Dry Eye Syndrome in Patients with Fibromyalgia: A Cross-sectional Controlled Study. MMJ. 2021;8:184–188.
MLA Tezel, Nihal et al. “The Presence of Dry Eye Syndrome in Patients With Fibromyalgia: A Cross-Sectional Controlled Study”. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, vol. 8, no. 3, 2021, pp. 184-8, doi:10.47572/muskutd.786962.
Vancouver Tezel N, Şanal Dogan A, Umay E, Gürdal C, Çakcı A. The Presence of Dry Eye Syndrome in Patients with Fibromyalgia: A Cross-sectional Controlled Study. MMJ. 2021;8(3):184-8.