The Effects of Treatment on Hematological Parameters in the Patients with Acne Vulgaris

Year 2021, Volume: 8 Issue: 3, 204 - 206, 28.12.2021

Ercan Saruhan , Emine Tuğba Alataş

https://doi.org/10.47572/muskutd.872846

Abstract

Acne vulgaris is a multifactorial disease of the pilosebaceous unit. Various immunological and inflammatory factors play a role with different pathophysiological mechanisms in the development of acne vulgaris by increasing sebum production. The aim of this study was to reveal the changes in CBC sub-parameters and calculated parameters before and after acne vulgaris treatment and to enable these parameters to be used as non-invasive, low-cost, effective new laboratory tests in the evaluation of treatment efficacy. A total of 162 patients (109 females, 67.3%; 53 males, 32.7%) were included in this study. In this study, it was found that NEU, MPV, P-LCR, and PDW levels decreased significantly after treatment (p<0.001). There was a significant decrease in NLR and PLR values (p<0.001). LYM and PLT count increased significantly after the treatment (p<0.001). CBC parameters such as NLR, PLR, and P-LCR can be used to evaluate the efficacy of systemic isotretinoin treatment in patients with acne vulgaris. 

Keywords

Acne Vulgaris, Inflammation, Neutrophil to Lymphocyte Ratio, Platelet

Akne Vulgaris Hastalarında Tedavinin Hematolojik Parametreler Üzerine Etkisi

Abstract

Akne vulgaris pilosebase ünitenin multifaktöriyel inflamatuvar hastalığıdır. Akne vulgaris gelişiminde çeşitli immünolojik ve inflamatuar faktörler farklı patofizyolojik mekanizmalarla sebum üretimini artırarak rol oynamaktadır. Bu çalışmanın amacı, akne vulgaris tedavi öncesi ve sonrası hemogram parametrelerinde meydana gelen değişiklikleri ortaya koymak ve bu parametrelerin tedavinin değerlendirilmesinde etkinliğini araştırmaktır. Çalışmaya 162 hasta (109 kadın, 67.3%; 53 erkek, 32.7%) dahil edildi. Çalışma sonucunda NEU, MPV, P-LCR ve PDW düzeylerinin tedavi sonrasında anlamlı derecede azaldığı saptandı (p<0.001). NLR ve PLR değerlerinde de tedavi sonrası anlamlı bir düşüş görüldü (p<0.001). LYM ve PLT sayısının ise tedavi sonrası arttığı görüldü (p<0.001). Akne vulgarisli hastalarda sistemik izotretinoin tedavisini değerlendirmede NLR, PLR ve P-LCR gibi hemogram parametreleri etkin şekilde kullanılabilir. 

Keywords

Akne Vulgaris, İnflamasyon, Nötrofil/Lenfosit Oranı, Platelet

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