Obez Sıçanlarda Selenyum ve N-Asetil Sistein’in Fertilite/ İnfertilite ve Karaciğer Üzerine Etkisi

Year 2022, Volume: 9 Issue: 1, 1 - 12, 29.04.2022

Gizem Başaran , Alpaslan Gokcimen , Nazlı Karagöz Can , Uygar Kabaoğlu

https://doi.org/10.47572/muskutd.725703

Abstract

Modern yaşamın getirileri ile beraber değişen beslenme alışkanlıkları ve fiziksel aktivite azlığı, obezitenin dünya genelinde bir halk sağlığı sorunu haline gelmesine neden olmaktadır. Obez bireylerde çeşitli metabolik veya sistemik hastalıklar ortaya çıkmaktadır. Çalışmamızda obeziteye bağlı olarak gelişen karaciğer yağlanması ve fertilite kaybı üzerine selenyum ve N- asetil sistein tedavisinin etkilerini ortaya koymak amaçlanmaktadır. Bu doğrultuda histokimyasal ve immünohistokimyasal tekniklerin yanı sıra serum biyokimya analizleri, oksidatif stres parametreleri ve sperm parametreleri tayinleri yapılmıştır. Selenyum ve N- asetil sisteinin, obezitenin karaciğer ve testis üzerinde oluşturduğu hasarı hem yapısal hem de biyokimyasal düzeyde azalttığını tespit ettik. Ulusal ve uluslararası literatürde ilk kez bu ajanlar kullanılarak obez sıçanlar üzerindeki tedavi edici etkileri gösterilmiştir.  

Keywords

Fertilite, Fertilite, Karaciğer, N-Asetil Sistein, Obezite, Selenyum

Supporting Institution

Adnan Menderes Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi

Project Number

TPF-17040

Thanks

Bilimsel Araştırma Koordinasyon Birimi’ ne desteğinden ötürü teşekkür ederiz.

Effect of Selenium and N-Acetyl Cysteine on Fertility/ Infertility and Liver in Obese Rats

Abstract

Changing dietary habits and lack of physical activity, which are the returns of modern life, cause obesity to become a public health problem worldwide. Various metabolic and systemic diseases develop in obese individuals. The aim of this study was to evaluate the effects of selenium and N-acetylcysteine treatment on obesity-related liver adiposity and loss of fertility. For this purpose, histochemical and immunohistochemical techniques, as well as serum biochemistry analyzes, oxidative stress parameters and sperm parameters were determined. We found that selenium and N-acetylcysteine reduce the damage caused by obesity on both liver and testis both structurally and biochemically. In the national and international literature, the therapeutic effects on obese rats were first demonstrated using these agents. 

Keywords

Fertility, Liver, N-Acetylcysteine, Obesity, Selenium

Project Number

TPF-17040

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