Polikistik Over Sendromu Olan Adölesanlarda Hipoksiyle İndüklenen Faktör (HIF) 1-Alfanın Değerlendirilmesi ve Önemi

Year 2022, Volume: 9 Issue: 2, 109 - 114, 24.08.2022

Bergen Laleli , Burcu Timur , Ömer Hamid Yumuşak , Hüseyin Yeşilyurt

https://doi.org/10.47572/muskutd.947753

Abstract

Adölesan polikistik over sendromu (PCOS) tanısında, serum hipoksiyle indüklenen faktör (HIF)-1 alfanın yerinin, klinik öneminin ve bir biyobelirteç olarak kullanılıp kullanılamayacağının araştırılması amaçlanmıştır. Üçüncü Basamak Kadın Sağlığı Eğitim ve Araştırma Hastanesinde, yaşları 15 ve 22 arasında değişen 30 PCOS’lu hasta, 30 sağlıklı adölesan ve genç yetişkin kadın çalışmaya dahil edildi. Her hastada genel fizik muayene, pelvik muayene ve ultrasonografik değerlendirme yapıldı. Serum açlık glukoz ve insulin seviyesi, lipid profili, HIF-1 alfa seviyesi hastaların esas parametreleri olarak kayıt edildi. Gruplar arasında serum HIF-1 alfa seviyeleri arasında istatistiksel olarak fark bulunmadı. PCOS hasta grubunda ortalama HIF-1 alfa seviyesi, sağlıklı popülasyona göre daha yüksek bulunmasına ragmen bu fark istatistiksel olarak anlamlı değildi. Bel/kalça çevresi oranı, serum LH seviyesi, LH/FSH oranı ve serum androjen seviyeleri PCOS’lu hastalarda kontrollere göre anlamlı olarak yüksek bulundu. Çalışmaya az sayıda hasta dahil edilmesi ve hasta grubunun PCOS semptom ve bulgularının henüz netleşmediği bir dönem olan adölesan yaş aralığını kapsaması, çalışmamızın limitasyonlarını oluşturmaktadır ve olasılıkla çalışma bulgularımızı etkilemiştir. PCOS tanısının konulmasında HIF-1 alfanın yerinin değerlendirilmesi için daha geniş hasta grupları içeren çalışmalara ihtiyaç vardır. 

Keywords

Adölesan, HIF-1 Alfa, Oksidatif Stress, PCOS

Evaluation and Importance of Hypoxia Inducible Factor (HIF)-1-Alpha in Adolescents with Polycystic Ovary Syndrome

Abstract

It was aimed at investigating the place of serum hypoxia inducible factor (HIF)-1 alpha level in the diagnosis of adolescent polycystic ovary syndrome (PCOS), its clinical significance and whether or not it can be used as a biomarker. 30 patients with PCOS and 30 healthy adolescent and young adult women with ages ranging between 15 and 22 were recruited in a grade III Women’s Health Education and Research Hospital. A general physical examination, pelvic examination and ultrasonographic evaluation was carried out on each patient. Serum fasting glucose and insulin levels, lipid profile, HIF-1 alpha levels were recorded as the main parameters of patients. No statistically significant differences were found in serum HIF-1 alpha levels between groups. While the mean HIF-1 alpha levels in PCOS patients was higher as compared to the healthy population, this difference was not statistically significant. Waist/hip circumference ratio, serum LH level, LH/FSH ratio and serum androgen levels in patients with PCOS were significantly higher as compared to control cases. The small number of patients included in the study and the age range covering the adolescence, which is the period that PCOS symptoms and findings have not become clear yet constitute the limitations of our study, and it is possible that they have affected out study results. Place of HIF-1 alpha level in the diagnosis of PCOS must be supported with studies including larger patient groups.

Keywords

Adolescent, HIF-1 Alpha, Oxidative Stress, PCOS

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