Aort Anevrizmaları Progresyonu ile İlişkili Faktörler: Tek Merkez Deneyimi

Year 2024, Volume: 11 Issue: 2, 47 - 52, 31.08.2024

Hande İştar , Buğra Harmandar , Burak Can Depboylu , Serkan Yazman , Fulden Cantaş Türkiş

https://doi.org/10.47572/muskutd.1458198

Abstract

Aort anevrizmaları (AA), yetişkinlerde önemli mortalite sebebidir. Çalışmamızda, torasik aort anevrizması (TAA) ve abdominal aort anevrizması (AAA) ile ilişkili etyolojik faktörleri araştırmayı amaçladık. Çalışmamız 181 bireyi (98’i TAA ve AAA tanılı, 83’ü kontrol grubu) içermektedir. Aort anevrizma (AA) grubunda %72.4’ü erkekti. AA grubunda %57.1’i TAA, %42.9’u AAA tanılıydı. Aorta çapı 41-108 mm aralığında olanlar AA grup içine alındı. İnisiyal serum biyokimya değerleri ve 2 ardışık bilgisayarlı tomografi anjiografi ölçümü değerlendirildi ve her birey için yıllık aort çapı genişlemesi ölçüldü. AA grup ve kontrol grubu ortalama yaşı sırasıyla 62.89±13.55 ve 68.10±11.69 idi (p=0.007), hipertansiyon oranı (p=0.021) daha yüksekti. TAA grubu daha yüksek AST (p=0.016) ve trombosit değerlerine (p=0.010) sahipti. AAA grubunda ise yüksek nötrofil/lenfosit oranı (NLR) (p=0.044) mevcuttu. AAA grubunda erkek oranı %90.5’ti. Sigara kullanımı AAA grubunda daha belirgindi (p=0.08). Bir cm/yıldan daha hızlı anevrizma büyüme hızı oranı, TAA ve AAA gruplarında sırasıyla %25 ve %75 idi. TAA ile yüksek AST ve yüksek trombosit değeri arasında korelasyon mevcuttu. AAA ise erkek cinsiyet, sigara kullanımı ile yakından ilişkili bulundu.

Keywords

Abdominal Aort Anevrizması, ALT, AST, Nötrofil/Lenfosit Oranı, Torasik Aort Anevrizması

Ethical Statement

Etik kurul karar no: (22/06/2022 12/II)

Supporting Institution

Yok

Thanks

Yok

Factors Associated with the Progression of Aortic Aneurysms: A Single-Center Experience

Abstract

Aortic aneurysms (AA) have a significant mortality rate in population. We aimed to identify the etiologic factors associated with thoracic aortic aneurysms (TAAs) and abdominal aortic aneurysms (AAAs). Our study included 181 patients; 98 patients diagnosed with TAA or AAA made up the aortic aneurysm (AA) group, 83 patients without either condition made up the control group. Within the AA group, 72.4% of the patients were male, the patients had been diagnosed with TAA and AAA in ratio of 57.1% and 42.9% respectively. All AA group patients had an aortic diameter in range from 41 to 108 mm. Initial serum biochemical measures, two consecutive computed tomography angiography measurements were recorded, the enlargement rate per year for the aorta was calculated for all. The mean age in the AA group was 62.89±13.55 compared to 68.10±11.69 in the control group (p=0.007), higher ratio for hypertension (p=0.021). TAA patients had a higher AST level (p=0.016) and platelet counts (p=0.010) compared to control group. AAA patients had a higher mean neutrophil/lymphocyte ratio (NLR) (p=0.044) compared to control group. Among the patients with AAA, 90.5 % were male. Smoking was more prevalent in the abdominal AA group (p=0.08). An enlargement rate of more than 1 cm/year was detected in 25% of the patients with TAA and in 75% of the patients with AAA. TAA was associated with higher AST levels and higher platelet counts than were in the AAA group, whereas AAA showed strong relationships with male gender and smoking.

Keywords

Abdominal Aortic Aneurysm, ALT, AST, Neutrophil/Lymphocyte Ratio, Thoracic Aortic Aneurysm

Ethical Statement

Ethical approval was obtained from local review board (22/06/2022 12/II)

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