Risk of Recurrence After Anti-Seizure Medication Discontinuation

Year 2024, Volume: 11 Issue: 2, 62 - 67, 31.08.2024

Firdevs Ezgi Uçan Tokuç , Merve Gürsoy Hasoğlan , Fatma Genç , Meltem Korucuk , Abidin Erdal , Yasemin Biçer Gömceli

https://doi.org/10.47572/muskutd.1482913

Abstract

With appropriate anti-seizure medication, long-term seizure freedom can be achieved in about 2/3 of patients with epilepsy. After long-term seizure freedom, the idea of medication discontinuation arises for both patients and physicians. In this study, we aimed to investigate seizure recurrence rates and the factors affecting recurrence in patients whose anti-seizure medication treatment was discontinued. Fifty patients were included in the study. Twenty-eight (56%) patients were female, with a mean age of 41.28±14.58 years and a mean duration of epilepsy of 15.20±9.90 years. Recurrence was observed in 14 (28%) patients. When the recurrence risk factors were analyzed, it was observed that the risk of recurrence decreased as the seizure-free period increased. Our study supports that the risk of relapse after discontinuation of anti-seizure medications decreases as the seizure-free period is prolonged. However, it should not be forgotten that the decision to discontinue medication should be individualized.

Keywords

Epilepsy, Anti-Seizure Medication Discontinuation, Seizure-Free, Recurrence

Ethical Statement

This study was approved by the human ethics committee of Antalya Training and Research Hospital. 25.04.2024 with protocol code 2024/072.

Supporting Institution

No financial support was received from any institution, organization or person in our study.

Nöbet Önleyici İlaç kesimi Sonrası Rekürrens Riski

Abstract

Uygun nöbet önleyici ilaç tedavisi ile epilepsi hastalarının yaklaşık 2/3'ünde nöbetsizlik sağlanabilmektedir. Uzun süreli nöbetsizlikten sonra hem hastalar hem de hekimler için ilaçların kesilmesi fikri ön plana çıkmaktadır. Biz de bu çalışma ile nöbet önleyici ilaç tedavisi kesilen hastalarda nöbet nüks oranlarını ve nüksü etkileyen faktörleri araştırmayı amaçladık. Çalışmaya 50 hasta dahil edildi. Hastaların 28'i (%56) kadındı, yaş ortalaması 41.28±14.58 yıl ve ortalama epilepsi süresi 15.20±9.90 yıldı. Hastaların 14'ünde (%28) nüks gözlendi. Nüks risk faktörleri incelendiğinde, nöbetsizlik süresi arttıkça nüks riskinin azaldığı tespit edildi. Çalışmamız nöbet önleyici ilaçların kesilmesinden sonra nüks riskinin ilaç kesim öncesi nöbetsizlik süresi uzadıkça azaldığını desteklemektedir. Ancak, ilacı bırakma kararının hasta bazında bireyselleştirilmesi gerektiği unutulmamalıdır.

Keywords

Epilepsi, Nöbet Önleyici İlaç Kesimi, Nöbetsizlik, Nüks

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