Monograph
BibTex RIS Cite

Argan Oil and Evaluation of Its Biological Activities

Year 2022, Volume: 12 Issue: 2, 238 - 246, 30.05.2022
https://doi.org/10.31020/mutftd.1027569

Abstract

Argania spinosa is a member of the Sapotaceae family and is an endemic tree that grows in approximately 800,000 hectares in Southwest Morocco. It is registered that the argan oil obtained from the seeds of the plant is used by the people of the region in dermatological disorders and to lighten skin color. Because of its high content of oleic acid, linoleic acid, and polyphenols has become noticeable among other fixed oil sources. Recently, it has become exceptionally preferred in the cosmetic industry and has found its place in various formulations in pure or enriched forms. Apart from dermo-cosmetic use, there are many studies on the plant's chemical contents and biological activities, primarily argan oil. In this study, biological activity and dermatological effect studies of argan oil obtained from SciFinder, Google Scholar, ScienceDirect databases were listed and evaluated in terms of cosmetic use. As a result of the evaluations, it was determined that the ethnobotanical uses of argan oil, the preparations and formulations prepared for dermocosmetic use and the compiled biological activity studies showed parallelism. In the study, case reports that argan oils used for cosmetic purposes can cause allergic reactions are also included and the need for more side/toxic effect profile studies on argan oil has been revealed.

References

  • 1. Abbassi A, et al. Physicochemical characteristics, nutritional properties, and health benefits of Argan oil: A Review. Crit Rev Food 2014;54(11):1401-1414.
  • 2. Mechqoq H, et al. The ethnobotany, phytochemistry and biological properties of Argan tree (Argania spinosa (L.) Skeels) (Sapotaceae)-A review. J Ethnopharmacol 2021;114528.
  • 3. Charrouf Z, Guillaume D. The argan oil project: going from utopia to reality in 20 years. OCL 2018;25(2):D209.
  • 4. Guillaume D, Charrouf Z. Argan oil and other argan products: Use in dermocosmetology. Eur J Lipid Sci Technol 2011;113:403–408.
  • 5. El Monfalouti H, et al. Therapeutic potential of argan oil: A review. J Pharm Pharmacol 2010;62:1669–1675.
  • 6. Abouri M, et al. An ethnobotanical survey of medicinal plants used in the Tata Province, Morocco. J Med Plant Res 2012;1(7):99–123.
  • 7. Katiri A, et al. Ethnobotanical survey of medicinal plants used for the treatment of diabetes in the tizi n’Test region (taroudant province, Morocco). J Pharmacogn Nat Prod 2017;3(130): 1-10.
  • 8. Ouhaddou H, et al. An ethnobotanical study of medicinal plants of the Agadir Ida Ou Tanane province (Southwest Morocco). J Appl Biosci 2014;84:7707–7722.
  • 9. Charrouf Z, Guillaume D. Ethnoeconomical, ethnomedical, and phytochemical study of Argania spinosa (L.) Skeels. J Ethnopharmacol 1999;67(1):7–14.
  • 10. El Kabouss A, et al. Chemical composition and antimicrobial activity of the leaf essential oil of Argania spinosa L. Skeels. JEOR 2002; 14(2):147–149.
  • 11. Saadi B, Msanda F, Boubaker H. Contributions of folk medicine knowledge in Southwestern Morocco: the case of rural communities of Imouzzer Ida Outanane Region. Int J Methods Psychiatr Res 2013;135–145.
  • 12. Khallouki F, et al. Ethnobotanic, ethnopharmacologic aspects and new phytochemical insights into moroccan argan fruits. Int J Mol Sci 2017;18(11):2277.
  • 13. Taribak C, et al. Quality of cosmetic argan oil extracted by supercritical fluid extraction from Argania spinosa L. J Chem 2013;220:1-9.
  • 14. Guillaume D, Charrouf Z. Argan oil. Altern Med Rev 2011;16: 275–279.
  • 15. Khallouki F, et al. Consumption of argan oil (Morocco) with its unique profile of fatty acids, tocopherols, squalene, sterols and phenolic compounds should confer valuable cancer chemopreventive effects. J Cancer Prev 2003;12(1):67–75.
  • 16. Khallouki F, et al. Secondary metabolites of the argan tree (Morocco) may have disease prevention properties, Afr J Biotechnol 2005;4:381–288.
  • 17. Hilali M, et al. Influence of origin and extraction method on argan oil physico-chemical characteristics and composition. J Agric Food Chem 2005;53(6):2081–2087.
  • 18. Taneva S, et al. Lipid composition and oxidative stability of argan and cactus opuntia ficus indica seed oils from Morocco – Assessment of two extraction method. J Chem Technol 2021;56:548–560.
  • 19. Charrouf Z, Guillaume D. Argan oil: occurrence, composition and impact on human health. Eur J Lipid Sci Technol 2008;110(7):632–636.
  • 20. Tuberoso C, et al. Determination of antioxidant compounds and antioxidant activity in commercial oil seeds for food use, Food Chem 2007;103:1494–1501.
  • 21. Marfil R, et al. Determination of polyphenols, tocopherols, and antioxidant capacity in virgin argan oil (Argania spinosa, Skeels). Eur J Lipid Sci Technol 2011;113(7):886–893.
  • 22. Kamal R, et al. In vivo anti-inflammatory response and bioactive compounds’ profile of polyphenolic extracts from edible Argan oil (Argania spinosa L.), obtained by two extraction methods. J Food Biochem 2019;43(12):1-11.
  • 23. Aydın B. Effects of argan oil on the mitochondrial function, antioxidants system and the activity of NADPH- generating enzymes in acrylamide treated rat brain. Biomed Pharmacother 2017;87:476-481.
  • 24. Berrougui H, et al. Argan (Argania spinosa) oil lowers blood pressure and improves endothelial dysfunction in spontaneously hypertensive rats, Br J Nutr 2004;92:921–929.
  • 25. Bahbiti Y, et al. Anticonvulsant effect of argan oil on pilocarpine model induced status epilepticus in wistar rats. Nutr Neurosci 2018;21(2):116–122.
  • 26. Bouchab H, et al. Protective effect of argan oil on DNA damage in vivo and in vitro. Biomarkers 2021;26(5):425-433.
  • 27. Bnouham M, et al. Antidiabetic activity assessment of Argania spinosa oil. J Complement Integr 2008;5:32.
  • 28. Ainane T, et al. Moroccan formulation of oils for the care of hair: Chemical composition and antibacterial activity. SOJ Biochemistry 2016;2(2):8.
  • 29. Aribi B, et al. Effect of Argania spinosa oil extract on proliferation and Notch1 and ERK1/2 signaling of T-cell acute lymphoblastic leukemia cell lines. Agr Immunol 2016;27(3):350-357.
  • 30. Villareal MO, et al. Activation of MITF by argan oil leads to the inhibition of the tyrosinase and dopachrome tautomerase expressions in B16 murine melanoma cells 2013;340107:1-9.
  • 31. Faria PM, et al. Hair protective effect of Argan oil (Argania spinosa Kernel oil) and Cupuassu butter (Theobroma grandiflorum seed butter) post treatment with hair dye. JCDSA 2013;3(03):40.
  • 32. Dakiche H, Khali M, Boutoumi H. Phytochemical characterization and in vivo anti-inflammatory and wound-healing activities of Argania spinosa (L.) Skeels seed oil. Rec Nat Prod 2017;11(2):171-184.
  • 33. Boucetta KQ, et al. The effect of dietary and/or cosmetic argan oil on postmenopausal skin elasticity. Clin Interv Aging 2015;10:339.
  • 34. Boucetta KQ, et al. Skin hydration in postmenopausal women: Argan oil benefit with oral and/or topical use. Menopause review 2014;13(5):280.
  • 35. Manca, ML, et al. Combination of argan oil and phospholipids for the development of an effective liposome-like formulation able to improve skin hydration and allantoin dermal delivery: International journal of pharmaceutics 2016;505(1-2):204-211.
  • 36. Orabi SH, et al. The Antioxidant, anti-apoptotic, and proliferative potency of argan oil against betamethasone-induced oxidative renal damage in rats. Biology 2020;9(11):352.
  • 37. Ould Mohamedou MM, et al. Argan oil exerts an antiatherogenic effect by improving lipids and susceptibility of LDL to oxidation in Type 2 diabetes patients. Int J Endocrinol 2011;747835.
  • 38. Hashemi JM, Alahmari SA. Effect of argan oil (Argania spinosa) on hypercholesterolemic male rats. Med Sci 2021;25(111):1150-1158.
  • 39. Lall N, et al. The anti-proliferative and anti-bacterial activity of argan oil and crude saponin extract from Argania spinosa (L.) Skeels. Pharmacogn J 2019;11(1):26-31.
  • 40. Al-Saffar AK, Al-Dahmoshi HOM. Effect of argan oil-hydrogen peroxide mixture on Mycobacterium tuberculosis-in vitro. Medical Microbiology & Diagnosis 2015;3:703-2161.
  • 41. Bennani H. Impact of argan oil on prostate cancer antiproliferative effect: study of polyphenols. Rev Franco Lab 2009;416:23–26.
  • 42. Foti C, et al. Allergic contact dermatitis caused by argan oil. Contact Derm 2014;71:176-190.
  • 43. Astier C, et al. Anaphylaxis to argan oil. Allergy 2010;65:662-669.
  • 44. Paris C, et al. First evidence of occupational asthma to argan powder in a cosmetic factory. Allergy 2015;71:550–555.
  • 45. Veraldi S, Mascagni P, Tosi D. Allergic contact dermatitis caused by argan oil. Dermatitis 2016;27(6):391-391.
  • 46. Manca ML, et al. Nanotechnology for natural medicine: formulation of neem oil loaded phospholipid vesicles modified with argan oil as a strategy to protect the skin from oxidative stress and promotewound healing. Antioxidants 2021;10:670.

Argan Yağı ve Biyolojik Aktivitelerinin Değerlendirilmesi

Year 2022, Volume: 12 Issue: 2, 238 - 246, 30.05.2022
https://doi.org/10.31020/mutftd.1027569

Abstract

Argania spinosa, Sapotaceae familyasının üyesi olup Güneybatı Fas bölgesinde yaklaşık 800.000 hektarlık bir alanda endemik yetişen bir ağaçtır. Bitkinin tohumlarından elde edilen argan yağının bölge halkı tarafından dermatolojik rahatsızlıklarda ve cilt rengini açmak üzere kullanıldığı kayıtlıdır. İçeriğinde yüksek oranda bulunan oleik asit, linoleik asit ve polifenoller sayesinde diğer sabit yağ kaynakları içerisinde fark edilir hale gelmiştir. Son dönemde kozmetik alanında çok tercih edilir olmuş, saf veya zenginleştirilmiş formlarda çeşitli formülasyonlarda kendine yer bulmuştur. Dermokozmetik kullanımı dışında öncelikle argan yağı olmak üzere bitkiden elde edilen drogların kimyasal içerikleri ve biyolojik aktiviteleri üzerinde çok sayıda çalışma bulunmaktadır. Bu çalışmada, argan yağına ait, SciFinder, Google Scholar, ScienceDirect veri tabanlarından elde edilen biyolojik aktivite ve dermotolojik etki çalışmaları listelenmiş ve kozmetik kullanımı açısından değerlendirilmiştir. Yapılan değerlendirmeler sonucunda, argan yağının etnobotanik kullanımlarının, dermokozmetik kullanım için hazırlanan preparat ve formülasyonlarının ve derlenen biyolojik aktivite çalışmalarının parallelik gösterdiği saptanmıştır. Çalışmada kozmetik amaçlar için kullanılan argan yağlarının alerjik reaksiyonlara sebep olabildiğine dair vaka raporlarına da yer verilmiş ve argan yağı üzerinde daha fazla yan/toksik etki profil çalışmalarının gerekliliği ortaya konmuştur.

References

  • 1. Abbassi A, et al. Physicochemical characteristics, nutritional properties, and health benefits of Argan oil: A Review. Crit Rev Food 2014;54(11):1401-1414.
  • 2. Mechqoq H, et al. The ethnobotany, phytochemistry and biological properties of Argan tree (Argania spinosa (L.) Skeels) (Sapotaceae)-A review. J Ethnopharmacol 2021;114528.
  • 3. Charrouf Z, Guillaume D. The argan oil project: going from utopia to reality in 20 years. OCL 2018;25(2):D209.
  • 4. Guillaume D, Charrouf Z. Argan oil and other argan products: Use in dermocosmetology. Eur J Lipid Sci Technol 2011;113:403–408.
  • 5. El Monfalouti H, et al. Therapeutic potential of argan oil: A review. J Pharm Pharmacol 2010;62:1669–1675.
  • 6. Abouri M, et al. An ethnobotanical survey of medicinal plants used in the Tata Province, Morocco. J Med Plant Res 2012;1(7):99–123.
  • 7. Katiri A, et al. Ethnobotanical survey of medicinal plants used for the treatment of diabetes in the tizi n’Test region (taroudant province, Morocco). J Pharmacogn Nat Prod 2017;3(130): 1-10.
  • 8. Ouhaddou H, et al. An ethnobotanical study of medicinal plants of the Agadir Ida Ou Tanane province (Southwest Morocco). J Appl Biosci 2014;84:7707–7722.
  • 9. Charrouf Z, Guillaume D. Ethnoeconomical, ethnomedical, and phytochemical study of Argania spinosa (L.) Skeels. J Ethnopharmacol 1999;67(1):7–14.
  • 10. El Kabouss A, et al. Chemical composition and antimicrobial activity of the leaf essential oil of Argania spinosa L. Skeels. JEOR 2002; 14(2):147–149.
  • 11. Saadi B, Msanda F, Boubaker H. Contributions of folk medicine knowledge in Southwestern Morocco: the case of rural communities of Imouzzer Ida Outanane Region. Int J Methods Psychiatr Res 2013;135–145.
  • 12. Khallouki F, et al. Ethnobotanic, ethnopharmacologic aspects and new phytochemical insights into moroccan argan fruits. Int J Mol Sci 2017;18(11):2277.
  • 13. Taribak C, et al. Quality of cosmetic argan oil extracted by supercritical fluid extraction from Argania spinosa L. J Chem 2013;220:1-9.
  • 14. Guillaume D, Charrouf Z. Argan oil. Altern Med Rev 2011;16: 275–279.
  • 15. Khallouki F, et al. Consumption of argan oil (Morocco) with its unique profile of fatty acids, tocopherols, squalene, sterols and phenolic compounds should confer valuable cancer chemopreventive effects. J Cancer Prev 2003;12(1):67–75.
  • 16. Khallouki F, et al. Secondary metabolites of the argan tree (Morocco) may have disease prevention properties, Afr J Biotechnol 2005;4:381–288.
  • 17. Hilali M, et al. Influence of origin and extraction method on argan oil physico-chemical characteristics and composition. J Agric Food Chem 2005;53(6):2081–2087.
  • 18. Taneva S, et al. Lipid composition and oxidative stability of argan and cactus opuntia ficus indica seed oils from Morocco – Assessment of two extraction method. J Chem Technol 2021;56:548–560.
  • 19. Charrouf Z, Guillaume D. Argan oil: occurrence, composition and impact on human health. Eur J Lipid Sci Technol 2008;110(7):632–636.
  • 20. Tuberoso C, et al. Determination of antioxidant compounds and antioxidant activity in commercial oil seeds for food use, Food Chem 2007;103:1494–1501.
  • 21. Marfil R, et al. Determination of polyphenols, tocopherols, and antioxidant capacity in virgin argan oil (Argania spinosa, Skeels). Eur J Lipid Sci Technol 2011;113(7):886–893.
  • 22. Kamal R, et al. In vivo anti-inflammatory response and bioactive compounds’ profile of polyphenolic extracts from edible Argan oil (Argania spinosa L.), obtained by two extraction methods. J Food Biochem 2019;43(12):1-11.
  • 23. Aydın B. Effects of argan oil on the mitochondrial function, antioxidants system and the activity of NADPH- generating enzymes in acrylamide treated rat brain. Biomed Pharmacother 2017;87:476-481.
  • 24. Berrougui H, et al. Argan (Argania spinosa) oil lowers blood pressure and improves endothelial dysfunction in spontaneously hypertensive rats, Br J Nutr 2004;92:921–929.
  • 25. Bahbiti Y, et al. Anticonvulsant effect of argan oil on pilocarpine model induced status epilepticus in wistar rats. Nutr Neurosci 2018;21(2):116–122.
  • 26. Bouchab H, et al. Protective effect of argan oil on DNA damage in vivo and in vitro. Biomarkers 2021;26(5):425-433.
  • 27. Bnouham M, et al. Antidiabetic activity assessment of Argania spinosa oil. J Complement Integr 2008;5:32.
  • 28. Ainane T, et al. Moroccan formulation of oils for the care of hair: Chemical composition and antibacterial activity. SOJ Biochemistry 2016;2(2):8.
  • 29. Aribi B, et al. Effect of Argania spinosa oil extract on proliferation and Notch1 and ERK1/2 signaling of T-cell acute lymphoblastic leukemia cell lines. Agr Immunol 2016;27(3):350-357.
  • 30. Villareal MO, et al. Activation of MITF by argan oil leads to the inhibition of the tyrosinase and dopachrome tautomerase expressions in B16 murine melanoma cells 2013;340107:1-9.
  • 31. Faria PM, et al. Hair protective effect of Argan oil (Argania spinosa Kernel oil) and Cupuassu butter (Theobroma grandiflorum seed butter) post treatment with hair dye. JCDSA 2013;3(03):40.
  • 32. Dakiche H, Khali M, Boutoumi H. Phytochemical characterization and in vivo anti-inflammatory and wound-healing activities of Argania spinosa (L.) Skeels seed oil. Rec Nat Prod 2017;11(2):171-184.
  • 33. Boucetta KQ, et al. The effect of dietary and/or cosmetic argan oil on postmenopausal skin elasticity. Clin Interv Aging 2015;10:339.
  • 34. Boucetta KQ, et al. Skin hydration in postmenopausal women: Argan oil benefit with oral and/or topical use. Menopause review 2014;13(5):280.
  • 35. Manca, ML, et al. Combination of argan oil and phospholipids for the development of an effective liposome-like formulation able to improve skin hydration and allantoin dermal delivery: International journal of pharmaceutics 2016;505(1-2):204-211.
  • 36. Orabi SH, et al. The Antioxidant, anti-apoptotic, and proliferative potency of argan oil against betamethasone-induced oxidative renal damage in rats. Biology 2020;9(11):352.
  • 37. Ould Mohamedou MM, et al. Argan oil exerts an antiatherogenic effect by improving lipids and susceptibility of LDL to oxidation in Type 2 diabetes patients. Int J Endocrinol 2011;747835.
  • 38. Hashemi JM, Alahmari SA. Effect of argan oil (Argania spinosa) on hypercholesterolemic male rats. Med Sci 2021;25(111):1150-1158.
  • 39. Lall N, et al. The anti-proliferative and anti-bacterial activity of argan oil and crude saponin extract from Argania spinosa (L.) Skeels. Pharmacogn J 2019;11(1):26-31.
  • 40. Al-Saffar AK, Al-Dahmoshi HOM. Effect of argan oil-hydrogen peroxide mixture on Mycobacterium tuberculosis-in vitro. Medical Microbiology & Diagnosis 2015;3:703-2161.
  • 41. Bennani H. Impact of argan oil on prostate cancer antiproliferative effect: study of polyphenols. Rev Franco Lab 2009;416:23–26.
  • 42. Foti C, et al. Allergic contact dermatitis caused by argan oil. Contact Derm 2014;71:176-190.
  • 43. Astier C, et al. Anaphylaxis to argan oil. Allergy 2010;65:662-669.
  • 44. Paris C, et al. First evidence of occupational asthma to argan powder in a cosmetic factory. Allergy 2015;71:550–555.
  • 45. Veraldi S, Mascagni P, Tosi D. Allergic contact dermatitis caused by argan oil. Dermatitis 2016;27(6):391-391.
  • 46. Manca ML, et al. Nanotechnology for natural medicine: formulation of neem oil loaded phospholipid vesicles modified with argan oil as a strategy to protect the skin from oxidative stress and promotewound healing. Antioxidants 2021;10:670.
There are 46 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Monograph
Authors

Nurdan Yazıcı Bektaş 0000-0001-7617-1701

Çağlayan Gürer 0000-0002-8244-4152

Early Pub Date May 25, 2022
Publication Date May 30, 2022
Submission Date November 23, 2021
Published in Issue Year 2022 Volume: 12 Issue: 2

Cite

APA Yazıcı Bektaş, N., & Gürer, Ç. (2022). Argan Yağı ve Biyolojik Aktivitelerinin Değerlendirilmesi. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi Ve Folklorik Tıp Dergisi, 12(2), 238-246. https://doi.org/10.31020/mutftd.1027569
AMA Yazıcı Bektaş N, Gürer Ç. Argan Yağı ve Biyolojik Aktivitelerinin Değerlendirilmesi. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi. May 2022;12(2):238-246. doi:10.31020/mutftd.1027569
Chicago Yazıcı Bektaş, Nurdan, and Çağlayan Gürer. “Argan Yağı Ve Biyolojik Aktivitelerinin Değerlendirilmesi”. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi Ve Folklorik Tıp Dergisi 12, no. 2 (May 2022): 238-46. https://doi.org/10.31020/mutftd.1027569.
EndNote Yazıcı Bektaş N, Gürer Ç (May 1, 2022) Argan Yağı ve Biyolojik Aktivitelerinin Değerlendirilmesi. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi 12 2 238–246.
IEEE N. Yazıcı Bektaş and Ç. Gürer, “Argan Yağı ve Biyolojik Aktivitelerinin Değerlendirilmesi”, Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi, vol. 12, no. 2, pp. 238–246, 2022, doi: 10.31020/mutftd.1027569.
ISNAD Yazıcı Bektaş, Nurdan - Gürer, Çağlayan. “Argan Yağı Ve Biyolojik Aktivitelerinin Değerlendirilmesi”. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi 12/2 (May 2022), 238-246. https://doi.org/10.31020/mutftd.1027569.
JAMA Yazıcı Bektaş N, Gürer Ç. Argan Yağı ve Biyolojik Aktivitelerinin Değerlendirilmesi. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi. 2022;12:238–246.
MLA Yazıcı Bektaş, Nurdan and Çağlayan Gürer. “Argan Yağı Ve Biyolojik Aktivitelerinin Değerlendirilmesi”. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi Ve Folklorik Tıp Dergisi, vol. 12, no. 2, 2022, pp. 238-46, doi:10.31020/mutftd.1027569.
Vancouver Yazıcı Bektaş N, Gürer Ç. Argan Yağı ve Biyolojik Aktivitelerinin Değerlendirilmesi. Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi. 2022;12(2):238-46.

                                                                                                                                  Creative Commons Lisansı                        
                                                                  This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

  

                                    Periodical scientific publication of Mersin University School of Medicine. Can not be cited without referenceResponsibility of the articles belong to the authors

  Cover

Ayşegül Tuğuz

from composition of İlter Uzel named Dioscorides and his Student

Address

Mersin Üniversitesi Tıp Fakültesi Tıp Tarihi ve Etik Anabilim Dalı Çiftlikköy Kampüsü

Yenişehir / Mersin