Süt Çocuğunda Nadir Bir Durum: Eksantem Subitum Kaynaklı Ensefalit
Yıl 2025,
Sayı: 3, 150 - 154, 14.03.2025
Umut Yorulmaz
,
Osman Yiğitoğlu
,
Derviş Barın
,
Saliha Yavuz Eravcı
,
Hüseyin Çaksen
,
Abdullah Akkuş
Öz
Viral ensefalit virüslerin neden olduğu beyin parankimi inflamasyonudur. Human Herpesvirüs -6 (HHV-6)da bu viral enfeksiyon sebeplerinden biri olup bebeklerde ve çocuklarda ateş, döküntü, farenjit ve genellikle hafif sistemik belirtilerle karakterizeyken nadiren ensefalit sebebi olabilmektedir. Sunulan vakada da dirençli nöbetlerle karakterize olan hastadan gerekli tetkikler yapılmış olup HHV-6 ensefaliti tanısı konulmuştur. Dirençli nöbet ile gelen vakalarda eksantem subitum enfeksiyonuna bağlı olabileceği akılda tutulmalıdır.
Kaynakça
- Michos AG, Syriopoulou VP, Hadjichristodoulou C, et al. Asepticmeningitis in children: analysis of 506 cases. PLoSOne. 2007;2(7):e674. doi:10.1371/journal.pone.0000674.
- Martin NG, Iro MA, Sadarangani M, et al. Hospitaladmissionsfor viral meningitis in children in England over fivedecades: a population-basedobservationalstudy. Lancet InfectDis. 2016;16(11):1279-87. doi:10.1016/S1473-3099(16)30201-8.
- Hviid A, Melbye M. Theepidemiology of viral meningitishospitalization in childhood. Epidemiology. 2007;18(6):695-701. doi:10.1097/ede.0b013e3181567d31.
- CentersforDisease Control andPrevention (CDC). Outbreaks of asepticmeningitisassociatedwithechoviruses 9 and 30 andpreliminarysurveillancereports on enterovirusactivity—United States, 2003. MMWR Morb Mortal WklyRep. 2003;52(32):761-4.
- Dağdelen EÇ, Kılıç Çil M, Çelik T, et al. Theetiology, clinicalcharacteristicsandtreatmentmodalities in childrenwithmeningitisandencephalitis: A retrospectivesinglecenterstudy in Türkiye. J Pediatr Inf. 2023;17(4):234-41. doi:10.5578/ced.20239911.
- Said S, Kang M. Viral Encephalitis. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Availablefrom: https://www.ncbi.nlm.nih.gov/books/NBK470162/
- Yamanishi K, Okuno T, Shiraki K, et al. Identification of human herpesvirus-6 as a causalagentforexanthemsubitum. Lancet. 1988;1(8594):1065-7. doi:10.1016/S0140-6736(88)91893-9.
- Agut H, Bonnafous P, Gautheret-Dejean A. Laboratoryandclinicalaspects of humanherpesvirus 6 infections. ClinMicrobiolRev. 2015;28(2):313-35. doi:10.1128/CMR.00122-14.
- Rhoads MP, Magaret AS, Zerr DM. Familysalivasharingbehaviorsandage of human herpesvirus-6B infection. J Infect. 2007;54(6):623-6. doi:10.1016/j.jinf.2006.11.006.
- Saxinger C, Polesky H, Eby N, et al. Antibodyreactivitywith HBLV (HHV-6) in U.S. populations. J VirolMethods. 1988;21(1-4):199-208. doi:10.1016/0166-0934(88)90062-4.
- Hall CB, Long CE, Schnabel KC, et al. Human herpesvirus-6 infection in children: A prospectivestudy of complicationsandreactivation. N Engl J Med. 1994;331(7):432-8. doi:10.1056/NEJM199408183310703.
- Suga S, Suzuki K, Ihira M, et al. Clinicalcharacteristics of febrileconvulsionsduringprimary HHV-6 infection. ArchDis Child. 2000;82(1):62-6. doi:10.1136/adc.82.1.62.
- Abu Sitta E, Khazan A, Luttmann K, et al. HHV-6: an unusualcause of cerebellarataxia. BMJ Case Rep. 2020;13(3):e234303. doi:10.1136/bcr-2020-234303.
- Crawford JR, Kadom N, Santi MR, et al. Human herpesvirus 6 rhombencephalitisin immunocompetentchildren. J Child Neurol. 2007;22(11):1260-8. doi:10.1177/0883073807307102.
- Akın F, Yazar A, Türe E, et al. A raredisease: Encephalitisafterexanthemsubitum. Haydarpaşa Numune Med J. 2017;57(2):112-4. doi:10.14744/hnhj.2017.83997.
- Bartolini L, Theodore WH, Jacobson S, et al. Infectionwith HHV-6 andits role in epilepsy. EpilepsyRes. 2019;153:34-9. doi:10.1016/j.eplepsyres.2019.05.001.
A Rare Condition in Infants: Exanthem Subitum-Induced Encephalitis
Yıl 2025,
Sayı: 3, 150 - 154, 14.03.2025
Umut Yorulmaz
,
Osman Yiğitoğlu
,
Derviş Barın
,
Saliha Yavuz Eravcı
,
Hüseyin Çaksen
,
Abdullah Akkuş
Öz
Viral encephalitis is inflammation of the brain parenchyma caused by viruses. HHV-6 is one of the causes of this viral infection and is characterized by fever, rash, pharyngitis and generally mild systemic symptoms in infants and children, but it can rarely cause encephalitis. In the present case, a patient with refractory seizures underwent necessary investigations and was diagnosed with HHV-6 encephalitis. In patients presenting with refractory seizures, it should be kept in mind that the seizure may be due to exanthem subitum infection.
Kaynakça
- Michos AG, Syriopoulou VP, Hadjichristodoulou C, et al. Asepticmeningitis in children: analysis of 506 cases. PLoSOne. 2007;2(7):e674. doi:10.1371/journal.pone.0000674.
- Martin NG, Iro MA, Sadarangani M, et al. Hospitaladmissionsfor viral meningitis in children in England over fivedecades: a population-basedobservationalstudy. Lancet InfectDis. 2016;16(11):1279-87. doi:10.1016/S1473-3099(16)30201-8.
- Hviid A, Melbye M. Theepidemiology of viral meningitishospitalization in childhood. Epidemiology. 2007;18(6):695-701. doi:10.1097/ede.0b013e3181567d31.
- CentersforDisease Control andPrevention (CDC). Outbreaks of asepticmeningitisassociatedwithechoviruses 9 and 30 andpreliminarysurveillancereports on enterovirusactivity—United States, 2003. MMWR Morb Mortal WklyRep. 2003;52(32):761-4.
- Dağdelen EÇ, Kılıç Çil M, Çelik T, et al. Theetiology, clinicalcharacteristicsandtreatmentmodalities in childrenwithmeningitisandencephalitis: A retrospectivesinglecenterstudy in Türkiye. J Pediatr Inf. 2023;17(4):234-41. doi:10.5578/ced.20239911.
- Said S, Kang M. Viral Encephalitis. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Availablefrom: https://www.ncbi.nlm.nih.gov/books/NBK470162/
- Yamanishi K, Okuno T, Shiraki K, et al. Identification of human herpesvirus-6 as a causalagentforexanthemsubitum. Lancet. 1988;1(8594):1065-7. doi:10.1016/S0140-6736(88)91893-9.
- Agut H, Bonnafous P, Gautheret-Dejean A. Laboratoryandclinicalaspects of humanherpesvirus 6 infections. ClinMicrobiolRev. 2015;28(2):313-35. doi:10.1128/CMR.00122-14.
- Rhoads MP, Magaret AS, Zerr DM. Familysalivasharingbehaviorsandage of human herpesvirus-6B infection. J Infect. 2007;54(6):623-6. doi:10.1016/j.jinf.2006.11.006.
- Saxinger C, Polesky H, Eby N, et al. Antibodyreactivitywith HBLV (HHV-6) in U.S. populations. J VirolMethods. 1988;21(1-4):199-208. doi:10.1016/0166-0934(88)90062-4.
- Hall CB, Long CE, Schnabel KC, et al. Human herpesvirus-6 infection in children: A prospectivestudy of complicationsandreactivation. N Engl J Med. 1994;331(7):432-8. doi:10.1056/NEJM199408183310703.
- Suga S, Suzuki K, Ihira M, et al. Clinicalcharacteristics of febrileconvulsionsduringprimary HHV-6 infection. ArchDis Child. 2000;82(1):62-6. doi:10.1136/adc.82.1.62.
- Abu Sitta E, Khazan A, Luttmann K, et al. HHV-6: an unusualcause of cerebellarataxia. BMJ Case Rep. 2020;13(3):e234303. doi:10.1136/bcr-2020-234303.
- Crawford JR, Kadom N, Santi MR, et al. Human herpesvirus 6 rhombencephalitisin immunocompetentchildren. J Child Neurol. 2007;22(11):1260-8. doi:10.1177/0883073807307102.
- Akın F, Yazar A, Türe E, et al. A raredisease: Encephalitisafterexanthemsubitum. Haydarpaşa Numune Med J. 2017;57(2):112-4. doi:10.14744/hnhj.2017.83997.
- Bartolini L, Theodore WH, Jacobson S, et al. Infectionwith HHV-6 andits role in epilepsy. EpilepsyRes. 2019;153:34-9. doi:10.1016/j.eplepsyres.2019.05.001.