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Süt Çocuğunda Nadir Bir Durum: Eksantem Subitum Kaynaklı Ensefalit

Yıl 2025, Sayı: 3, 150 - 154, 14.03.2025
https://doi.org/10.70846/nigdetip.1564248

Öz

Viral ensefalit virüslerin neden olduğu beyin parankimi inflamasyonudur. Human Herpesvirüs -6 (HHV-6)da bu viral enfeksiyon sebeplerinden biri olup bebeklerde ve çocuklarda ateş, döküntü, farenjit ve genellikle hafif sistemik belirtilerle karakterizeyken nadiren ensefalit sebebi olabilmektedir. Sunulan vakada da dirençli nöbetlerle karakterize olan hastadan gerekli tetkikler yapılmış olup HHV-6 ensefaliti tanısı konulmuştur. Dirençli nöbet ile gelen vakalarda eksantem subitum enfeksiyonuna bağlı olabileceği akılda tutulmalıdır.

Kaynakça

  • Michos AG, Syriopoulou VP, Hadjichristodoulou C, et al. Asepticmeningitis in children: analysis of 506 cases. PLoSOne. 2007;2(7):e674. doi:10.1371/journal.pone.0000674.
  • Martin NG, Iro MA, Sadarangani M, et al. Hospitaladmissionsfor viral meningitis in children in England over fivedecades: a population-basedobservationalstudy. Lancet InfectDis. 2016;16(11):1279-87. doi:10.1016/S1473-3099(16)30201-8.
  • Hviid A, Melbye M. Theepidemiology of viral meningitishospitalization in childhood. Epidemiology. 2007;18(6):695-701. doi:10.1097/ede.0b013e3181567d31.
  • CentersforDisease Control andPrevention (CDC). Outbreaks of asepticmeningitisassociatedwithechoviruses 9 and 30 andpreliminarysurveillancereports on enterovirusactivity—United States, 2003. MMWR Morb Mortal WklyRep. 2003;52(32):761-4.
  • Dağdelen EÇ, Kılıç Çil M, Çelik T, et al. Theetiology, clinicalcharacteristicsandtreatmentmodalities in childrenwithmeningitisandencephalitis: A retrospectivesinglecenterstudy in Türkiye. J Pediatr Inf. 2023;17(4):234-41. doi:10.5578/ced.20239911.
  • Said S, Kang M. Viral Encephalitis. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Availablefrom: https://www.ncbi.nlm.nih.gov/books/NBK470162/
  • Yamanishi K, Okuno T, Shiraki K, et al. Identification of human herpesvirus-6 as a causalagentforexanthemsubitum. Lancet. 1988;1(8594):1065-7. doi:10.1016/S0140-6736(88)91893-9.
  • Agut H, Bonnafous P, Gautheret-Dejean A. Laboratoryandclinicalaspects of humanherpesvirus 6 infections. ClinMicrobiolRev. 2015;28(2):313-35. doi:10.1128/CMR.00122-14.
  • Rhoads MP, Magaret AS, Zerr DM. Familysalivasharingbehaviorsandage of human herpesvirus-6B infection. J Infect. 2007;54(6):623-6. doi:10.1016/j.jinf.2006.11.006.
  • Saxinger C, Polesky H, Eby N, et al. Antibodyreactivitywith HBLV (HHV-6) in U.S. populations. J VirolMethods. 1988;21(1-4):199-208. doi:10.1016/0166-0934(88)90062-4.
  • Hall CB, Long CE, Schnabel KC, et al. Human herpesvirus-6 infection in children: A prospectivestudy of complicationsandreactivation. N Engl J Med. 1994;331(7):432-8. doi:10.1056/NEJM199408183310703.
  • Suga S, Suzuki K, Ihira M, et al. Clinicalcharacteristics of febrileconvulsionsduringprimary HHV-6 infection. ArchDis Child. 2000;82(1):62-6. doi:10.1136/adc.82.1.62.
  • Abu Sitta E, Khazan A, Luttmann K, et al. HHV-6: an unusualcause of cerebellarataxia. BMJ Case Rep. 2020;13(3):e234303. doi:10.1136/bcr-2020-234303.
  • Crawford JR, Kadom N, Santi MR, et al. Human herpesvirus 6 rhombencephalitisin immunocompetentchildren. J Child Neurol. 2007;22(11):1260-8. doi:10.1177/0883073807307102.
  • Akın F, Yazar A, Türe E, et al. A raredisease: Encephalitisafterexanthemsubitum. Haydarpaşa Numune Med J. 2017;57(2):112-4. doi:10.14744/hnhj.2017.83997.
  • Bartolini L, Theodore WH, Jacobson S, et al. Infectionwith HHV-6 andits role in epilepsy. EpilepsyRes. 2019;153:34-9. doi:10.1016/j.eplepsyres.2019.05.001.

A Rare Condition in Infants: Exanthem Subitum-Induced Encephalitis

Yıl 2025, Sayı: 3, 150 - 154, 14.03.2025
https://doi.org/10.70846/nigdetip.1564248

Öz

Viral encephalitis is inflammation of the brain parenchyma caused by viruses. HHV-6 is one of the causes of this viral infection and is characterized by fever, rash, pharyngitis and generally mild systemic symptoms in infants and children, but it can rarely cause encephalitis. In the present case, a patient with refractory seizures underwent necessary investigations and was diagnosed with HHV-6 encephalitis. In patients presenting with refractory seizures, it should be kept in mind that the seizure may be due to exanthem subitum infection.

Kaynakça

  • Michos AG, Syriopoulou VP, Hadjichristodoulou C, et al. Asepticmeningitis in children: analysis of 506 cases. PLoSOne. 2007;2(7):e674. doi:10.1371/journal.pone.0000674.
  • Martin NG, Iro MA, Sadarangani M, et al. Hospitaladmissionsfor viral meningitis in children in England over fivedecades: a population-basedobservationalstudy. Lancet InfectDis. 2016;16(11):1279-87. doi:10.1016/S1473-3099(16)30201-8.
  • Hviid A, Melbye M. Theepidemiology of viral meningitishospitalization in childhood. Epidemiology. 2007;18(6):695-701. doi:10.1097/ede.0b013e3181567d31.
  • CentersforDisease Control andPrevention (CDC). Outbreaks of asepticmeningitisassociatedwithechoviruses 9 and 30 andpreliminarysurveillancereports on enterovirusactivity—United States, 2003. MMWR Morb Mortal WklyRep. 2003;52(32):761-4.
  • Dağdelen EÇ, Kılıç Çil M, Çelik T, et al. Theetiology, clinicalcharacteristicsandtreatmentmodalities in childrenwithmeningitisandencephalitis: A retrospectivesinglecenterstudy in Türkiye. J Pediatr Inf. 2023;17(4):234-41. doi:10.5578/ced.20239911.
  • Said S, Kang M. Viral Encephalitis. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Availablefrom: https://www.ncbi.nlm.nih.gov/books/NBK470162/
  • Yamanishi K, Okuno T, Shiraki K, et al. Identification of human herpesvirus-6 as a causalagentforexanthemsubitum. Lancet. 1988;1(8594):1065-7. doi:10.1016/S0140-6736(88)91893-9.
  • Agut H, Bonnafous P, Gautheret-Dejean A. Laboratoryandclinicalaspects of humanherpesvirus 6 infections. ClinMicrobiolRev. 2015;28(2):313-35. doi:10.1128/CMR.00122-14.
  • Rhoads MP, Magaret AS, Zerr DM. Familysalivasharingbehaviorsandage of human herpesvirus-6B infection. J Infect. 2007;54(6):623-6. doi:10.1016/j.jinf.2006.11.006.
  • Saxinger C, Polesky H, Eby N, et al. Antibodyreactivitywith HBLV (HHV-6) in U.S. populations. J VirolMethods. 1988;21(1-4):199-208. doi:10.1016/0166-0934(88)90062-4.
  • Hall CB, Long CE, Schnabel KC, et al. Human herpesvirus-6 infection in children: A prospectivestudy of complicationsandreactivation. N Engl J Med. 1994;331(7):432-8. doi:10.1056/NEJM199408183310703.
  • Suga S, Suzuki K, Ihira M, et al. Clinicalcharacteristics of febrileconvulsionsduringprimary HHV-6 infection. ArchDis Child. 2000;82(1):62-6. doi:10.1136/adc.82.1.62.
  • Abu Sitta E, Khazan A, Luttmann K, et al. HHV-6: an unusualcause of cerebellarataxia. BMJ Case Rep. 2020;13(3):e234303. doi:10.1136/bcr-2020-234303.
  • Crawford JR, Kadom N, Santi MR, et al. Human herpesvirus 6 rhombencephalitisin immunocompetentchildren. J Child Neurol. 2007;22(11):1260-8. doi:10.1177/0883073807307102.
  • Akın F, Yazar A, Türe E, et al. A raredisease: Encephalitisafterexanthemsubitum. Haydarpaşa Numune Med J. 2017;57(2):112-4. doi:10.14744/hnhj.2017.83997.
  • Bartolini L, Theodore WH, Jacobson S, et al. Infectionwith HHV-6 andits role in epilepsy. EpilepsyRes. 2019;153:34-9. doi:10.1016/j.eplepsyres.2019.05.001.
Toplam 16 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Çocuk Nörolojisi
Bölüm Olgu Sunumları
Yazarlar

Umut Yorulmaz 0009-0004-7354-2828

Osman Yiğitoğlu 0009-0007-3508-5234

Derviş Barın 0009-0005-3145-8596

Saliha Yavuz Eravcı 0000-0002-5277-5583

Hüseyin Çaksen 0000-0002-8992-4386

Abdullah Akkuş 0000-0002-0642-8759

Yayımlanma Tarihi 14 Mart 2025
Gönderilme Tarihi 14 Ekim 2024
Kabul Tarihi 5 Mart 2025
Yayımlandığı Sayı Yıl 2025 Sayı: 3

Kaynak Göster

Vancouver Yorulmaz U, Yiğitoğlu O, Barın D, Yavuz Eravcı S, Çaksen H, Akkuş A. Süt Çocuğunda Nadir Bir Durum: Eksantem Subitum Kaynaklı Ensefalit. Niğde Tıp Dergisi. 2025(3):150-4.