Tip 2 Diyabetik Vakalarda Ortalama Trombosit Hacmi (MPV) Düzeyleri İle Diyabetik Periferik Nöropati İlişkisi

Year 2019, Volume: 7 Issue: 2, 72 - 76, 27.08.2019

Bülent Bilir , Betül Ekiz Bilir , Neslihan Soysal Atile

Abstract

Amaç: Çalışmamızda Tip 2 diyabetli hastalarda,
MPV değeriyle,
diyabetin mikrovasküler bir komplikasyonu olan nöropati
arasındaki ilişkiyi araştırmayı hedefledik.

Materyal ve Metot:Retrospektif
çalışmamıza, iç hastalıkları polikliniklerimize başvuran tip 2 diyabetik hasta
dosyaları değerlendirilerek, fizik muayene, elektrofizyolojik çalışma verileri,
anamnez ve tetkik kayıtları incelenerek, diyabetik nöropatisi olan ve olmayan
iki grup diyabetik hasta belirlendi. Bilinen kardiyovasküler, hematolojik,
onkolojik hastalık, karaciğer ve böbrek hastalığı, akut veya kronik infeksiyon
hastalığı, yakında geçirilmiş travma, cerrahi öyküsü olan vakalar çalışmaya
dahil edilmedi. Vakaların istatistiksel değerlendirmesi SPSS 21 yazılım
programı ile yapıldı.

Bulgular:Yaşları
31-76 arasında değişen 39'u (25 kadın, 14 erkek) diyabetik periferik
nöropatili, 44’ü (27 kadın, 17 erkek) ise nöropatisiz  toplam 83 diyabetik vaka çalışmaya alındı.
Nöropatisi olmayan vakaların ortalama yaşları 57,89±8,8 (31-75), A1c % 7,3
(5,5-12,7), açlık kan şekeri 144 mg/dl (80-326), trombosit sayısı
260.800±68,900/mm3, MPV değeri 8,96±0,67 fl (7,6-10,4) idi. Nöropatik vakaların
ortalama yaşları 56,54±8,4 (37-76), A1c % 8,3 (5,6-14,4), açlık kan şekeri 184
(100-432) mg/dl, trombosit sayısı 269.050±74.195/mm3, MPV değeri 9,03 ± 0,75
(7,4-10,5) idi. Gruplar arasında yaş (p=0,482), trombosit sayısı (P=0,601), BKİ
(p=0,299), MPV (p=0,596) ve A1c (p=0,076) değerleri açısından anlamlı fark
yokken, diyabet yaşı (p=0,002) ve açlık kan şekeri (p=0,04) açısından
istatistiksel anlamlı fark mevcuttu. Spearman korelasyon analizinde MPV düzeyi
ile nöropati gelişimi arasında istatistiki anlamlılığa ulaşan bir ilişki
bulunamadı (p=0,599). 

Sonuç:
Tip 2 diyabetli 83 hasta ile yaptığımız çalışmamızda, MPV ile nöropati gelişimi
arasında herhangi bir ilişki saptayamadık. Bu ilişkiyi daha iyi aydınlatabilmek
için daha fazla vaka ile çok merkezli ve prospektif çalışmalara ihtiyaç vardır.

Keywords

MPV, Diyabetik nöropati, Tip 2 DM

The relationship between diabetic peripheral neuropathy and MPV (Mean Platelet Volume) values in patients with type 2 diabetes mellitus

Abstract

Objective: We aimed at this study to evaluate the relationship between diabetic peripheral neuropathy which is a microvascular complication of diabetes and MPV values in type 2 diabetes mellitus patients.

Material and Method: We investigated the data of type 2 diabetic patients admitted to our internal medicine out-patient clinics retrospectively. The data was divided as two groups (patients with and without diabetic peripheral neuropathy) according to their history, physical examination, laboratory results and electro-physiological study results. The patients with a known cardiovascular, hematological, oncological, hepatic, renal, acute or chronic infectious disease or a recent history of trauma and surgery were excluded from the study. Statistical analysis was studied by SPSS 21 soft-ware statistics programme.

Results: We included 83 diabetic patients that 39 of them were patients with diabetic neuropathy (25 women, 14 men) and 44 (27 women, 17 men) were without diabetic peripheral neuropathy. Their ages were between 31 and 76. While the means of non-neuropathic group for the age was 57,89±8,8 (31-75), A1c   7,3 % (5,5-12,7), fasting plasma glucose 144 mg/dl (80-326), platelet counts  260.800±68,900/mm³, MPV value 8,96±0,67 fl (7,6-10,4); the means of neuropathic group were 56,54±8,4 (37-76) years, 8,3 (5,6-14,4) %, 269.050±74.195/mm³ and 9,03 ± 0,75 (7,4-10,5) fl respectively. There were no statistically significant differences between two groups in terms of age (p=0,482), platelet count (p=0,601), body mass index (p=0,299), MPV (p=0,596) and A1c (p=0,076). But statistically significant differences were found between groups in terms of diabetes age (p=0,002) and fasting plasma glucose (p=0,04). A statistically significant correlation was not found between MPV value and neuropathy existence by Spearman correlation analysis (p=0,599).

Conclusion: We did not found any correlation between MPV value and neuropathy development in these 83 type 2 diabetic patients in our study. We think that to clarify this relationship certainly, we need a prospective, multi-centered study with a bigger cohort.

Keywords

DM, Diabetic neuropathy, MPV

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